Navigation Links
Phase III Study of Abbott's Investigational TriLipix(TM) in Combination With AstraZeneca's CRESTOR(R) Meets Primary Endpoints on Key Lipids
Date:5/31/2008

Data Show TriLipix (ABT-335) in Combination with CRESTOR (rosuvastatin

calcium) Improved LDL, HDL and Triglycerides and Had Reported Safety

Consistent with Monotherapies

SEATTLE, May 31 /PRNewswire-FirstCall/ -- New Phase III data showed that in patients with multiple lipid problems, Abbott's investigational TriLipix(TM) (ABT-335) combined with AstraZeneca's CRESTOR(R) (rosuvastatin calcium) led to greater improvements than the corresponding monotherapy in treating all three key lipids -- LDL "bad" cholesterol, HDL "good" cholesterol and triglycerides. Results from this Phase III study were presented today at the National Lipid Association's 2008 Scientific Sessions in Seattle.

This study of more than 1,400 patients is part of the largest clinical program to date designed to evaluate the efficacy and safety of a fibrate in combination with statins. Data from the study showed that TriLipix in combination with rosuvastatin met its primary endpoints with significantly greater improvements in HDL and triglycerides compared to rosuvastatin alone, and significantly greater improvements in LDL compared to TriLipix alone. Both the combinations and rosuvastatin alone resulted in clinically meaningful reductions in LDL. In the clinical trial, TriLipix in combination with rosuvastatin was generally well tolerated, with reported safety similar to the monotherapies. No rhabdomyolysis (a rare muscle disorder) or unexpected liver, kidney or muscle safety issues were identified in this study.

"Patients with mixed dyslipidemia may need treatment options that help address these three key lipids," said Peter H. Jones, M.D., FACP, Methodist DeBakey Heart and Vascular Center, Houston, and a lead investigator of the trial. "Results from this study showed that TriLipix in combination with rosuvastatin significantly increased HDL, and decreased both LDL and triglycerides."

