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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

ncer metastatic to the liver 196

SWOT analysis 197

Datamonitor drug assessment scorecard for ThermoDox 197

Clinical and commercial attractiveness 198

Phase I results are insufficient to judge ThermoDox's commercial potential 198

Most hepatocellular carcinoma patients present with disease that is too advanced for radiofrequency ablation 199

In order to optimize ThermoDox's commercial potential, Celsion should seek a partner experienced in the oncology market 199

Satisfaction of unmet needs 199

Forecasts to 2019 200

Sutent (sunitinib; Pfizer) 200

Drug overview 200

Drug profile 201

Key historical events 201

Clinical trial data 202

Phase II studies show evidence of some antitumor activity, although toxicity and fatalities associated with Sutent are a concern 203

SWOT analysis 204

Datamonitor drug assessment scorecard for Sutent 205

Clinical and commercial attractiveness 205

Sutent will have to show significantly superior survival benefits in order to effectively compete with

Nexavar in the advanced hepatocellular carcinoma population and overcome negative Phase II results 205

Other late-phase pipeline agents also pose a competitive threat to Sutent 206

Altering Sutent's target patient population in hepatocellular carcinoma could be the key to commercial success 206

Pfizer's growing position in the oncology market will assist in Sutent's potential success 206

Satisfaction of unmet needs 206

Forecasts to 2019 207

7. Pancreatic Cancer 209

Key findings 209

Disease overview 209

Definition 209

Pancreatic cancer represents a major health issue in the developed world 209

Patient segmentation 210

The TNM staging system does not take resectability of a tumor into account, therefore an alternative clinical staging system is often used 210

Epidemiology 210


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