Pilot Study Opens the Door for Avastin Use in Curative Setting for Women With Bre... (one of two treatment arms: -- Treat...)

HOME >> MEDICINE >> TECHNOLOGY

Pilot Study Opens the Door for Avastin Use in Curative Setting for Women With Breast Cancer

Date:12/17/2007

one of two treatment arms:

-- Treatment arm A received dose-dense combination of doxorubicin and

cyclophosphamide with Avastin, followed by paclitaxel and Avastin,

followed by Avastin alone. Avastin was given every 2 weeks at a dose

of 10 mg/kg for 1 year.

-- Treatment arm B was only different to arm A in that Avastin was

introduced after completion of doxorubicin therapy in conjunction with

paclitaxel. As with arm A, patients remained on Avastin for 1 year

after Avastin initiation.

The primary objective of the study was to determine the incidence of clinically apparent cardiac dysfunction in patients with lymph node positive breast cancer treated with bevacizumab and dose dense doxorubicin/cyclophosphamide followed by paclitaxel (ddAC>T). Patients were evaluated clinically and with serial assessments of left ventricular function over the course of their treatment and for six months following treatment.

Additional information

-- Roche in Oncology:

http://www.roche.com/pages/downloads/company/pdf/mboncology05e_b.pdf

-- Roche Health Kiosk, Cancer:

http://www.health-kiosk.ch/start_krebs

References:

(1) Miller KD, et al. E2100 Breast Cancer Res Treat 2005;94:S6

(Abstract 3)

(2) Kamangar F, et al. J Clin Oncol 2006; 24(14): 2137-50.

0

GOOD

Page: 1 2 3
Related medicine technology :

1. Preliminary Results of Randomized Pilot Study Show Comparable Efficacy for OrbusNeichs Genous(TM) Bio-engineered R Stent(TM) and Boston Scientifics Taxus(R) Stent in Patients at High Risk of Restenosis
2. PLC Systems Achieves Successful Early Conclusion of RenalGuard(TM) Pilot Safety Trial
3. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
4. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
5. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
6. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
7. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
10. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
11. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression

Post Your Comments:

Pilot Study Opens the Door for Avastin Use in Curative Setting for Women With Bre...(one of two treatment arms: -- Treat...),Health