Navigation Links
Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia
Date:6/26/2008

Study Meets Primary Endpoint, with Positive Effect Sustained Through

Duration of 4-Week Study

ROCKVILLE, Md., June 26 /PRNewswire-FirstCall/ -- Vanda Pharmaceuticals Inc. (Nasdaq: VNDA) (Vanda) today announced positive top-line results from a Phase III trial showing that its investigational drug candidate, tasimelteon (VEC-162), a novel melatonin agonist, met the primary endpoint of the trial and significantly improved sleep in adult patients with chronic insomnia.

"We are excited that the results of this Phase III chronic insomnia study demonstrate the clinical utility of tasimelteon and the ability of the compound to treat sleep disorders over a period of four weeks. The mechanism of action of tasimelteon as a circadian regulator gives Vanda the opportunity to explore its use for the treatment of circadian rhythm sleep disorders as well as chronic primary insomnia," stated Paolo Baroldi, MD, PhD, Vanda's Chief Medical Officer.

This Phase III, multi-center, placebo-controlled, 4-week trial evaluated 322 patients with chronic primary insomnia. Patients were randomized to receive either 20 mg or 50 mg of tasimelteon or placebo over the course of four weeks. The primary endpoint consisted of the evaluation of the immediate and short-term (average of Nights 1 and 8) ability of tasimelteon to improve sleep onset as measured by Latency to Persistent Sleep (LPS) through polysomnography (PSG). Secondary endpoints evaluated tasimelteon's ability to maintain improvements on sleep onset after long-term (average of Nights 22 and 29) use of the compound as well as measures of sleep duration (Total Sleep Time, TST) and sleep maintenance (Wake After Sleep Onset, WASO). Patients were eligible for the stud
'/>"/>

SOURCE Vanda Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)...  Surgical Theater LLC ha annunciato oggi ... l,apertura in data 24 novembre del primo ... IRCCS Istituto Neurologico Nazionale "C. Besta". I ... pianificazione chirurgica) e Surgical Navigation Advanced Platform ... presentati in occasione dell,evento dedicato alle loro ...
(Date:11/24/2014)... 2014  Inovio Pharmaceuticals, Inc. (NASDAQ: INO ) ... and CEO of Inovio Pharmaceuticals, will be joined by members ... Nasdaq Opening Bell tomorrow, Tuesday November 25, 2014, at 9:30 ... listing on the Nasdaq Global Select Market.  ... are honored to ring the Nasdaq Opening Bell on behalf ...
(Date:11/23/2014)... N.J. , Nov. 23, 2014  Aurobindo Pharma ... GESB14011-A of Gabapentin Capsules, USP 300 mg 100-count bottles ... found to contain some empty capsules. Empty ... in adverse health consequences that could range from no ... effect, or status epilepticus (long period seizures) that could ...
Breaking Medicine Technology:La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 2La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 3La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 4Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 2Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 3Aurobindo Pharma USA, Inc. Issues Voluntary Nationwide Recall of Northstar Label Gabapentin Capsules, USP 300 mg Due to Complaints of Empty Capsules 2
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced that it ... overview, as well as to discuss first quarter 2010 financial results, on ... 2:00 p.m. Pacific Time ).  Financial results for the first quarter ended ... , , ...
... , MINNEAPOLIS , April 27 ATS ... state-of-the-art cardiac surgery products and services, today announced participation in ... Thoracic Surgeons (AATS) being held in Toronto, Canada , ... is a key gathering of cardiovascular surgeons, nurses and allied ...
Cached Medicine Technology:Onyx Pharmaceuticals Announces First Quarter 2010 Financial Results Teleconference and Webcast 2ATS Medical Announces Participation in the 90th Annual Meeting of the American Association for Thoracic Surgeons 2ATS Medical Announces Participation in the 90th Annual Meeting of the American Association for Thoracic Surgeons 3ATS Medical Announces Participation in the 90th Annual Meeting of the American Association for Thoracic Surgeons 4
(Date:11/26/2014)... By Steven Reinberg ... -- New rules announced Tuesday by the U.S. Food and ... on their menus, and the rules even apply to movie ... about a third of their calories away from home, often ... FDA commissioner Dr. Margaret Hamburg said during a Monday afternoon ...
(Date:11/24/2014)... 2014 The Healthy Skin Care Journal, ... affordable skin care products, recently announced its launch. Located ... a wide variety of articles, tips, and evaluations about ... skincare alternatives. , According to Emily Lataille, the website’s ... includes thoroughly researched reviews, tips for the skin, and ...
(Date:11/24/2014)... Residents of retirement communities in Ohio ... SENIORS GOT TALENT, an annual online talent competition and ... to classic crooners, to seniors partying on a “night ... indeed living young. , “SENIORS GOT TALENT, while still ... prize, has always been about highlighting the vibrancy of ...
(Date:11/24/2014)... SWAccessControl.com has recently released a ... of fact, the company is a leading online supplier in ... locks are available at discounted prices, up to 30% off. ... magnetic locks. This time, all of our items are offered ... and abroad, so I have confidence in our fresh assortment. ...
(Date:11/24/2014)... November 24, 2014 Gersowitz Libo & Korek, ... has received national Tier recognition in the 2015 Edition of ... tiered ranking signals a unique combination of quality law practice ... to receive this honor and especially grateful to our clients ... honor and ranking possible,” said Jeff S. Korek, senior partner ...
Breaking Medicine News(10 mins):Health News:Calorie Counts Mandated at Chain Restaurants, FDA Says 2Health News:Calorie Counts Mandated at Chain Restaurants, FDA Says 3Health News:Skin Care Advice Blog The Healthy Skin Care Journal Now Accessible to the Public 2Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 2Health News:Nursing Homes & Assisted Living Retirement Communities Enter Seniors Guide's Seniors Got Talent 3Health News:SWAccessControl.com Is Happy To Release New Range Of Magnetic Locks 2Health News:U.S. News-Best Lawyers “Best Law Firms” Names Gersowitz Libo & Korek P.C. a 2015 Tier 1 Ranking Firm 2
... Emergency Stand Alone switch provider sees telcos looking to find,viable solutions for improving public safety and network resiliency for ... Americans, BOULDER, Colo., April 3, ... CEO Aztek Networks ( http://www.azteknetworks.net ... more than 20 years experience, Bruny has served ...
... Rhytec, Inc. the pioneer,of plasma skin regeneration and ... novel thermal energy called plasma for reversing the ... Food and Drug Administration (FDA),clearance to market a ... already cleared by the FDA for treating facial ...
... The following is a,statement of William V. Corr, ... and legislative leaders have broken Ohio,s,promise to protect its ... the state,s highly successful tobacco prevention program, run by ... price if this raid,is carried out. More kids will ...
... 2, 2008 Grubb &,Ellis Healthcare REIT, Inc. today ... Located at 3035, 3037, 3131, and 3133 Lakeland ... of four identical buildings. Each,building has approximately 8,000 square ... in 1996 and 1998 on approximately 4.64,acres, the buildings ...
... Blunt (Mo.) issued the following statement today after the ... AIDS initiative -,even though the president himself only requested ... program couldn,t spend in 10,years what the majority believes ... than one occasion that the president,s initiative on,fighting HIV/AIDS ...
... Latest Data Shows Number of Eye Disease Patients ... Americans are currently,living with age-related eye disease and, ... and the National Eye Institute, that number,is continuing ... aged 40 and,older, more than 30 million suffer ...
Cached Medicine News:Health News:Telecommunications Carriers Respond To Congress' Declaration of April as National 9-1-1 Education Month 2Health News:Telecommunications Carriers Respond To Congress' Declaration of April as National 9-1-1 Education Month 3Health News:Portrait(R) Plasma Receives Clearance from the FDA to Treat Acne Scars 2Health News:Portrait(R) Plasma Receives Clearance from the FDA to Treat Acne Scars 3Health News:Gov. Strickland, Legislative Leaders Break Promise to Protect Ohio's Kids from Tobacco 2Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 2Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 3Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 4Health News:Eye Disease Continuing to Increase Among Americans 2Health News:Eye Disease Continuing to Increase Among Americans 3
... patients come to you with concerns ... can understand. Then they want treatment. ... Assessment System can you gather, evaluate, ... and tumescence data...and provide the answers ...
The very bright medical maginifier lamp for examination and labratory....
... These powdered surgical gloves were designed ... Plus delivers comfort, barrier protection, and value. ... for both wet and dry hands. The ... fit, while the micro-rough surface offers sensitivity ...
... distinctive COLOR PURPLE* distinguish SAFESKIN* PURPLE ... sterile clinical procedures when an exceptionally ... designed as an alternative for individuals ... hypersensitivity to natural rubber latex proteins. ...
Medicine Products: