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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

assessment scorecard for brivanib 167

Clinical and commercial attractiveness 168

Competing with Nexavar in the first-line setting may be difficult unless brivanib demonstrates significant superiority... 168

...therefore it is commercially astute of Bristol-Myers Squibb to also target alternative treatment settings 169

Development as an adjuvant to first-line trans-arterial chemo-embolization could also enhance uptake of brivanib 169

Bristol-Myers Squibb is well placed to ensure brivanib's potential in hepatocellular carcinoma is maximized 169

Satisfaction of unmet needs 169

Forecasts to 2019 170

Tarceva (erlotinib; OSI Pharmaceuticals/Genentech/Roche) 171

Drug overview 171

Drug profile 171

Key historical events 172

Clinical trial data 173

Phase II results show Tarceva to confer antitumor activity in advanced hepatocellular carcinoma both as a monotherapy, in combination with chemotherapy and in combination with other molecular targeted therapies 174

SWOT analysis 174

Datamonitor drug assessment scorecard for Tarceva 175

Clinical and commercial attractiveness 176

Tarceva in combination with angiogenesis inhibition has resulted in very encouraging survival results... 176

...therefore Phase III development in combination with Nexavar should in theory result in enhanced efficacy 176

The overall cost of a combination of Nexavar and Tarceva could be prohibitively expensive in some markets 177

Roche's leading position in the oncology market will almost certainly result in success 177

Satisfaction of unmet needs 177

Forecasts to 2019 178

Afinitor (everolimus; Novartis) 179

Drug overview 179

Drug profile 179

Key historical events 180

Clinical trial data 181

Phase I data suggest that Afinitor is capable of stabilizing progression of hepatocellular carcinoma 182

SWOT analysis
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