Navigation Links
Phytomedics Inc. Announces Publication of the Phase 2b Clinical Trial Results of an Extract of the Chinese Herbal Remedy Tripterygium wilfordii Hook F in Rheumatoid Arthritis
Date:8/19/2009

d study was conducted at 11 sites in the U.S., under the auspices of the National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Patients received the TwHF extract 180 mg/day, divided TID (n=60) or SSZ 2 g once daily (n=61) for 24 weeks. The primary endpoint of the study was a 20% improvement in disease activity by ACR criteria (ACR20).

At six months 67.6% of PMI-001-treated patients vs. 36.0% of SSZ-treated patients achieved at least a 20% improvement in disease activity (p=0.02). In the TwHF group, ACR 50 and ACR 70 responses were observed in 54.1% and 37.8% of patients. In the SSZ group, both ACR50 and ACR70 responses were 4.0% (p<0.001 for all comparisons). Significant improvement was seen with all endpoints as early as 2 weeks, including physical function as measured by the HAQ disability score. Patients receiving TwHF had no progression of mean joint space narrowing and erosion scores.

The most common adverse events in both treatment arms were gastrointestinal tract disturbances. Serious adverse events occurred in 3 patients on PMI001 and 7 patients on SSZ. Discontinuations for AEs occurred in 8 (13%) PMI001 patients and 17 (28%) SSZ patients.

Despite recent therapeutic advances, there remains significant unmet medical need for novel alternative therapies for many patients with rheumatoid arthritis. Many of these patients, even after treatment with multiple oral and parenteral drugs, continue to experience uncontrolled pain, joint swelling, fatigue, and impaired physical function. Dr. Laurie Smaldone, President and CEO of Phytomedics Inc. added "We are very pleased with the outcome from this study. We look forward to meeting with FDA to discuss development plans for PMI-001."

About PMI-001

PMI-001 is a novel, oral, disease modifying anti-rheumatic drug currently being developed as a natura
'/>"/>

SOURCE Phytomedics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
5. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
6. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
7. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
8. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
9. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
10. Genta Incorporated Announces Second Quarter 2007 Financial Results and Corporate Highlights
11. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... , March 31, 2015  The efficacy of continuous ... in a recently published study 1 of ultraviolet ... research team, including Curtis Donskey , M.D.  The ... for the same length of time from the same ... unit.  The results showed surprisingly low pathogen kill rates ...
(Date:3/31/2015)... According to a new ... Market (Chromatography, Electrophoresis, DNA Sequencer, PCR, Microplate Reader, Robotics, ... Centrifuge) - Global Forecast to 2019", published by ... Market is expected to reach $48.84 Billion by ... 2019. Browse   9 ...
(Date:3/31/2015)... Calif. , March 31, 2015  Frequentz Inc., ... has released a white paper to help the pharmaceutical ... 2013 Drug Supply Chain Security Act (DSCSA). The white ... stages of the GS1 EPCIS Standard(s) and ... outlook on the product tracing requirements that need to ...
Breaking Medicine Technology:VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 2VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 3VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 4Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 2Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 3Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 4Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 5Frequentz Releases White Paper Addressing DSCSA's Current & Future Impact 2Frequentz Releases White Paper Addressing DSCSA's Current & Future Impact 3
... Causing Mitochondrial Disease More Common Than Previously,Believed, ... (UMDF) today announced landmark research finding that,one in ... could potentially cause a,mitochondrial disease in them or ... fatal disease, and mitochondrial disorders are at,the core ...
... Sanofi-aventis,(EURONEXT: SAN and NYSE: SNY) announced today ... priority review status for its New Drug,Application (NDA) ... July 31, 2008., The priority review is ... new drug product, if approved, has the potential ...
Cached Medicine Technology:New Research Shows One in 200 People Born with DNA Mutation That Can Lead to Devastating, Often Fatal Disease 2New Research Shows One in 200 People Born with DNA Mutation That Can Lead to Devastating, Often Fatal Disease 3Multaq(R) (dronedarone) Granted FDA Priority Review for Patients with Atrial Fibrillation 2Multaq(R) (dronedarone) Granted FDA Priority Review for Patients with Atrial Fibrillation 3
(Date:3/31/2015)... 2015 Healthpointe’s team of hip ... of their clinics. Specialties include hip dislocations, fractures, bursitis, ... athletes with hip injuries, Healthpointe has a renowned team ... the symptoms and underlying causes of the hip pain. ... prevent future damage, while taking into consideration the patient’s ...
(Date:3/31/2015)... 2015 Former 49ers linebacker Chris Borland turned ... first year of a promising NFL career. In a March ... Senior Writer Will Leitch explores the curious case of ... about the decision making process that Borland and other football ... over a large paycheck, and what impact, if any, he ...
(Date:3/31/2015)... March 31, 2015 Array Health ... technology, has announced that Lance Hood, Senior Director of ... Private Exchange Forum on April 1, 2015. The session, ... Benaissance, will address how employers can streamline and simplify ... , WHAT: “ Optimizing Employee and Employer Needs in ...
(Date:3/31/2015)... March 31, 2015 As the scientific ... Energy Balance Network (GEBN) is poised to make ... public health. GEBN is a network of scientists ... Africa, Asia and Oceania who have banded together to ... by the body (energy balance) and apply this understanding ...
(Date:3/31/2015)... York (PRWEB) March 31, 2015 Lipitor ... individuals who allegedly developed new-onset Type 2 diabetes due ... move forward in the federal multidistrict litigation now underway ... to an Order issued on March 26th, jury selection ... November 4, 2015. (In re Lipitor (Atorvastatin) Litigation, MDL ...
Breaking Medicine News(10 mins):Health News:Healthpointe Now Treating Hip Dislocations, Hip Fractures, Hip Bursitis, and Hip Strains at Locations in Southern California 2Health News:Will Leitch and the Curious Case of Chris Borland on SCI TV 2Health News:Will Leitch and the Curious Case of Chris Borland on SCI TV 3Health News:Array Health’s Senior Director of Marketing to Co-Present with Benaissance at The Institute for HealthCare Consumerism Private Exchange Forum 2Health News:Global Energy Balance Network Experts from Six Continents Join Forces to Reduce Obesity, Including the University of Colorado Anschutz Health and Wellness Center's James O. Hill, PhD 2Health News:Global Energy Balance Network Experts from Six Continents Join Forces to Reduce Obesity, Including the University of Colorado Anschutz Health and Wellness Center's James O. Hill, PhD 3Health News:Lipitor Lawsuit News: Jury Selection for First Federal Bellwether Trial to Commence November 4th 2Health News:Lipitor Lawsuit News: Jury Selection for First Federal Bellwether Trial to Commence November 4th 3
... July 31 Nevique(TM), a newly,founded skin care ... revolutionary new Omega 3 skin care technology at ... TX on August 5-8, 2008. The,Nevique(TM) skin care ... balm formulas: 1) Ultra Moisturizer, 2) Daily Conditioner, ...
... Cyberonics, Inc. (Nasdaq:,CYBX) today announced that the company will report ... its fiscal year ending April 24,2009 on Thursday, August 21, ... call to discuss those results on the same day at ... Conference Call Instructions, To listen to the conference call ...
... cells to treat fatal disease, researchers say , , THURSDAY, July ... patients with Lou Gehrig,s disease into motor neurons that are ... number of these neurons can now be created and studied ... better understanding of the disease and, one day, lead to ...
... , ... Orlando, FL (Vocus) July 31, 2008 -- ... in its "Hype Cycle for Healthcare Payers, 2008" report. Connextions, a ... retain and manage individual and small group members. , ...
... Announced, ROCHESTER, Mich., July 31 Oakland,University,s ... Robert,Folberg, M.D., as the founding dean of the ... in 2010 with a charter class of,50 students. ... of the,school -- Oakland University William Beaumont School ...
... president & chief operating officer, Medco Health Solutions, Inc.,(NYSE: ... Capital Markets 2008 Focus on,Healthcare Conference in New York ... the Millennium Broadway Hotel will begin at 9:00,a.m. ET. ... to,attend., The presentation may be heard live via ...
Cached Medicine News:Health News:Nevique Skin Care Company Introducing the Revolutionary New Omega 3 Skin Care Technology 2Health News:Cyberonics Announces Conference Call to Discuss Fiscal Year 2009 First Quarter Financial Results 2Health News:Scientists Turn Skin Cells Into Motor Neurons in ALS Patients 2Health News:Scientists Turn Skin Cells Into Motor Neurons in ALS Patients 3Health News:Connextions Cited in Leading Industry Analyst Firm's "Hype Cycle" For Health Care Provider Marketing Applications 2Health News:Connextions Cited in Leading Industry Analyst Firm's "Hype Cycle" For Health Care Provider Marketing Applications 3Health News:OU, Beaumont Name Dean of New Medical School 2Health News:OU, Beaumont Name Dean of New Medical School 3Health News:Medco to Present at the BMO Capital Markets 2008 Focus on Healthcare Conference 2
... designed to optimize the accuracy and precision ... products is widely recognized by customers throughout ... extended over the years and now covers ... tips including filter tips, certified pure tips, ...
... Processor is a primary component of an ... processing, sampling, and slide preparation all ... MonoPrep LBP Processor produces high-quality sample slides ... range of cytology specimen types. It processes ...
... innovative, quick and easy automated refill ... less space on your laboratory bench ... amazingly easy-to-use, one-hand system, you only ... range of Diamond Tips. All sizes ...
200 L, Racked, Pre-sterilized, 96 tips/rack, clear Recommended for 20, 25, 50, 100 and 200 L pipettes. Can also be used with 300 L pipettes when pipetting 200 L or less....
Medicine Products: