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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

ver, Abraxane's efficacy in pancreatic cancer arises in part due to its albumin-bound formulation 232

The taxanes are not typically used to treat pancreatic cancer... 232

Abraxis Bioscience's experience in breast cancer will prove useful if Abraxane is approved for pancreatic cancer 233

Satisfaction of unmet needs 233

Forecasts to 2019 233

TNFerade (golnerminogene; GenVec) 234

Drug overview 234

Drug profile 234

Key historical events 235

Clinical trial data 236

Interim data from the PACT study show a 25% reduction in the risk of death when TNFerade is added to standard first-line therapy 237

SWOT analysis 237

Datamonitor drug assessment scorecard for TNFerade 238

Clinical and commercial attractiveness 239

Unmet needs in pancreatic cancer are so high, that if final PACT results are positive, TNFerade will be enthusiastically received 239

No gene therapies are approved for cancer in the seven major markets 240

Intratumoral administration into a pancreatic tumor may prove problematic 240

GenVec may struggle to achieve commercial success for TNFerade without a more experienced oncology player 240

Satisfaction of unmet needs 240

Forecasts to 2019 241

Masitinib (AB-1010; AB Science) 242

Drug overview 242

Drug profile 242

Key historical events 243

Clinical trial data 244

Phase II trial shows a first-line combination of Gemzar and masitinib to confer similar efficacy to Gemzar monotherapy and other Gemzar-based combinations 244

SWOT analysis 245

Datamonitor drug assessment scorecard for masitinib 246

Clinical and commercial attractiveness 247

If Phase II results can be replicated in the ongoing Phase III study, then approval will be likely 247

Masitinib should in theory confer greater efficacy alongside Gemzar than Tarceva due to inhibition of multiple pathways 248


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