Navigation Links
Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia
Date:6/26/2008

mean TST during the first third of the night improved by 45.2 minutes in the 20mg group (p<.001), by 40.1 minutes in the 50mg group (p<.01), and by 30.6 minutes in the placebo group. All statistical comparisons are between tasimelteon dose versus placebo.

-- Mean WASO during the first third of the night at baseline (before drug treatment) was 20.8 minutes in the 20mg group, 21.3 minutes in the 50mg group, and 21.3 minutes in the placebo group. On Nights 1 and 8 of treatment, mean WASO during the first third of the night improved by 2.3 minutes in the 20mg group (p<.01), and by 1.8 minutes in the 50mg group (p<.05), but worsened by 3.1 minutes in the placebo group. On Nights 22 and 29 of treatment, mean WASO during the first third of the night improved by 3.1 minutes in the 20mg group (nss), by 1.8 minutes in the 50mg group (nss) and by 0.6 minutes in the placebo group. All statistical comparisons are between tasimelteon dose versus placebo.

These results reveal that tasimelteon was able to achieve a number of statistically significant improvements on sleep maintenance parameters during the portion of the night in which the patient population studied suffered the greatest impairment. These data are consistent with data from the prior Phase III study (VP-VEC-162-3101), in which 20mg and 50mg of tasimelteon significantly improved LPS (by 21.5 to 26.3 minutes compared to placebo), WASO (by 24.7 to 33.7 minutes compared to placebo), and TST (by 33.7 to 47.9 minutes compared to placebo) in a model of transient insomnia. Taken together, the results of both of these studies demonstrate the versatility of tasimelteon to treat the symptoms of insomnia acutely and chronically both in a model of transient insomnia and in patients with chronic primary insomnia.

"These results suggest that circadian misalignment may play an important role in the pathophysiology of chronic primary insomnia in many patients, especially those who have difficulty falling asleep,"
'/>"/>

SOURCE Vanda Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... --  Rock Creek Pharmaceuticals, Inc., (NASDAQ: ... present at the Biotech Showcase™ 2015 taking place in ... 12-14, 2015. Michael Mullan , ... will present preclinical and clinical data for anatabine citrate, ... characteristics. Dr. Mullan will outline the Company,s regulatory strategy ...
(Date:11/21/2014)... November 2014 Clementia ... gegeben, dass die Europäische Arzneimittel-Agentur (European ... als Orphan-Medizinprodukt an Palovarotene vergeben hat, ... Behandlung von Fibrodysplasia ossificans progressiva (FOP). ... genetische Krankheit, die von schmerzhaften, wiederkehrenden ...
(Date:11/21/2014)... FALLS, N.J. , Nov. 20, 2014 /PRNewswire/-- CANTEL MEDICAL CORP. ... A. Krakauer , Chief Executive Officer, will be presenting at ... The New York Palace Hotel in New York ... 2, 2014 at 2:00 PM ET. In addition, Mr. Krakauer ... be available for separate one-on-one meetings during the day. ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 3Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 4Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3
... Reportlinker.com announces that a new ... its catalogue: Orthopedic ... (China, India, Brazil) - Presenting New ... http://www.reportlinker.com/p0491878/Orthopedic-Devices-Market-in-the-Emerging-Countries-China-India-Brazil---Presenting-New-Avenues-for-Growth-and-Profitability.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic ...
... Scientific Pte. Ltd today announced that it will be exhibiting ... anticipated CE Mark approval this year for TIGR® Matrix ... Synthetic Mesh. To mark the occasion, a special ... the Zebrastraat venue in Ghent  ( http://www.novusscientific.com/events/ ), featuring renowned ...
Cached Medicine Technology:Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 2Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 3Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 4Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 5Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 6Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 7Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 8Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 9Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 10Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 11Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 12Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 13Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 14Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 15Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 16Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 17Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 18Reportlinker Adds Orthopedic Devices Market in the Emerging Countries (China, India, Brazil) - Presenting New Avenues for Growth and Profitability 19TIGR® Matrix Surgical Mesh - Exhibited Ahead of Anticipated CE Mark Approval at European Hernia Society 2011, Ghent, Belgium 2
(Date:11/22/2014)... PrettyTailor , an outstanding dress ... big promotion. Customers can buy new dresses at its ... visit its website. , As a matter of fact, ... It mainly provides four types of wedding outfits, including ... girl dresses. It also provides a variety of occasion ...
(Date:11/22/2014)... is a famous brand in the bamboo flooring industry. ... bamboo mats ; the new models are offered now ... According to the sales manager of BambooFlooringChina.com, Bamboo is a ... resource. Their bamboo mats are 100% made from natural bamboo. ... bamboo with caramel bamboo strips. , “Bamboo mats ...
(Date:11/22/2014)... Discount-Dress.com is an important company ... is to increase the company’s online market share by a ... of bridesmaid dresses and announced a bridesmaid dress promotion for ... Dec. 30, 2014. All the dresses from this company are ... In fact, Discount-Dress.com is very good at manufacturing wedding dresses. ...
(Date:11/22/2014)... New York, New York (PRWEB) November 22, 2014 ... use of power morcellators ( http://www.morcellatorlawsuit2015.com ) in ... than 450 new signatures since the end of October, ... people had signed the petition as of November 21st, ... October 31st, when 86,042 supporters had signed on to ...
(Date:11/22/2014)... New York, New York (PRWEB) November 22, 2014 ... been filed on behalf of patients who allegedly developed ... move forward in the federal multidistrict litigation now underway ... Liebhard LLP reports. According to court documents, the litigation ... at 10:00 a.m. The Court has directed Lead Counsel ...
Breaking Medicine News(10 mins):Health News:Customers Are Welcome to Shop at PrettyTailor.com 2Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2Health News:Power Morcellator Petition Gains More than 450 Signatures Since October, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Petition Gains More than 450 Signatures Since October, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Petition Gains More than 450 Signatures Since October, Bernstein Liebhard LLP Reports 4Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3
... TOWN, South Africa, May 11 ... feel the effects of the global economic slowdown. ... rising health costs and constrained healthcare resources.(Logo: ... are those whose economies are largely driven by ...
... Firm Recognizes Efforts in Patient Satisfaction , ... South ... Press Ganey Associates, Inc., is proud to recognize all of ... of care they provide., , , , ,“The doctors, nurses, and ...
... May 11 , - Health of the Nation has ... - Britain is Overwhelmed, Overworked and Overweight, - 1.9 ... The nation appears to be stuck in a downward ... time and,money by cutting back on exercise and healthy foods in the ...
... likely than men to feel the pinch of rising ... (52%) of working-age women reporting problems accessing needed care ... a new Commonwealth Fund study finds. Women who are ... percent of underinsured women have problems accessing care because ...
... The winners of today,s Susan G. Komen Pittsburgh Race ... Winners , Male: Pat McGuire, Greensburg, Pa., 15:35 ... Place Overall Winners , Male: Steven Strelick, 16:05 ... Overall Winners , Male: Charlie Ban, Pittsburgh, ...
... Increased strain on the system will increase misdiagnosis or late diagnosis of ... Gurfein Douglas LLP , ... New York, NY (PRWEB) May 10, 2009 ... will not only cause delays in breast, colon and cervical cancer screening ...
Cached Medicine News:Health News:Not All Gloomy for African Healthcare Markets: Frost & Sullivan Finds Potential Despite the Recession 2Health News:Not All Gloomy for African Healthcare Markets: Frost & Sullivan Finds Potential Despite the Recession 3Health News:Press Ganey Supports National Hospital Week 2Health News:Press Ganey Supports National Hospital Week 3Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 2Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 3Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 4Health News:7 of 10 women are uninsured or underinsured, or have medical bill, debt, access problems 2Health News:7 of 10 women are uninsured or underinsured, or have medical bill, debt, access problems 3Health News:17th Annual Komen Pittsburgh Race for the Cure(R) 5K Winners Announced 2Health News:Budget Cuts for Free Cancer Screening Clinics in New York Could Put Patients' Lives at Risk, Says New York Medical Malpractice Lawyer 2Health News:Budget Cuts for Free Cancer Screening Clinics in New York Could Put Patients' Lives at Risk, Says New York Medical Malpractice Lawyer 3Health News:Budget Cuts for Free Cancer Screening Clinics in New York Could Put Patients' Lives at Risk, Says New York Medical Malpractice Lawyer 4
The Dolphin Medical 2150 Pulse Oximeter consists of the Dolphin ONE OEM 701 Module technology, (1) extension cable, and (1) oximetry sensor to non-invasively calculate the functional saturation of ar...
All-in-One Fingertip Oximeter...
... The Invacare Sleep Printing ... specifically designed to address ... a device that can ... conducting overnight screening for ...
The reliable and easy-to-use 3900/P pulse oximeter is now more advanced - featuring TruTrak+ technology, the proprietary clinical motion algorithm from Datex+-Ohmeda....
Medicine Products: