Navigation Links
Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia
Date:6/26/2008

Study Meets Primary Endpoint, with Positive Effect Sustained Through

Duration of 4-Week Study

ROCKVILLE, Md., June 26 /PRNewswire-FirstCall/ -- Vanda Pharmaceuticals Inc. (Nasdaq: VNDA) (Vanda) today announced positive top-line results from a Phase III trial showing that its investigational drug candidate, tasimelteon (VEC-162), a novel melatonin agonist, met the primary endpoint of the trial and significantly improved sleep in adult patients with chronic insomnia.

"We are excited that the results of this Phase III chronic insomnia study demonstrate the clinical utility of tasimelteon and the ability of the compound to treat sleep disorders over a period of four weeks. The mechanism of action of tasimelteon as a circadian regulator gives Vanda the opportunity to explore its use for the treatment of circadian rhythm sleep disorders as well as chronic primary insomnia," stated Paolo Baroldi, MD, PhD, Vanda's Chief Medical Officer.

This Phase III, multi-center, placebo-controlled, 4-week trial evaluated 322 patients with chronic primary insomnia. Patients were randomized to receive either 20 mg or 50 mg of tasimelteon or placebo over the course of four weeks. The primary endpoint consisted of the evaluation of the immediate and short-term (average of Nights 1 and 8) ability of tasimelteon to improve sleep onset as measured by Latency to Persistent Sleep (LPS) through polysomnography (PSG). Secondary endpoints evaluated tasimelteon's ability to maintain improvements on sleep onset after long-term (average of Nights 22 and 29) use of the compound as well as measures of sleep duration (Total Sleep Time, TST) and sleep maintenance (Wake After Sleep Onset, WASO). Patients were eligible for the stud
'/>"/>

SOURCE Vanda Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... 2015 Research and ... of the "12th Annual Report and Survey ... to their offering. The 2015 12th ... and Production is the most recent study of ... projected future capacity and production. The report contains ...
(Date:8/28/2015)... Aug. 28, 2015 ... addition of the "Investigation Report on China,s ... offering. Developed by Novo Nordisk, insulin ... an important drug for the treatment of diabetes. ... fast- acting insulin analog, starts working fast and ...
(Date:8/28/2015)... , Aug. 28, 2015 Perrigo Company plc ... the Mylan N.V. ("Mylan") (NASDAQ: MYL ) shareholder ... "Our views of Mylan,s offer to Perrigo ... based on our Board,s careful reflection of the value ... the limited choices that Mylan has allowed its shareholders ...
Breaking Medicine Technology:12th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production 2China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5
... Scientific Corporation (NYSE: BSX ) will webcast its ... year ended December 31, 2010 on Wednesday, February 2, at ... by Ray Elliott, President and Chief Executive Officer, and Jeff ... The live webcast and archived replay of this call will ...
... 19, 2011 Wolters Kluwer Health today announced ... Medicom to deliver clinical decision support to doctors in ... its healthcare system. The deal allows Wolters Kluwer Health ... drug information business into the rapidly growing China market ...
Cached Medicine Technology:Boston Scientific to Webcast Conference Call Discussing Fourth Quarter and Full Year 2010 Financial Results 2Wolters Kluwer Health Enters Joint Venture with China Drug Information Provider Medicom 2Wolters Kluwer Health Enters Joint Venture with China Drug Information Provider Medicom 3
(Date:8/28/2015)... ... August 28, 2015 , ... ... and Best Practices for Compliance, **Presented by FDAnews and GessNet**, Oct. 14-15, ... internationally renowned expert Fubin Wu, has been specifically designed to provide devicemakers ...
(Date:8/28/2015)... ... August 28, 2015 , ... On May 30th, 2015, Best ... sponsor of the “Music With A Mission” benefit concert in Mendon, IL. Held in ... to raise money to support music education programs in the underfunded local school districts ...
(Date:8/28/2015)... ... 2015 , ... “ Frequentz ” was featured on NewsWatch as part of ... the market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch and ... businesses to track product movement from beginning to end. , Businesses benefit greatly from ...
(Date:8/28/2015)... ... August 28, 2015 , ... Medical Solutions, one of the nation’s largest travel ... in Healthcare by Modern Healthcare and will be honored at an awards dinner ... year, the Best Places to Work in Healthcare program recognizes outstanding employers in the ...
(Date:8/28/2015)... ... ... Dr. Gregory K. Toumayan, D.C., Q.M.E., is now treating patients with back pain and ... neck pain, stiffness, muscle spasms, and numbness. , Dr. Toumayan received his Bachelor ... to earn his title of Doctor of Chiropractic from the Palmer College of Chiropractic ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2Health News:Track Product Movement from Beginning to End with Frequentz 2Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 2Health News:Medical Solutions Recognized as One of 2015 Best Places to Work in Healthcare 3Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3
... 2 Diabetes who are at an increased risk of developing ... blindness . New Wesley Research Institute project aims to make ... Diabetes by using community pharmacists. ,Chief investigator of ... this study had the potential to benefit sufferers by enabling ...
... access journal BMC Public Health suggest that the acetaminophen (paracetamol) ... the decade to 2004 , without a change to the ... the UK. young women, Aboriginals and those on social ... Calgary, Canada team led by Dr. Robert Myers used administrative ...
... Sets Out to Weed Through The Jungle of Plans If you ... have been exposed to multiple diet pitches in your life. ... extracts from Indonesia has been pitched to the greater community at ... called diet plans that often lead to nothing but frustration. ...
... at high-risk of having a heart attack are unclear about ... call an ambulance , argue a group of heart specialists ... people who die from coronary heart disease have had previous ... Heart Foundation shows that 40% of the general population would ...
... University engineers are working to make the traffic control boxes ... developed new software that helps the computerized boxes locate road ... notify transportation authorities at lower cost, especially in rural areas. ... savings could add up to tens of thousands of dollars ...
... sickening erotica fantasies, two US teenagers in the Florida state ... woman, forcing her 12-year-old son to join the outrage , ... ,Authorities allege Avion Lawson, 14, and Nathan Walker, ... who forced their way into the woman's apartment in a ...
Cached Medicine News:Health News:Deep Insights into Type2 Diabetes by Wesley Researchers 2Health News:Overdose of Paracetamol was Dropped 2Health News:Frustrated With Fad Diets One Man Sets Out to Weed Through The Jungle of Plans 2Health News:High-risk Patients Need Better Guidance on What is and Isnt a Heart Attack 2Health News:Traffic Control Boxes to Help Road Monitoring 2Health News:Traffic Control Boxes to Help Road Monitoring 3Health News:Traffic Control Boxes to Help Road Monitoring 4Health News:Traffic Control Boxes to Help Road Monitoring 5Health News:US Teens Charged With Gang Raping a Woman 2Health News:US Teens Charged With Gang Raping a Woman 3
... line of Surgical Access ...unlike any trocar ... trocar system is actually four systems in ... flexible and clinically adaptive to all of ... disposability and bladed or dilating tip styles, ...
Thoracoscopy Cannula, reusable, hook electrode, two lengths, mini or basic kit....
... we believe that the trocar should be ... instrument precision and speeding the process. So ... trocar that meets the needs of the ... Xcel - The only trocar that affords ...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Medicine Products: