Navigation Links
Phase III Data Demonstrate Efficacy and Tolerability of Carisbamate as an Adjunctive Therapy for Partial Onset Seizures
Date:12/6/2008

the 12-week double blind phase.

Carisbamate was well tolerated, with minimal central nervous system-related adverse events and a low discontinuation rate. The most common adverse events were dizziness and somnolence. The rate of treatment-emergent adverse events resulting in discontinuation from carisbamate was 3% in each study. Results showed that treatment with carisbamate 400 mg resulted in significant improvement in both efficacy measures compared with placebo in study 1, but not in study 2. Carisbamate 200 mg/day did not differ from placebo in either study. In both studies, concomitant use of enzyme-inducing AEDs lowered plasma levels of carisbamate by up to 44% (40% in study 1 and 44% in study 2). As a result, there were greater percentage reductions in POS frequency among patients treated with carisbamate who received concomitant non-enzyme inducing AEDs.

PK/PD Modeling of the Effect of Carisbamate

A second poster showed results of an analysis of three studies, which evaluated the efficacy of carisbamate, using a PK/PD model to predict the effect of carisbamate over a dose range of 400 mg/day to 1200 mg/day. The relationship between percent reduction of POS from baseline and steady state trough concentration was investigated.

The model showed that seizure reduction increased with greater drug exposure levels. Carisbamate pharmacokinetics were influenced by the co-administration of enzyme-inducing AEDs, which reduced carisbamate exposure by about 33-40%. In all three studies separately, a statistically significant positive relationship between seizure rate reduction and steady state trough concentrations was found. The PK/PD simulations predicted that treatment with 400 mg/day provides clinically meaningful effects for all subjects, with further increase in effect with dosages of 800 mg and 1200 mg/day for patients on enzyme-inducing or non-enzyme inducing AEDs.

