Navigation Links
Phico Therapeutics Receives GBP1 Million Award From the Wellcome Trust to Take Anti-MRSA Nasal Product Through Early Clinical Trials

CAMBRIDGE, England, January 28 /PRNewswire/ -- Phico Therapeutics today announced it has been granted a Wellcome Trust Strategic Translational Award totalling GBP1.03 million to cover Phase I and II trials of its lead candidate SASPject(TM) PT1.2 for nasal decolonisation of MRSA and S. aureus. PT1.2 is based on a new class of antibacterial proteins called SASPs which bind to bacterial DNA resulting in rapid "speed of kill". Phico envisages developing a fast-acting, easily applicable nasal gel which would combat both hospital S. aureus infection and hospital and community MRSA transmission and drug-resistance.

According to Phico Therapeutics CEO and founder, Dr Heather Fairhead, there is a clear need for such a product. "Whilst hospitals have introduced stricter cleaning regimes, the twin problems of transmission and drug-resistance remain. We already demonstrated last year in several studies, including some carried out in conjunction with the UK's Health Protection Agency, that PT1.2 is rapidly bactericidal against more than 200 clinical S. aureus and MRSA isolates, spanning the known MRSA types in Europe and the US. Indeed in the speed of kill assay, SASP caused a greater than or equal to 99.9 % drop in viability within 2 minutes against a 10(5) culture and a greater than or equal to 99.9 % drop in viability within 10 minutes against a 10(7) culture of a major US MRSA strain. I am delighted that the Wellcome Trust see the potential of PT1.2. This award will enable us to conduct phase I and II clinical trials with results expected Q3 2009 and Q3 2010 respectively."

Dr Ted Bianco, Director of Technology Transfer at the Wellcome Trust commented: "There is an urgent need to develop innovative ways to manage the transmission of antibiotic-resistant bacteria in the hospital and care-home environments. The approach being taken by Dr Fairhead and colleagues is imaginative and original. If successful, this technology may provide an important new tool in the fight against MRSA and other pathogenic bacteria."

Dr Fairhead also added that other SASP candidates in the Company's pipeline are being developed against C. difficile and E. coli/Klebsiella pneumoniae, and a modified PT1.2 is being developed for intravenous use and that she would be seeking further funding to advance their development.

    Corporate Enquiries
    Heather Fairhead
    Tel: +44(0)1223-496562

SOURCE Phico Therapeutics
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
2. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
3. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
4. TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
5. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
6. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
7. Protalix BioTherapeutics Treats First Patient in Phase III Clinical Trial of prGCD
8. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
9. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
10. Cell Therapeutics, Inc. (CTI) Launches Phase III Study for Pixantrone in Relapsed Indolent Non-Hodgkins Lymphoma (NHL)
11. Cell Therapeutics, Inc. (CTI) Sponsors Panel Discussion on Women and Lung Cancer on Capitol Hill
Post Your Comments:
(Date:11/26/2015)... , November 26, 2015 ... addition of the "2016 Future Horizons ... of Abuse Testing Market: Supplier Shares, Country ... report to their offering. --> ... the "2016 Future Horizons and Growth ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Drug Monitoring (TDM) Market: Supplier Shares, ... Opportunities"  report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Italian therapeutic drug monitoring market, including emerging ...
Breaking Medicine Technology:
(Date:11/26/2015)... ... 2015 , ... The Catalent Applied Drug Delivery Institute today ... dose form selection in early phase drug development. The first of these is ... together the UK’s emerging life sciences companies, corporate partners, and investors, at Milton ...
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is updating ... our surgeons performed their 6,000th free flap breast reconstruction surgery! , “What an accomplishment ... day excited to rebuild lives and it’s an honor to have served all of ...
(Date:11/26/2015)... ... 26, 2015 , ... Pixel Film Studios brings Final Cut ... Vintage. This newly styled ProTrailer pack comes with 30 all-new vintage-inspired designs, with ... users limitless opportunities to stylize and create designs quickly and easily, all within ...
(Date:11/26/2015)... , ... November 26, 2015 , ... Indosoft Inc., developer ... of an application server to improve system efficiency and reliability. , The new Q-Suite ... of these standards, the system avoids locking itself into a specific piece of software ...
(Date:11/25/2015)... ... November 25, 2015 , ... As part of a global ... attracts volunteers together who want to combine talents and resources to help create ... the process. The non-profit launched its first major fundraiser on November 6, 2015 ...
Breaking Medicine News(10 mins):