Navigation Links
Phase I Research of Extended-Release Topiramate Shows Less Fluctuation in Plasma Levels
Date:4/11/2011

Extended-Release Formulation of Topiramate) and its Lack of Food-Effect." Authors: Lawrence J. Lambrecht, Wesley M. Todd, Mark B. Halvorsen.

The studies that are the subjects of these posters have been conducted by Upsher-Smith to characterize the pharmacokinetic profile of USL255.  The first poster presented data from numerous internally developed topiramate ER formulations.  The objective of the research presented was to identify a once daily ER formulation with a lower maximum plasma concentration, a higher trough concentration, and an equivalent extent of exposure as compared to IR topiramate.  The PK data from the experimental formulations were compared to IR topiramate, after single doses and/or at simulated steady-state.  Results have aided USL researchers in the formulation selection for USL255.

In another study and second poster presentation, the effect of food on the bioavailability of USL255 was assessed.  In this Phase I, randomized, single-dose, crossover study, 36 healthy subjects received three different treatments (200 mg of USL255 under fasting conditions; 200 mg of USL255 with a high fat meal; or 2 doses of 100 mg IR topiramate dosed 12 hours apart).  Based on PK measurements and using standard bioequivalence criteria, the authors determined that the overall extent of absorption of USL255 was not affected by food. However, the presence of food was associated with a delay in the time to maximal plasma concentration of topiramate, a finding that was deemed consistent with the food effect on IR topiramate pharmacokinetics.  

The second poster also compared two 100 mg doses of IR topiramate (administered 12 hours apart) and a single 200 mg dose of USL255 for pharmacokinetic equivalence, using standard bioequivalence criteria.  The authors reported that administration of 200 mg of USL255 in healthy volunteers provided equivalent topiramate exposure as compared with t
'/>"/>

SOURCE Upsher-Smith Laboratories
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. QNEXA® Phase 3 Data in The Lancet Show Significant Weight Loss and Broad Improvements in Co-Morbidities
2. Update on Phase II/III Clinical Trial of Investigational Staphylococcus aureus Vaccine, V710
3. Regeneron and Bayer Announce Start of Phase 3 Clinical Program in Diabetic Macular Edema
4. Columbia Laboratories and Watson Announce Publication of Positive Phase III PROCHIEVE® Vaginal Progesterone Gel Study Results
5. Jennerex and Transgene Announce Presentation of Phase 1 Data Demonstrating that JX-594 Administration Targets Tumor Vasculature
6. BioDelivery Sciences Announces Completion of Recruitment in BEMA Buprenorphine Phase 3 Chronic Pain Study
7. Regado Biosciences, Inc. Presents Results of the RADAR Phase 2b Clinical Trial of its REG1 Anticoagulation System
8. Positive Phase 2 Results Reported with Boehringer Ingelheims Investigational HCV Protease Inhibitor in Both Previously Treated and Untreated Patients
9. Omeros Reports Outcome of Phase 3 Trials of OMS103HP
10. Conatus Pharmaceuticals Presents Results From a Phase 2 Clinical Trial of CTS-1027 in HCV Genotype 1 Null-Responders
11. Intercept Pharmaceuticals Announces Positive Phase II Results for Obeticholic Acid (INT-747) as Monotherapy in Primary Biliary Cirrhosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Texas , Sept. 2, 2014  XBiotech ... III study being conducted in the US for ... True Human™ monoclonal antibody therapy, is being evaluated ... further complicated with cachexia. The primary endpoint of ... Xilonix treated patients to a control population provided ...
(Date:9/2/2014)... 2014   Santa Clara dentist , Dr. ... for Invisalign. Invisalign is an orthodontic system that uses ... often the orthodontic treatment of choice for older teens ... it. For a limited time, patients can try Invisalign ... the usual cost. This offer cannot be combined, and ...
(Date:9/2/2014)... , September 2, 2014 ... CONGRESS 2014 provide insight into treatment and outcomes ... clinical practice --   Data from ... Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF), an innovative, ... prevention strategies for atrial fibrillation (AF) patients remain ...
Breaking Medicine Technology:XBiotech Halts Study, Reports Positive Phase III Results with Antibody Therapy for Cancer 2Santa Clara Cosmetic Dentist, Dr. Alan Frame, is Now Offering a Special on Invisalign 2Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 2Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 3Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 4Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 5Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 6Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 7Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 8Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 9
... DIEGO, May 31, 2012 Halozyme Therapeutics, Inc. (NASDAQ: ... Jefferies 2012 Global Healthcare Conference in New York on ... PT . Kurt Gustafson, Chief Financial Officer, Halozyme ... http://photos.prnewswire.com/prnh/20100302/LA63139LOGO ) The presentation will ...
... American Pharmacists Association (APhA), a DC-based, non-profit professional ... announced that on Monday evening, May 28, 2012, ... and defaced by an unknown individual or group.  ... APhA considers any attack on its ...
Cached Medicine Technology:Halozyme Therapeutics to Present at the Jefferies 2012 Global Healthcare Conference 2
(Date:9/3/2014)... Job seekers who are interested in expanding their ... do both on iHire. By incorporating MOOCtracks into the ... investigating employment and educational opportunities in the same place. ... skills gaps and challenging the landscape of education by ... and mortar universities. To make it easier for their ...
(Date:9/3/2014)... Morris Psychological Group , ... for depression on October 9, 2014 from 4:30-8:30 ... than 1,000 organizations nationwide will be hosting National ... military installations. After completing a screening, participants will ... that can offer further evaluation and treatment if ...
(Date:9/3/2014)... (PRWEB) September 03, 2014 Joulebody, the ... 20 day custom healthy detox and weight-loss program ... Why?,     Because it’s good for ... clean-out their body. ,     Because using an elimination ... the countless testimonials of clients letting go of caffeine, ...
(Date:9/2/2014)... September 03, 2014 Autumn is ... wants to celebrate the new season with worldwide ... research and announced that Hostgator ( http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts ), ... suppliers of 2014. , Since 2002 HostGator ... provider, and the company’s reputation for reliability remains ...
(Date:9/2/2014)... The symptoms of dry eye disease include the sensation ... burning and visual disturbance. The causes are poorly understood., ... aged 20 to 87 (average age 57) from the ... Thomas, Hospital in London., This cohort is widely regarded ... been used to look at a wide range of ...
Breaking Medicine News(10 mins):Health News:iHire Announces Partnership with MOOCtracks 2Health News:Screenings for Depression by Morris Psychological Group, October 9, 2014 from 4:30 to 8:30pm, Rockaway Townsquare Mall (Macy’s Court) 2Health News:Joulebody Launches a Besoke 20-Day Healthy Lifestyle Program 2Health News:Joulebody Launches a Besoke 20-Day Healthy Lifestyle Program 3Health News:Joulebody Launches a Besoke 20-Day Healthy Lifestyle Program 4Health News:Top10BestSEOHosting.com Celebrates The Coming Of Autumn And Release Reseller Hosting Suppliers Of 2014 2Health News:Around 1 in 10 UK women has dry eye disease, requiring artificial tears 2
... at understanding the influences of paternity on the brain, ... of their close// resemblance with humans. Tiny monkeys called ... valuable insight into how fatherhood can actually ... found that there were structural changes in the brain ...
... increasing the time that kids spend in exercise will not ... weight. //Economist John Cawley of Cornell University and colleagues found ... of students taking part in physical education decreased from 42% ... examined data on 37,000 teens in grades nine through 12. ...
... first trimester could be associated with cardiac abnormalities in ... septal defects, Journal Birth Defects Research Part B, Trimester, ... who take non-steroidal anti-inflammatory drugs (NSAIDs) early in their ... babies with congenital defects. ,The findings of ...
... attention now a days experts have began to ponder as ... //for their own good. ,There are now a ... health groups, like the World Health Organization, the U.S. Centers ... Pediatrics as to if baby fat, which is usually a ...
... mosquito-borne encephalitis B in China, the Beijing News said on ... already killed by the disease. ,In central Henan ... and 40 of them have died so far. These infections ... months of 2006. But the newspaper did not explain why ...
... issue of the Journal, Vascular Surgery, researchers at the University ... put people younger than 60 more at risk of premature ... the study done on nearly 2,500 people younger than 60 ... ,Peripheral vascular disease is a narrowing of blood vessels ...
Cached Medicine News:Health News:NSAIDs In First trimester Linked To Congenital Anomalies In Babies 2Health News:Chubbiness In Babies Might Not Be A Cute Sign 2
Utrata-like fine angled tips with gently curved shaft for performing capsulorhexis through tunnel incisions. Dull finish. Flat handle....
McPherson handle. 45 degree angled shafts. Manufactured in titanium....
This cross action forcep has delicate tips for grasping the capsule. The forcep has an iris stop to prevent inadvertent grasping of the iris....
Similar in construction to the E2002 Utrata Capsulorhexis Forceps with jaw set to open only 3 mm. Flat handle with dull finish....
Medicine Products: