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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

182

Datamonitor drug assessment scorecard for Afinitor 183

Clinical and commercial attractiveness 183

Afinitor's potential is difficult to judge in hepatocellular carcinoma owing to lack of reported data 183

Afinitor is likely to lose out on first-to-market advantage in second-line gastric cancer... 184

...although its mechanism of action could differentiate it from the competition 184

Novartis's experience in the oncology market will prove crucial to ensuring Afinitor's success in hepatocellular carcinoma 184

Satisfaction of unmet needs 184

Forecasts to 2019 185

Linifanib (ABT-869; Abbott) 186

Drug overview 186

Drug profile 186

Key historical events 187

Clinical trial data 188

Phase II results show linifanib to confer clinical benefit in both the first- and second-line treatment settings for advanced hepatocellular carcinoma 188

SWOT analysis 189

Datamonitor drug assessment scorecard for linifanib 190

Clinical and commercial attractiveness 191

By excluding second-line patients from the ongoing Phase III trial, linifanib could show equivalent or superior survival results to Nexavar 191

Other pipeline agents pose a significant threat to linifanib... 192

...therefore Abbott could also target alternative treatment settings or patient subgroups within hepatocellular carcinoma to differentiate linifanib 192

To maximize linifanib's commercial potential, Abbott would be astute in taking on board a marketing partner 192

Satisfaction of unmet needs 192

Forecasts to 2019 193

ThermoDox (liposomal doxorubicin; Celsion/Yakult Honsha) 194

Drug overview 194

Drug profile 194

Key historical events 195

Clinical trial data 196

Phase I results show a favorable overall response rate and low local recurrence rate for ThermoDox and radiofrequency ablation in hepatocellular carcinoma and ca
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