Navigation Links
Phase II Results of COL-144 Presented at European Headache and Migraine Trust International Congress 2008
Date:9/6/2008

Results Demonstrate Safety and Efficacy of First-in-Class Neurally Acting

Anti-Migraine Agent (NAAMA) for the Treatment of Acute Migraine

LONDON, Sept. 6 /PRNewswire/ -- CoLucid Pharmaceuticals, Inc., an innovative biotechnology company focusing on therapies for central nervous system disorders, announced Phase II results of its lead compound COL-144 in the treatment of acute migraine. Results demonstrated that COL-144 was safe and effective in relieving migraine headaches. COL-144 is a first-in-class Neurally Acting Anti-Migraine Agent (NAAMA), which unlike triptans, exhibits anti-migraine activity without causing vasoconstriction. COL-144 is a highly potent and selective 5HT1F receptor agonist. The studies were presented in poster presentations at the European Headache and Migraine Trust International Congress 2008 in London, Sept. 4-7, 2008.

"In the Phase II study, the majority of patients experienced migraine relief 20 to 40 minutes after dosing and COL-144 was generally well-tolerated," Alison Pilgrim, BM, BCh, DPhil, chief medical officer at CoLucid, said. "The study indicates that COL-144 may be a treatment option for all patients including those who don't respond to or are contraindicated for the current standard of care."

The randomized, double-blind study evaluated 130 migraine patients. Patients were not on prophylaxis and received 2.5 to 45 mg of COL-144 or placebo as an intravenous infusion over 20 minutes as first-line treatment of an acute migraine attack. The primary end-point parameter was headache response, defined as a reduction in headache severity from moderate to severe at baseline to mild or no headache at two hours after initiation of infusion of study drug.

A higher proportion of patients showed a headache response at two hours post dose in the 10 mg, 20 mg, 30 mg and 45 mg groups compared to placebo (54.2 to 75% vs. 45.2%) with a statistically significant linear association between response rates and
'/>"/>

SOURCE CoLucid Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... DALLAS , March 26, 2015 ... Ablation Market by Procedure Volume, Technology (RF, Microwave, Cryoablation, ... Lung Cancer, Kidney Cancer, Bone Metastasis) - Global Forecasts ... is expected to reach around $462.0 Million growing at ... 91 market data tables and 57 figures spread through ...
(Date:3/26/2015)... Over-the-counter healthcare costs can be a ... new survey of store brand over-the-counter products aimed ... to diabetes, can offer significant savings for those ... Private Label Manufacturers Association, assembled a market basket ... essential for treatment of pre-diabetes and diabetes. These ...
(Date:3/26/2015)... March 26, 2015 A new survey ... comparative effectiveness research (CER) will yield improvements in ... seeing the impact of CER in the current ... survey of stakeholders shows that they view CER ... on health care and decision-making in the next ...
Breaking Medicine Technology:Tumor Ablation Market Worth $462.0 Million by 2019 2Tumor Ablation Market Worth $462.0 Million by 2019 3Tumor Ablation Market Worth $462.0 Million by 2019 4Consumers can keep over-the-counter medicine affordable by using store brands 2NPC Highlights Stakeholder Views on Comparative Effectiveness Research and the Environment for Health Care Decision-Making 2NPC Highlights Stakeholder Views on Comparative Effectiveness Research and the Environment for Health Care Decision-Making 3NPC Highlights Stakeholder Views on Comparative Effectiveness Research and the Environment for Health Care Decision-Making 4
(Date:3/27/2015)... On March 19, 2015, at ... Lions wide receiver Herman Moore, hosted “Fighting Addiction ... substance abuse, treatment options and the recent changes ... pastors, ministers and bishops from local churches as ... , “Our ‘Fighting Addiction Together’ luncheon was informative ...
(Date:3/27/2015)... 27, 2015 SMI (Silicon Microstructures, Inc.), ... has launched the SM1120 MEMS based ultra-miniature pressure sensor ... microsensor profile at only 220um x 75um provides ample ... challenging locations. With industry leading in vivo drift ... provides a broad operating pressure range from 0 to ...
(Date:3/27/2015)... Orange, CT (PRWEB) March 27, 2015 Trail ... go, after a workout, on weekend hikes and during the ... health benefits. Aurora Natural is proud to introduce a new ... your taste buds. Deliciously rich and flavorful selections packed with ... nuts, seeds, dried fruit and grains that add protein and ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 Airy Jeanine ... released the official music video for her debut song ... , Combining live-action and abstract styling effects, the thematic ... viewed on YouTube, Vimeo, and assorted outlets. It will ... development of an expanding full-scale marketing strategy. The video ...
(Date:3/27/2015)... 27, 2015 Yisrayl Hawkins, Pastor and Overseer ... only way to live in Peace is through the Laws ... article published this week. , The article titled, “Yahweh’s Way-The ... mankind and how straying away from the original biblical instructions ... the system that has been created in the world is ...
Breaking Medicine News(10 mins):Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Aurora Product, Inc. Introduces New Line of Specialty Trail Mixes 2Health News:Airy Jeanine Releases ‘’Mama’s Girl” Official Music Video 2Health News:The World Does Not Have to Continue in Misery, Says Yisrayl Hawkins in New Article 2
... finds that regularly eating broccoli sprouts may help prevent gastric ... known to cause gastritis and is believed to be a ... ,The study, conducted by a Japanese team, found that taking ... resulted in patients with H. pylori infection experiencing a significant ...
... hospital' in the country will be set up in ... ,Spread over a 10-acre plot, the Rs 125-150 crore ... headed by surgical gastro-enterologist and managing director Dr K Ravindranath. ... 150 full-time specialists in the field of liver diseases, , ...
... be developed from this year’s strain of Bird flu virus ... wild and migratory poultry and birds in Mongolia under the ... to the Wildlife Conservation Society (WCS) Veterinarian to prepare the ... The WCS team of veterinarian is spear headed by Drs. ...
... one surgeon for every one million population. There is hence ... country. This is comparatively lower when compared to the situation ... and 6000 for every one million population respectively. ... the All India Institute of Medical Sciences (AIIMS) is worried ...
... the significant causes for mortality in more than 10 million ... of total global deaths according to the World Health Organization.// ... Amongst the risk factors, the important ones are obesity, smoking, ... ,A majority of the deaths can now be prevented by ...
... New research suggests the tongue may have taste sensors dedicated ... bitter and sweet foods. ,The study, which appears ... suggests that rats and mice exhibit a spontaneous attraction for ... system is responsible for the detection of dietary lipids. The ...
Cached Medicine News:Health News:A Boon For Gastritis Patients In The Form Of Broccoli 2Health News:Global Hospitals coming to city of Joy 2Health News:Acute Shortage Of Neurosurgeons In India: One Surgeon For Every 1 Million! 2Health News:Discovery of a built-in 'fat sensor' 2
The APR Hip System offers a complete line of stems to precisely match patients' anatomic needs and address surgeon preferences....
The APR Hip System offers a complete line of stems to precisely match patients' anatomic needs and address surgeon preferences....
Simple straight stem design for the low-demand patient....
Dual offset femoral stems, hip stems that provide unique and competitive features....
Medicine Products: