Navigation Links
Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia
Date:6/26/2008

mean TST during the first third of the night improved by 45.2 minutes in the 20mg group (p<.001), by 40.1 minutes in the 50mg group (p<.01), and by 30.6 minutes in the placebo group. All statistical comparisons are between tasimelteon dose versus placebo.

-- Mean WASO during the first third of the night at baseline (before drug treatment) was 20.8 minutes in the 20mg group, 21.3 minutes in the 50mg group, and 21.3 minutes in the placebo group. On Nights 1 and 8 of treatment, mean WASO during the first third of the night improved by 2.3 minutes in the 20mg group (p<.01), and by 1.8 minutes in the 50mg group (p<.05), but worsened by 3.1 minutes in the placebo group. On Nights 22 and 29 of treatment, mean WASO during the first third of the night improved by 3.1 minutes in the 20mg group (nss), by 1.8 minutes in the 50mg group (nss) and by 0.6 minutes in the placebo group. All statistical comparisons are between tasimelteon dose versus placebo.

These results reveal that tasimelteon was able to achieve a number of statistically significant improvements on sleep maintenance parameters during the portion of the night in which the patient population studied suffered the greatest impairment. These data are consistent with data from the prior Phase III study (VP-VEC-162-3101), in which 20mg and 50mg of tasimelteon significantly improved LPS (by 21.5 to 26.3 minutes compared to placebo), WASO (by 24.7 to 33.7 minutes compared to placebo), and TST (by 33.7 to 47.9 minutes compared to placebo) in a model of transient insomnia. Taken together, the results of both of these studies demonstrate the versatility of tasimelteon to treat the symptoms of insomnia acutely and chronically both in a model of transient insomnia and in patients with chronic primary insomnia.

"These results suggest that circadian misalignment may play an important role in the pathophysiology of chronic primary insomnia in many patients, especially those who have difficulty falling asleep,"
'/>"/>