The
'/>"/>

SOURCE Ortho-McNeil Neurologics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 /PRNewswire-iReach/ -- "United States ... provides key market data on the ... The report provides value, in millions ... units) within market categories – Bronchoscopes, ... & Gastroscopes, Duodenoscopes, Laparoscopes, Hysteroscopes, Sinuscopes, ...
(Date:9/19/2014)... -- Kiromic, LLC, a Lubbock bio-pharmaceutical ... the former chancellor of Texas Tech University, to its board ... 2014, after raising $1.2 billion for the university. ... the most successful chancellor in the history of Texas Tech ... investor, but also as our new vice chairman of the ...
(Date:9/19/2014)... 19, 2014 According to ... (Cryotherapy, Heat, therapy, Hydrotherapy), Accessories (Posture Mirror, Exercise Ball), ... technologies - Global Forecast to 2019" published by ... reach $19,786.3 Million by 2019 from $14,240.0 Million ... 2014 to 2019. Browse 74 market ...
Breaking Medicine Technology:United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4
... can be very serious for everybody. So serious, in fact, ... that nearly everyone get a flu vaccine. This is particularly ... people age, it becomes more difficult for them to fight ... of serious flu-related complications, including pneumonia, hospitalization and even death. ...
... Caremark Corporation (NYSE: CVS ) will be ... at 8:30 a.m. (ET) with analysts and investors to ... as its initial guidance for 2011. (Logo: ... call will be broadcast simultaneously through the Investor Relations ...
Cached Medicine Technology:Anthem Blue Cross and Blue Shield in Nevada Urges Seniors to Get Flu, Pneumonia Vaccines 2Anthem Blue Cross and Blue Shield in Nevada Urges Seniors to Get Flu, Pneumonia Vaccines 3Anthem Blue Cross and Blue Shield in Nevada Urges Seniors to Get Flu, Pneumonia Vaccines 4
(Date:9/22/2014)... In CHAMPS Patient Experience's most recent blog post, ... Meeting , Toya Gorley shares her thoughts on the ... Leader’s Board meeting this summer, which was comprised of ... to be exhilarating! Many topics were discussed, including:, ... the patient experience , Technology solutions ...
(Date:9/22/2014)... well-known wedding dress manufacturer and retailer, has recently announced a ... In addition, the company has also deiced to launch a ... in the new range is now provided with a deeply ... has thousands of unique special occasion outfits for sale; almost ... Its products are brand new and made with soft materials. ...
(Date:9/21/2014)... smoke, those using e-cigarettes (in addition to traditional cigarettes) ... to have quit smoking traditional cigarettes than non-users. Published ... of the American Cancer Society, the findings raise doubts ... patients give up smoking. , Because of the risks ... be advised to quit. But the rising use of ...
(Date:9/21/2014)... Phoenix, AZ (PRWEB) September 21, 2014 ... in Phoenix Arizona announces record demand for aggressively discounted ... of accidents occurring throughout the Valley each year, it ... to have access to discounted attorney’s fees as a ... said, Hastings and Hastings has been a frontrunner when ...
(Date:9/21/2014)... likely to trigger an allergy to peanuts than raw ... The researchers say that specific chemical changes caused by ... recognised by the body,s immune system, ,priming, the body ... time it sees any peanuts. , The results might ... peanut allergies in the Western world compared to populations ...
Breaking Medicine News(10 mins):Health News:CHAMPS' Toya Gorley Discusses the Thought-Provoking Conversation at The Leader’s Board Summer Meeting 2Health News:Discounted Plus Size Wedding Dresses Available At Fancyflyingfox.com 2Health News:E-cigarettes unhelpful in smoking cessation among cancer patients 2Health News:Hastings & Hastings Announces Record Demand For Aggressively Discounted Accident Victim Attorney’s Fees 2Health News:Hastings & Hastings Announces Record Demand For Aggressively Discounted Accident Victim Attorney’s Fees 3Health News:Dry roasting could help trigger peanut allergy 2
... Rochester study helps to explain why men get liver cancer more ... pathway, by showing a direct link between the androgen receptor, which ... it relates to the deadly cancer. The study is published ... journal from the American Association for the Advancement of Science, AAAS. ...
... ... , ... today unveiled a men,s line of wallets2wear, the revolutionary new line of wearable wallets. These ... carry a man,s credit card, ID, cash and key. They are convenient, clever and comfortable., , ...
... ... out why. This sweepstakes takes the winner and three guests to the beautiful Bay Of ... trip for four for bloggers who enter the kiwi a-go-go contest. No purchase necessary. ... (PRWEB) May 20, 2010 -- ...
... have received a $3.3 million National Institutes of Health ... and language development in bilingual children who speak English ... with those who have no delays. "Spanish speakers ... and make up 79 percent of the school age ...
... ... addresses the rise of ADHD based on scientific evidence, including toxins such as pesticides, ... public , ... May 19, 2010 -- A new book on ADHD by Dr. Sanford Newmark, one ...
... likely to develop problem , WEDNESDAY, May 19 (HealthDay ... other similar medications, may prompt long-term hearing loss among ... 18 issue of the Archives of Otolaryngology -- ... of Alabama at Birmingham discuss evidence supporting an association ...
Cached Medicine News:Health News:Androgen receptor may explain male dominance in liver cancer 2Health News:Androgen receptor may explain male dominance in liver cancer 3Health News:Androgen receptor may explain male dominance in liver cancer 4Health News:Wallets2wear Now Available for Men 2Health News:Win A Trip To New Zealand For Four: The Great Kiwi Adventure and ZESPRI's Kiwi A-Go-Go Bloggers' Contest 2Health News:Researchers get $3.3 million grant to investigate language outcomes of bilingual children 2Health News:Book Delivers Latest ADHD Research, Treatments & Results 2Health News:Book Delivers Latest ADHD Research, Treatments & Results 3Health News:Viagra Linked to Hearing Loss 2
Anti-Skin Antibody (ASA) Test Kit: Pemphigus and Bullous Pemphigoid...
... Medical Professional Diagnostics is a leading provider ... and DFA test menu that includes kits ... as well as miscellaneous conjugates and components. ... a wide assortment of substrates and kit ...
... technologies and designs, the Digital ClearMag ... of the posterior pole. Using this ... previously unattainable with the binocular indirect ... and comprehensive views, helping to reduce ...
... Our ELISA products for autoimmune testing ... ELISAs, as well as specific reflex tests ... Sm, Sm/RNP, SS-A (Ro), SS-B (La), Scl-70 ... family includes a full line of products ...
Medicine Products: