Navigation Links
Phase II Data on Lilly's Antibody Show It Affects Amyloid Beta, a Protein Believed To Be Associated with Alzheimer's Disease
Date:7/30/2008

n inflammation or bleeding. As expected for a study of this duration, no change in patients' cognitive scores was observed and there was no change in levels of brain amyloid beta plaque as measured by the SPECT tracer. In addition to the increase in the two major forms of the amyloid beta protein seen in blood and cerebrospinal fluid, an increase in the two other types of the amyloid beta protein thought to be present only in amyloid plaques was observed in participants' blood and cerebrospinal fluid. The biomarker effects lasted for several weeks. These biomarker findings suggest that longer term treatment with LY2062430 may slow the clinical progression of Alzheimer's disease, thus providing a rationale for additional trials of LY2062430.

"Results from this Phase II study are promising, and we are pleased to announce our intention to commence a Phase III pivotal study of LY2062430 beginning in 2009," said Steven M. Paul, M.D., Executive Vice President, Science and Technology, President of Lilly Research Laboratories. "Additionally we are currently enrolling patients into the Phase III study called IDENTITY, which examines treatment with LY450139, an investigational gamma secretase inhibitor believed to slow the rate of formation of amyloid beta, potentially slowing disease progression. These two neuroscience pipeline candidates represent potentially important advances in the effort to slow the progression of this fatal disease, and demonstrate our longstanding commitment to developing treatments for devastating brain illnesses."

About Alzheimer's Disease

Alzheimer's disease is a progressive neurodegenerative condition that is the most common cause of dementia in patients over 65 years of age. Estimates show that 6-8 percent of people older than age 65 are affected by Alzheimer's disease(1), totaling approximately 5 million people in the United States alone(2). Every 72 seconds, an American is developing Alzheimer's disease(3), and it is the se
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... , July 24, 2014 LSI Medience ... an Agreement with Kineticos, a Raleigh-Durham, ... Kineticos will support LSI Medience in identifying opportunities ... to demonstrate utility in clinical trials. ... utility in diagnosis of sepsis, prognosis of septic ...
(Date:7/24/2014)...  The American Association for Homecare (AAHomecare) yesterday ... help address audit issues in the HME industry ... the information technology lead in shaping its HME ... billing and business management solutions for nearly 3,000 ... support this important initiative on behalf of all ...
(Date:7/24/2014)... , July 24, 2014 Decision Resources Group ... the EU5 countries ( France , ... Spain and the ... of the first once-daily long-acting beta2 agonist/inhaled corticosteroid (LABA/ICS) ... uptake of Relvar as a first-line LABA/ICS FDC in ...
Breaking Medicine Technology:LSI Medience Corporation and Kineticos Sign Agreement Related to the Presepsin Biomarker in Sepsis Management and Treatment 2Brightree Joins AAHomecare as Corporate Partner and IT Lead on HME Audit Key 2Surveyed EU5 Pulmonologists Expect that Relvar, the First Once-Daily LABA/ICS FDC, Will Experience Healthy Uptake in Asthma 2Surveyed EU5 Pulmonologists Expect that Relvar, the First Once-Daily LABA/ICS FDC, Will Experience Healthy Uptake in Asthma 3
... Calif., Nov. 17 Poniard Pharmaceuticals, Inc. (Nasdaq: ... randomized, controlled Phase 2 trial of picoplatin in patients ... indicated that picoplatin, given once every four weeks in ... has comparable efficacy to oxaliplatin, given in combination with ...
... , LAKE ZURICH, Ill., Nov. 17 ... improving blood collection, separation, safety and availability, announced today ... the Verax Platelet PGD® test as a quality control ... platelets prior to transfusion. Fenwal is the exclusive ...
Cached Medicine Technology:Poniard Pharmaceuticals Announces Updated Positive Clinical Data from Phase 2 Trial of Picoplatin in Colorectal Cancer and New Phase 1 Cardiac Safety Trial Results 2Poniard Pharmaceuticals Announces Updated Positive Clinical Data from Phase 2 Trial of Picoplatin in Colorectal Cancer and New Phase 1 Cardiac Safety Trial Results 3Poniard Pharmaceuticals Announces Updated Positive Clinical Data from Phase 2 Trial of Picoplatin in Colorectal Cancer and New Phase 1 Cardiac Safety Trial Results 4Poniard Pharmaceuticals Announces Updated Positive Clinical Data from Phase 2 Trial of Picoplatin in Colorectal Cancer and New Phase 1 Cardiac Safety Trial Results 5FDA Clears the First Rapid Test to Detect Bacteria in Pooled Platelets 2FDA Clears the First Rapid Test to Detect Bacteria in Pooled Platelets 3FDA Clears the First Rapid Test to Detect Bacteria in Pooled Platelets 4
(Date:7/24/2014)... 24, 2014 Just as fitness and ... consider their own financial and marketing strength to be ... campaigns to the next level by using the most ... IVR, Voice Broadcast, Call Tracking and SMS texting ... rate, text messages are quickly become integral in marketing ...
(Date:7/24/2014)... CarePoint Health is proud to ... oncology, Dr. Hitendra Upadhyaya, has joined our network, ... Upadhyaya to the community. Hundreds of highly skilled ... a comprehensive network of top doctors and practices ... specialties. This latest acquisition represents CarePoint Health’s commitment ...
(Date:7/24/2014)... of Medicine researchers may have found a way to ... that pre-treatment of neurons with the anti-aging protein Klotho ... toxic amyloid protein and glutamate. These findings currently appear ... , Alzheimer,s disease is the most frequent age-related dementia ... age 65 and older and more than 40 percent ...
(Date:7/24/2014)... -- Drinking caffeine may worsen the hot flashes and ... they go through menopause, new survey data suggests. ... limiting caffeine intake may be useful for those postmenopausal ... said researcher Dr. Stephanie Faubion, director of the Women,s ... But caffeine -- a stimulant found in coffee ...
(Date:7/24/2014)... Bonheur Children,s Hospital and the University of Tennessee Health ... a new drug shown to safely reduce the viral ... infected with respiratory syncytial virus (RSV). RSV is the ... young children in the United States and worldwide. ... Disease Specialist John DeVincenzo, MD. DeVincenzo,s Le Bonheur lab ...
Breaking Medicine News(10 mins):Health News:Pump Up Your Gym’s Marketing Muscles with Mobile Marketing: CallFire's Health & Fitness Webinar Week – July 28th to August 1st 2Health News:Pump Up Your Gym’s Marketing Muscles with Mobile Marketing: CallFire's Health & Fitness Webinar Week – July 28th to August 1st 3Health News:Dr. Upadhyaya Joins CarePoint Health Medical Group 2Health News:BU researchers discover that Klotho is neuroprotective against Alzheimer's disease 2Health News:Is Coffee Aggravating Your Hot Flashes? 2Health News:RSV research breakthrough to help infected children 2
... Studies/Tests; Cover-up Health Hazards on Illinois Beaches ... Beach Visitors, Asbestos Safety Tips Published, CHICAGO, ... send, the media and public are advised to use ... Illinois Dunesland Preservation,Society asked nationally recognized asbestos safety risk ...
... & Amy Philo*, SAN DIEGO, May 23 ... Day, May 10, 1998, Sharon Alley stabbed her ... her. Months before, Alley,was prescribed Paxil, became psychotic, ... her skull., Postpartum Support International (PSI) founder ...
... Two-dozen members,of the Army,s 2nd Battalion, 113th ... LaserVision, getting ready for their upcoming,deployment in Iraq. ... were,undergoing a Lasik procedure that allows them to ... http://www.newscom.com/cgi-bin/prnh/20080523/NYF043 ), Drs. Joseph and Jeffery ...
... into Chengdu, STAMFORD, Conn., May 23 The ... private organizations left,Kansas City today, and AmeriCares medicines and ... is proud to play an instrumental,role in delivering critical ... many years for the people, infrastructure and landscape,of China ...
... 2008 A recent study shows that pre-operative assessments of ... early diagnosis and successful treatment of lymphedema. , The ... and the National Institutes of Health (NIH) and in ... University, was published in the journal, Cancer (April 25, ...
... COMMIT LOZENGE CAN HELP REVERSE MENTAL ACUITY DEFICITS ... for Interview to Address FAA,Ruling on Smoking Cessation ... by the Federal Aviation,Administration (FAA) that it has ... of safe medications for pilots and air-traffic,controllers, it,s ...
Cached Medicine News:Health News:UPDATED: Deadly Asbestos Fibers Found on Chicago's Oak Street Beach 2Health News:UPDATED: Deadly Asbestos Fibers Found on Chicago's Oak Street Beach 3Health News:The MOTHERS Act: Thalidomide Revisited? 2Health News:The MOTHERS Act: Thalidomide Revisited? 3Health News:The MOTHERS Act: Thalidomide Revisited? 4Health News:Soldiers Receive Free Memorial Day Lasik Surgery Before Going to Iraq 2Health News:AmeriCares Ships Medicines and Medical Supplies to Earthquake Victims in China 2Health News:New study shows positive role physical therapists play in lymphedema diagnois and treatment 2Health News:MultiVu Video Feed: FREE NICOTINE REPLACEMENT THERAPY (NRT) TO BE OFFERED TO REGISTERED PILOTS INTERESTED IN QUITTING RELIEF IN LIGHT OF RECENT FAA RULINGS 2
... The THERMOstar is a high performance temperature ... microplates. Temperature, shaking speed and incubation time ... the status parameters are displayed on the ... above and below the microplates provide uniform ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
Minimal M9 Broth...
An agent used for making solid microbiological media....
Medicine Products: