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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

e the predominant therapy class in the pipeline, accounting for 67%. Cytotoxic therapies account for 2% of the pipeline, while immunotherapies account for 15% and gene therapies for 16%.

Colorectal cancer is one of the 'big four' tumor types and has traditionally been a popular R&D target due to its high patient and commercial potential. Following the success of Avastin, drug developers are trying to emulate this, with all three late-phase pipeline products for colorectal cancer targeting angiogenesis.

Pancreatic cancer suffers from high levels of unmet need due to poor prognosis and a resistant nature, resulting in a high rate of Phase III failure. High unmet needs are likely to equate to high commercial reward, which has been noticed by drug developers, making pancreatic cancer the second most popular R&D target after colorectal cancer.

Reasons to Purchase*Identify key drugs and companies within the gastrointestinal cancers pipeline based on sales forecasts to 2019 and Datamonitor drug assessment

*Characterize unmet need and poorly served patient groups within gastrointestinal cancer and assess the potential for pipeline products to fulfill them

*Assess the shifting gastrointestinal cancer market dynamic and how future treatment will incorporate pipeline products

Overview 1

Catalyst 1

Summary 1

ABOUT DATAMONITOR HEALTHCARE 2

About the Oncology pharmaceutical analysis team 2

Executive Summary 3

Strategic scoping and focus 3

Datamonitor insight into the gastrointestinal cancers market 3

Contributing experts 5

Related reports 5

Upcoming related reports 5

TABLE OF CONTENTS 6

1. Pipeline Overview and Dynamics 7

Key findings 7

Pipeline overview 7

Pipeline summary 7

Molecular targeted therapies-either novel agents or marketed products undergoing indication expansion-form the bulk of the current late-ph
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