According to the American Heart Association (AHA), mo
'/>"/>

SOURCE Abbott
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 2014  eRelevance Corporation ( www.erelevancecorp.com ), a ... it has completed integration with Nextech, a popular ... and Dermatology practices. "Integration allows our ... practices using Nextech," stated Bob Fabbio , ... from the EMR we are able to automatically ...
(Date:8/21/2014)... - Eisai Limited is pleased to support the Canadian Epilepsy ... available in Canada . The comic book, ... children and their parents about epilepsy, the most common neurological ... 300,000 Canadians. Eisai is guided by a corporate philosophy known ... patient is central – there was a need within the ...
(Date:8/21/2014)... Aug. 21, 2014 /PRNewswire-iReach/ -- Inc. ... for the third straight year, No. 349 in ... exclusive ranking of the nation,s fastest-growing private companies. ... the most important segment of the economy—America,s independent ... Domino,s Pizza, LinkedIn, Zillow, and many other well-known ...
Breaking Medicine Technology:eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3
... Corporation (NYSE: POL ), a premier global ... showcase a growing range of specialty healthcare solutions at ... With more than 200 participating companies and 6,000 ... medical device manufacturing sector in China.   ...
... Sept. 6, 2011 Isis Pharmaceuticals, Inc. (Nasdaq: ... Open-Label Extension Study presented at ESCWhen: , Wednesday, September 07, ... www.isispharm.comHow: , Live on the Internet.  Simply log onto our ... during the live event, a replay of the webcast will ...
Cached Medicine Technology:PolyOne's Healthcare Solutions and Distribution Network Showcased at Medtec China 2PolyOne's Healthcare Solutions and Distribution Network Showcased at Medtec China 3
(Date:8/23/2014)... 2014 "When men sit down to ... with the dirty water inside the bowl, the interior ... one of two inventors from Naugatuck, and Bridgeport, Conn. ... this protective device." , They developed the IPSAFE to ... the water, bowl and seat. This minimizes exposure to ...
(Date:8/23/2014)... GBI Research, the leading business intelligence provider, has ... Developed Markets to 2020 - New and Late-Stage Four-Factor ... in-depth analysis of the critical care market in the ... The report provides an estimation of market size for ... critical care indications that are being treated using the ...
(Date:8/23/2014)... 2014 Dealing with a drug or alcohol ... the addict is a child. Adolescent addiction has been an ... time, but a new helpline is now providing a valuable ... to find a real addiction recovery center. , The Troubled ... impact in the community. By calling (404) 975-2762, parents and ...
(Date:8/22/2014)... Search Engine Optimization is needed ... of search engines and get more audience and ... compared many Linux hosting suppliers and announced that ... most recommended Linux hosting suppliers for webmasters from ... buy high quality Linux hosting (including VPS and ...
(Date:8/22/2014)... Park City, UT (PRWEB) August 22, 2014 ... Solution, published a new guide on Account-Based Health Plans. ... health plans (ABHPs) as a strategy to lower the ... the different types of medical spending accounts, however, can ... easy-to-understand comparison chart to learn the four main types ...
Breaking Medicine News(10 mins):Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 2Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 3Health News:Atlanta’s New Troubled Teen Helpline Is Making a Difference in the Community 2Health News:Top10BestSEOHosting.com Announces Best Cheap Hosting Suppliers Of This Summer 2
... diseased human bone marrow to become embryonic-like stem cells, ... for observing the onset of the blood cancer leukemia ... reprogramming of blood cells obtained from a patient with ... Slukvin, who directed a study aimed at generating all-purpose ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, Feb. 3 ... the U.S. population, they account for 50.3 percent of all diagnosed ... of HIV diagnosis among black men is eight times that of ... of whites, finds a new analysis of data from 37 ...
... -- About 340,000 cancer cases in the United States could ... diet, got regular exercise and limited their alcohol intake, according ... of lifestyle changes could lead to significant reductions in particularly ... year), stomach (47 percent fewer) and colon (45 percent fewer). ...
... , THURSDAY, Feb. 3 (HealthDay News) -- If ... the Super Bowl, there are some simple things you can ... next day, says an expert. Gastroenterologist Dr. Cynthia Yoshida ... every alcoholic beverage with a non-alcoholic drink. Caffeine-free, non-carbonated drinks, ...
... Jenifer Goodwin HealthDay Reporter , THURSDAY, Feb. ... to lose weight, gastric bypass surgery seems to help ... and appearance, a new study suggests. Obesity is ... including heart failure, atrial fibrillation (an abnormal heart rhythm) ...
... HealthDay Reporter , THURSDAY, Feb. 3 (HealthDay News) -- ... appear to lose mobility faster than men, new research reveals. ... peripheral arteries, usually those in the legs and pelvis. The ... leg or hip muscles when walking or climbing stairs -- ...
Cached Medicine News:Health News:New induced stem cells may unmask cancer at earliest stage 2Health News: Burden of HIV Highest for Blacks, CDC Reports 2Health News: Burden of HIV Highest for Blacks, CDC Reports 3Health News:Healthier Lifestyles May Prevent 340,000 U.S. Cancers a Year: Study 2Health News:Weight-Loss Surgery May 'Remodel' Heart 2Health News:Weight-Loss Surgery May 'Remodel' Heart 3Health News:Narrowed Leg Arteries Disable Women Faster Than Men: Study 2Health News:Narrowed Leg Arteries Disable Women Faster Than Men: Study 3
The Astigmatome makes precise and accurate cuts for astigmatism correction simply and safely....
The Astigmatome makes precise and accurate cuts for astigmatism correction simply and safely. The procedure can be done in the office under topical anesthesia. Template Set 10mm Set. Includes 0 - 360...
... Medtronic presents the Streamline family of temporary ... taken the gold standard in temporary pacing ... make them easy to use and less ... Temporary Pacing Leads are designed to provide ...
... Carpentier-Edwards Classic annuloplasty rings have ... choice for more than 30 ... restore the anatomical size and ... to help prevent recurrent dilatation. ...
Medicine Products: