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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

Seven major markets 210

Rest of the world 212

Current treatment options 213

Current comparator therapy 215

Gemzar (gemcitabine; Eli Lilly) 215

Unmet need in pancreatic cancer 217

Pancreatic cancer is associated with exceptionally poor survival rates across all stages of disease 217

Earlier rates of diagnosis are desperately needed in order to boost survival 218

A lack of effective systemic therapies exists, therefore a higher level of R&D interest is needed 219

An effective neoadjuvant or adjuvant regimen is required to prevent high rates of recurrence after surgery for early-stage disease 219

More options for the few patients who receive second-line treatment are needed 219

Target product profile versus current level of attainment 220

Pipeline analysis and forecasts 220

Pipeline summary 220

Comparative forecasts 222

Abraxane (albumin-bound paclitaxel; Abraxis Bioscience/Taiho) 224

Drug overview 225

Drug profile 225

Key historical events 226

Clinical trial data 227

Phase II results show Abraxane monotherapy to confer an encouraging median overall survival in the second-line metastatic pancreatic cancer setting 228

Phase I/II results show the addition of Abraxane to first-line Gemzar to boost median overall survival by several months over Gemzar monotherapy 229

SWOT analysis 230

Datamonitor drug assessment scorecard for Abraxane 230

Clinical and commercial attractiveness 231

A combination of encouraging clinical data and key opinion leader enthusiasm mean Abraxane is currently the most promising late-phase pipeline candidate for pancreatic cancer 231

Identification of a potential biomarker could further increase apparent efficacy of Abraxane in pancreatic cancer 232

The widespread availability of generic standard paclitaxel may hamper uptake of Abraxane... 232

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SOURCE Reportlinker
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