Navigation Links
Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis
Date:3/23/2009

ral neck and total hip BMD, serum bone turnover markers, mammographic breast density and safety.(1) The study included postmenopausal women with osteoporosis with a mean age of 63 years and a mean lumbar spine BMD T-score of -2.9.

12-month results included:(1)

  • Arzoxifene significantly increased BMD at all sites to a greater extent than raloxifene, respectively (p<0.05 for all comparisons):
    • Lumbar spine BMD (2.8 percent vs. 1.7 percent)
    • Femoral neck BMD (1.5 percent vs. 0.5 percent)
    • Total hip BMD (1.5 percent vs. 0.8 percent)
    • For lumbar spine and femoral neck, this effect was statistically significant as early as six months.
  • Arzoxifene significantly suppressed bone turnover to a greater extent than raloxifene, respectively (p<0.05 for all comparisons):
    • CTX (biochemical marker of bone resorption); -40.6 percent vs. -29.8 percent
    • PINP (biochemical marker of bone formation) : -41.5 percent vs. -30.8 percent
    • Arzoxifene suppressed bone turnover to a greater extent than raloxifene as early as three months.
  • New or worsening hot flushes were reported less frequently with arzoxifene versus raloxifene (7.0 percent vs. 16.7 percent; p=0.009).
  • There were not any between-group or within-group differences in change of percentage of breast density.
  • The proportion of women reporting one or more adverse events, including vaginal bleeding, did not differ between treatment groups.
  • No cases of endometrial polyps, hyperplasia or cancer were reported.
  • Nasopharyngitis and bronchitis were reported more frequently with arzoxifene versus raloxifene (10.1 percent vs. 2.5 percent, and 5.1 percent vs. 0 percent, respectively; p less than or equal to 0.
    '/>"/>

SOURCE Eli Lilly and Company
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients
2. Innocoll Announces Dosing of Last Patient in Second US Phase 3 Clinical Trial to Investigate GENTAMICIN SURGICAL IMPLANT for Prevention of Surgical Site Infections in Colorectal Surgery Patients
3. Cephalon Announces Positive Results From a Phase Two Study of NUVIGIL in Bipolar Depression
4. Walter Reed Army Medical Center offers HIFU for Qualifying Men with Locally Recurrent Prostate Cancer in a Phase III Clinical Trial
5. Healthpoint Initiates Phase II, Dose-Finding Study to Evaluate Effectiveness of a Unique Cell Based Therapy in Venous Leg Ulcers
6. DURECT Reports Positive Phase IIb Data from TRANSDU(TM)-Sufentanil Clinical Program
7. Innocoll Announces Dosing of Last Patient in US Phase 3 Clinical Trial to Investigate GENTAMICIN SURGICAL IMPLANT for Prevention of Surgical Site Infections in Cardiac Surgery Patients
8. Video: Provectus PV-10 Interim Phase 2 Safety and Efficacy Results are as Good as or Better than Phase 1 Results
9. Nobilon Advances First Vaccine Into Human Trials - Intranasal Influenza Vaccine Begins Phase I Clinical Development
10. Rigel Commences Phase 2 Trial of R788 in Peripheral T-Cell Lymphomas
11. Oncolytics Biotech(R) Inc. Announces Start of Enrolment in U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 2015 More than 1,500 substance abuse prevention ... in Indianapolis Aug. 2-6 for ... Training Institute . The week-long training, held at the ... of our nation,s biggest public health challenges – youth ... is a one-of-a-kind intensive training opportunity, offering more than ...
(Date:7/31/2015)... , July 31, 2015  Boston Children,s ... benefiting from 3D printing of their anatomy before ... life-threatening cerebrovascular malformations (abnormalities in the brain,s blood ... Reporting online today in the Journal of ... of 3D printing and synthetic resins to create ...
(Date:7/31/2015)... 2015 Egalet Corporation (Nasdaq: EGLT ... focused on developing, manufacturing and marketing innovative pain ... announced underwritten public offering of 7,666,667 shares of ... of $11.25 per share. The shares of common ... upon the exercise in full by the underwriters ...
Breaking Medicine Technology:Community Leaders From Across The Country Head To Indianapolis For CADCA 2015 Mid-Year Training Institute Aug. 2-6 23D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4
(Date:8/1/2015)... ... August 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director ... Appalachian Trail by stepping off Springer Mountain and heading north. Since that day, ... Phil reached Connecticut and was greeted by friends and family. He visited CCAR and ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot and ... new type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for ... commemorate introduction of this new type of sod, Super-Sod is giving away red Adirondack ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Ticket Down ... is currently going on in Chicago at Grant Park. The festival will end ... of North America to Chicago for the annual Lollapalooza. This unique and unbelievably ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... run by GoodThreads. The store can be accessed by visiting http://www.curemeso.org/store . ... which are customizable. The best part: whenever a product is purchased, the Meso ...
(Date:7/31/2015)... , ... July 31, 2015 , ... There’s no better ... even when it comes time to cook the next meal, making July the most ... by practicing best grilling tips and recipes. , Make the next cookout different than ...
Breaking Medicine News(10 mins):Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3
... parents’ when compared to rugby-codes. But this opinion stands challenged, ... for the highest injuries as compared to all other types ... topped the charts of contact sports injuries, the second place ... and the last , being soccer. ,A report published ...
... suspected to have contacted meningococcal disease are being treated at ... who hail from Cobar and Mudgee respectively, are showing signs ... possible to relate both the cases, based on the evidence ... Western Area Health Service. In addition, family members and friends ...
... SOS has found that firms are concentrating on "tracking ... than stockpiling protective equipment like gloves and masks in ... // ,The survey found that only 36 of ... steps, "Organizations with distributed, global workforces want to be ...
... expression pattern of certain microRNA’s heve been found that ... ,The analysis of these findings indicates that miRNAs may ... for lung cancer. ,The Ohio State University ... of Medicine, Tokyo, Japan; National Cancer Centre Research Institute, ...
... LONDON - A drug trial in northwest London went horribly ... trial are now battling for life at the emergency ward ... in the trial of a drug to treat conditions such ... volunteers were given a placebo and were healthy, but the ...
... frozen embryos are stored in Britain. They are living balls of ... their lives to begin again. // , Lois Walker ... was born in April 2000. Her gestation period lasted for more ... been an eight-celled embryo and spent about 30 months in a ...
Cached Medicine News:Health News:Lung cancer molecular profile discovered by researchers. 2Health News:Frozen embryos stored in Britain 2
The ImagingPlanet 55 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Zeiss surgical micro...
... Capture Archive Manage ... Images. ,Introducing Optronics DVMR- office, ... system designed for the physician's ... from a variety of high-resolution ...
... Optronics QuantiFIRE represents the latest innovation ... scientific grade CCD imaging for microscopy. ... Monochrome CCD camera developed exclusively for ... fluoresence or NIR imaging applications where ...
... This system is the most ... world. Developed in the USA after ... safety, and complete precision with maximum ... exfoliation. It is superior to traditional ...
Medicine Products: