Navigation Links
Pinnacle Oncology LLC Acquires Rights to Unique Radioprotector From the University of Chicago

BANNOCKBURN, Ill., June 27, 2011 /PRNewswire/ -- Pinnacle Oncology LLC, a subsidiary of Pinnacle Biologics Inc. announced a wide ranging agreement with the University of Chicago for the acquisition of its technology and intellectual property rights for the development of a compound, amifostine, to prevent genomic instability caused by a variety of sources of ionizing radiation exposure including common Computer Tomography (CT) scans.

Amifostine was initially developed by the United States Army to protect military personnel from the toxic effects of radiation exposure in the event of a nuclear war.  Animal studies revealed that amifostine is very effective in protecting against genomic instability and associated long term genomic damages resulting from radiation exposure, such as from CT scans and other diagnostic radiology and radiation oncology procedures that lead to DNA damages, chromosomal aberrations and gene mutations, all of which are associated with the cancer development processes.

"There are many potential uses for amifostine," said David Grdina, Professor of Radiation and Cellular Oncology at the University of Chicago and inventor of the technology behind the development of amifostine as a genomic stabilizing agent, "In addition to protecting against genomic instability, somatic mutagenesis and carcinogenesis, amifostine may also facilitate protection against germ line mutations. These exposures can come from a variety of sources including common diagnostic procedures, such as computer tomography (CT) scans and more generalized environmental exposures, as recently evidenced by the nuclear plant accident in Japan."  At present, none of these potential uses have been approved by the FDA.

According to Viren Grover, Vice-Chairman at Pinnacle Biologics, "It is clear that CT scans have revolutionized diagnostic imaging and while they can provide great medical benefits, there is concern that diagnostic CT scans may be responsible for elevating genomic instability processes.  Over 70 million CT scans were performed in the U.S. alone in 2007.  A study led by National Institute of Cancer suggested that this may contribute to 29,000 new cancers each year along with 14,500 deaths.  Our proposal is to develop amifostine for the prevention of genomic instability in high risk individuals undergoing CT diagnostic procedures."

About Pinnacle Biologics, Inc.

Pinnacle Biologics, a privately held bio-pharmaceutical company, specializes in revitalizing healthcare therapies to fulfill their true potential and to maximize favorable patient outcomes. This is accomplished through licensing and acquisition of specialty pharmaceuticals and medical devices. Our innovative approach to opportunity analysis, business development, lifecycle management, regulatory expertise and distribution leverage takes each product to its highest degree of potential and maximum patient benefit.

About University of Chicago

The University of Chicago is a private, nondenominational, culturally rich and ethnically diverse coeducational institution of higher learning and research. The University enrolls approximately 15,500 students overall and in 2010 received $472 million in sponsored research funding. Since 1892, UChicago scholars, scientists and educators have made a profound and lasting impact upon the world. The University's Office of Technology and Intellectual Property, UChicagoTech, manages the University's dissemination of intellectual property through commercial channels, including inventions, software, and educational or research materials involving new information technology.

Contact Information:

Viren Grover
Pinnacle Biologics, Inc.
2801 Lakeside Dr - Suite 209
Bannockburn, IL 60015
P: 1.847.283.7690
F: 1.847.283.7695

SOURCE Pinnacle Biologics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
2. HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership
3. Genasense(R) Data in Melanoma to be Presented in Opening Session at First Worldwide Melanoma Center Meeting of the European Association of Dermato-Oncology
4. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
5. Strategic Diagnostics Launches Initial Oncology-Targeted Antibody Reagent Catalog
6. University of Pennsylvania School of Medicine Study Shows Significant Differences in English- and Spanish-speakers Use of Oncology Websites
7. Statement by US Oncology on FDA Label on Erythropoiesis Stimulating Agents (ESAs)
8. Pharsight Uses FDA Disease Model to Support Oncology Drug Development
9. US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium
10. IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology
11. Preliminary PI-88 Phase 2 Prostate Cancer Results to be Presented at the American Society for Clinical Oncology (ASCO) 2008 Genitourinary Cancer Symposium
Post Your Comments:
(Date:10/13/2015)... , October 14, 2015 ... The Global Nocturia Clinical Trials Review, H2, ... of worldwide Nocturia scenario, top line data ... as information on companies and institutes involved. ... . --> ...
(Date:10/13/2015)... NEW YORK , Oct. 13, 2015 ... been filed against Amicus Therapeutics, Inc. ("Amicus" or the ... action, filed in United States District Court, District of ... of a class consisting of all persons or entities ... October 1, 2015 inclusive (the "Class Period"). This class action ...
(Date:10/13/2015)... 13, 2015  The Alliance for Safe Biologic ... survey of 401 U.S. pharmacists showing strong support for ... for more transparency in labeling. Michael Reilly ... "This survey reinforces what ASBM has been hearing ... it clear that they prefer distinguishable names and more ...
Breaking Medicine Technology:
(Date:10/13/2015)... , ... October 13, 2015 , ... ... celebrating the opening of the Integrative Biosciences Center (IBio), a $93 million facility ... A grand opening celebration will be held at 10:30 a.m. Wednesday, Oct. 14, ...
(Date:10/13/2015)... ... October 14, 2015 , ... The ... of needle-placement technique in radiofrequency ablation for treatment of lumbar facet arthropathy ”. ... in nature, highlights the importance of anatomically correct needle placement technique for lumbar ...
(Date:10/13/2015)... ... October 13, 2015 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... A Commitment to Cure last night at the Mandarin Oriental in New York ...
(Date:10/13/2015)... ... 13, 2015 , ... “Women have 2 questions when they find out they ... second is, “Will I lose my hair?’” , Carly Klein is the Founder of ... medical professionals to develop personalized hair loss treatment plans. With 10 years’ experience in ...
(Date:10/13/2015)... ... October 13, 2015 , ... Though trick-or-treating remains ... confines of their home. Whether it's making fun pre or post trick-or-treat snacks ... Florida Dairy Farmers. , Recipe 1: Green Chile Queso Dip with Sriacha ...
Breaking Medicine News(10 mins):