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Pilot Study Opens the Door for Avastin Use in Curative Setting for Women With Breast Cancer
Date:12/17/2007

one of two treatment arms:

-- Treatment arm A received dose-dense combination of doxorubicin and

cyclophosphamide with Avastin, followed by paclitaxel and Avastin,

followed by Avastin alone. Avastin was given every 2 weeks at a dose

of 10 mg/kg for 1 year.

-- Treatment arm B was only different to arm A in that Avastin was

introduced after completion of doxorubicin therapy in conjunction with

paclitaxel. As with arm A, patients remained on Avastin for 1 year

after Avastin initiation.

The primary objective of the study was to determine the incidence of clinically apparent cardiac dysfunction in patients with lymph node positive breast cancer treated with bevacizumab and dose dense doxorubicin/cyclophosphamide followed by paclitaxel (ddAC>T). Patients were evaluated clinically and with serial assessments of left ventricular function over the course of their treatment and for six months following treatment.

Additional information

-- Roche in Oncology:

http://www.roche.com/pages/downloads/company/pdf/mboncology05e_b.pdf

-- Roche Health Kiosk, Cancer:

http://www.health-kiosk.ch/start_krebs

References:

(1) Miller KD, et al. E2100 Breast Cancer Res Treat 2005;94:S6

(Abstract 3)

(2) Kamangar F, et al. J Clin Oncol 2006; 24(14): 2137-50.


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SOURCE Roche
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