SOURCE Vanda Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014   BioNano Genomics , the genome ... centers to purchase an Irys™ System . Among ... Institute (NCI), NIH Intramural Sequencing Center (NISC) and Genoscope ... a comprehensive view of a genome was a ... not deliver the scalability or reliability to detect ...
(Date:10/22/2014)... Calif. , Oct. 21, 2014 Influenza will ... flu-associated deaths in the United States ... viruses are thought to spread is from person to person ... Ebola has a serve way of death, but kills much ... Ebola is also done by human fluids including sweat, saliva, ...
(Date:10/22/2014)... Oct. 22, 2014 Sanomedics International Holdings, Inc. ... by Global Research & Data Services, demand for thermometers ... 2014 through 2018, as demand for more accurate digital ... is the world,s largest market for thermometers, and one ... is Sanomedics International Holdings, Inc. Sanomedics International ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2
... 2011 For the second year in a row Royce ... Associates, received a supplier recognition from Carestream Health, the world,s ... Carestream Health, which supplies a complete line of Medical and ... Royce their 2010 Supplier of the Year , Carestream,s ...
... 2011 Transgenomic, Inc. (OTC/BB: TBIO) today reported financial results for ... update. First Quarter Financial Results ... $7.5 million, an increase of 37 percent compared with $5.4 million ... or 56 percent of net sales, compared with gross profit of ...
Cached Medicine Technology:Royce Receives Coveted Medical Products Award 2Transgenomic Reports First Quarter Financial Results 2Transgenomic Reports First Quarter Financial Results 3Transgenomic Reports First Quarter Financial Results 4Transgenomic Reports First Quarter Financial Results 5Transgenomic Reports First Quarter Financial Results 6Transgenomic Reports First Quarter Financial Results 7Transgenomic Reports First Quarter Financial Results 8Transgenomic Reports First Quarter Financial Results 9
(Date:10/22/2014)... Steven Reinberg HealthDay Reporter ... quickly add weight and length may be showing a genetic ... In adults, certain genes have been linked to increased body ... in fat and lean muscle, the researchers said. At ... taller. By ages 2 and 3, however, these genes were ...
(Date:10/22/2014)... By Tara Haelle ... -- Binge drinking among young adult men may lead to ... binge drinking didn,t cause a similar rise in blood pressure ... study. In fact, when young adult women drank lightly or ... half, the study found. "This finding parallels studies in ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. ... officially tightened guidelines for health workers treating Ebola patients, now ... of a respirator at all times. The U.S. Centers ... rules after two Dallas nurses contracted Ebola while caring for ... national Thomas Eric Duncan. Nina Pham is currently being treated ...
(Date:10/20/2014)... October 20, 2014 With a mere ... Charlie Crist made a brief fundraising stop at the ... Thursday. , Fresh from a debate last night with ... the stage for the first seven minutes because Crist ... governor described the incident in one word: "weird." , ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ASCNYC ... organization that helps New Yorkers living with HIV/AIDS ... toward health, housing, recovery and self-sufficiency. Each year, ... the local community through their tireless efforts. , ... Marc Shapses , has been selected as this ...
Breaking Medicine News(10 mins):Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3
... as medication rid brain of matted protein, researchers say , , ... aims to reduce the clogging "tangles" in the brain cells ... researchers report. , Further studies are necessary to confirm whether ... seems, or whether it needs to be given as part ...
... Former U.S. Surgeon General,Julius B. Richmond, MD, FAAP, a ... Sunday, July 27, 2008, of,cancer at his home near ... President Carter,s Assistant Secretary for,Health and as U.S. Surgeon ... reinvigorated tobacco control efforts through the release of,the 1979 ...
... Md., July 29 Sanaria Inc., a,privately ... University of,Maryland Biotechnology Institute (UMBI) announced the ... (SBIR) Grant from the,National Institute of Allergy ... of Health. The grant will support research ...
... Genomma Lab,Internacional, S.A.B. de C.V. (BMV: LAB) ("Genomma" ... personal care products,company announced yesterday that it had ... UNIGASTROZOL, from Unipharm de Mexico, S.A. de,C.V. This ... control of,gastrointestinal symptoms that are produced by excessive ...
... safety, reliable results , , TUESDAY, July 29 (HealthDay News) ... cancer care and research, but most tests aren,t administered ... Medical Center researchers. , In cancer care, exercise tests ... cancer patients. In cancer research, exercise tests are most ...
... Corporate Officer of Gillette, brings 38 years of ... experience in consumer products industry, CHICAGO, ... announced today that Peter Klein has joined the,firm as a ... the global consumer products,industry and was most recently senior vice ...
Cached Medicine News:Health News:'De-Tangling' Alzheimer's Drug Shows Promise 2Health News:'De-Tangling' Alzheimer's Drug Shows Promise 3Health News:'De-Tangling' Alzheimer's Drug Shows Promise 4Health News:Former U.S. Surgeon General Julius B. Richmond, 91 2Health News:Former U.S. Surgeon General Julius B. Richmond, 91 3Health News:Malaria Vaccine Developer Sanaria Inc. and the University of Maryland Biotechnology Institute Awarded Collaborative, Multi-Year, US $600,000 NIH Phase I Small Business Innovation Research Grant 2Health News:Malaria Vaccine Developer Sanaria Inc. and the University of Maryland Biotechnology Institute Awarded Collaborative, Multi-Year, US $600,000 NIH Phase I Small Business Innovation Research Grant 3Health News:Genomma Lab Internacional Acquires UNIGASTROZOL 2Health News:Exercise Testing for Cancer Fails to Follow Guidelines 2Health News:The Cambridge Group Names Peter Klein a Director 2
... Featuring an expanded database containing over ... identification cards, VITEK 2 Compact offers ... amount of time (2 to 14 ... of microorganisms that contaminate production areas ...
... transmitting data from multiple sources is ... Dawnings ResultNet/Plus software allows you to ... your communications network., ,ResultNet/Plus eliminates the ... from largescale or multi-site laboratories to ...
... Software is a powerful Java-based interface ... to control laboratory instrument connections and ... used in two applications: embedded in ... on a network PC station. Within ...
Powerful LED Illumination , The ultrabright and compact 3S LED HeadLight from HEINE for Powerful, coaxial illumination...
Medicine Products: