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Pipeline Insight: Gastrointestinal Cancer Overview - Metastatic Gastrointestinal Cancers Represent a Significant Commercial Opportunity Due to a Lack of Approved Drugs
Date:11/4/2010

>Clinical trial data 143

Only Phase I results in solid tumors have been made available to date 143

SWOT analysis 144

Datamonitor drug assessment scorecard for ramucirumab 144

Clinical and commercial attractiveness 145

A lack of clinical trial data makes it difficult to judge ramucirumab's potential in gastric cancer 145

Ramucirumab will lose out to Afinitor in terms of first-to-market advantage for second-line gastric cancer 145

The failure of Avastin in the first-line setting may work in ramucirumab's favor 146

Eli Lilly's experience in the oncology market will prove crucial in ensuring ramucirumab's success in gastric cancer 146

Satisfaction of unmet needs 146

Forecasts to 2019 147

6. Hepatocellular Carcinoma 149

Key findings 149

Disease overview 149

Definition 149

Hepatitis is a known risk factor for hepatocellular carcinoma 149

Patient segmentation 150

Several staging systems exist for hepatocellular carcinoma 150

Epidemiology 151

Seven major markets 151

Rest of the world 152

Current treatment options 153

Current comparator therapy 155

Nexavar (sorafenib; Onyx Pharmaceuticals/Bayer Schering) 155

Unmet need in hepatocellular carcinoma 155

Better systemic therapy is required in all lines of treatment 156

Clinical trials are currently poorly designed 157

Target product profile versus current level of attainment 157

Pipeline analysis and forecasts 158

Pipeline summary 158

Comparative forecasts 160

Brivanib (BMS-582664; Bristol-Myers Squibb) 163

Drug overview 163

Drug profile 163

Key historical events 164

Clinical trial data 165

Phase II results show brivanib to confer activity in both the first- and second-line treatment settings for advanced hepatocellular carcinoma 165

SWOT analysis 166

Datamonitor drug
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