Navigation Links
Phase I Research of Extended-Release Topiramate Shows Less Fluctuation in Plasma Levels
Date:4/11/2011

MAPLE GROVE, Minn., April 11, 2011 /PRNewswire/ -- Upsher-Smith Laboratories today announced the presentation of data indicating that once daily administration of USL255, a proprietary extended-release (ER) formulation of the epilepsy medication topiramate, was associated with less fluctuation in topiramate plasma levels compared to immediate-release (IR) topiramate administered twice daily in healthy volunteers.

These data were presented Monday, April 11 at the American Academy of Neurology's (AAN) 2011 Annual Meeting in Honolulu, HI, and marked another milestone in Upsher-Smith's commitment to addressing unmet patient needs in epilepsy and other central nervous system diseases.

USL255 is being developed for the treatment of adults with partial-onset seizures and is the subject of a Phase III clinical trial (PREVAIL). This proprietary extended-release formulation is designed to provide convenient once-daily dosing with reduced fluctuation in topiramate plasma levels versus traditional IR dosage forms.

"Fluctuations in plasma levels with certain antiepileptic drugs have the potential to cause challenges for patients with epilepsy. There is concern that some individuals may experience increased side effects during peak concentrations, or suffer break-through seizures if plasma levels fall too low. We are excited to share this Phase I data about USL255 and its encouraging pharmacokinetic profile with clinicians at AAN," said Mark Halvorsen, Pharm.D., Senior Director, Clinical Development at Upsher-Smith.

Abstracts of the poster presentations can be found online at www.aan.com. Titles and authors are:

  • "Development and Optimization of Extended-Release Formulations of Topiramate." Authors: Lawrence J. Lambrecht, Wesley M. Todd, John A. Carrithers, Mark B. Halvorsen.
  • "Pharmacokinetic Equivalence Between Immediate-Release Topiramate and USL255 (A Novel
    '/>"/>

SOURCE Upsher-Smith Laboratories
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. QNEXA® Phase 3 Data in The Lancet Show Significant Weight Loss and Broad Improvements in Co-Morbidities
2. Update on Phase II/III Clinical Trial of Investigational Staphylococcus aureus Vaccine, V710
3. Regeneron and Bayer Announce Start of Phase 3 Clinical Program in Diabetic Macular Edema
4. Columbia Laboratories and Watson Announce Publication of Positive Phase III PROCHIEVE® Vaginal Progesterone Gel Study Results
5. Jennerex and Transgene Announce Presentation of Phase 1 Data Demonstrating that JX-594 Administration Targets Tumor Vasculature
6. BioDelivery Sciences Announces Completion of Recruitment in BEMA Buprenorphine Phase 3 Chronic Pain Study
7. Regado Biosciences, Inc. Presents Results of the RADAR Phase 2b Clinical Trial of its REG1 Anticoagulation System
8. Positive Phase 2 Results Reported with Boehringer Ingelheims Investigational HCV Protease Inhibitor in Both Previously Treated and Untreated Patients
9. Omeros Reports Outcome of Phase 3 Trials of OMS103HP
10. Conatus Pharmaceuticals Presents Results From a Phase 2 Clinical Trial of CTS-1027 in HCV Genotype 1 Null-Responders
11. Intercept Pharmaceuticals Announces Positive Phase II Results for Obeticholic Acid (INT-747) as Monotherapy in Primary Biliary Cirrhosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)...   Surefire Medical, Inc. today announced ... Surefire Infusion System with an end hole microcatheter.  ... cancer, using the Surefire resulted in statistically significant ... with significantly decreased uptake in normal liver tissue. ... Society of Interventional Radiology (SIR) meeting in ...
(Date:3/3/2015)... , March 3, 2015  UnaliWear announces the ... advanced support for seniors that guards against wandering and ... The new wearable – the Kanega watch ( ... kind to use an easy speech interface rather than ... information without human input. The watch ...
(Date:3/3/2015)... March 3, 2015  Michigan brothers Dominique Larkin , ... arrhythmogenic right ventricular dysplasia, or ARVD, a disease that causes ... death among young athletes. In 2007, doctors discovered ... game. They later tested Dominique and found his "condition was ... 19, 2015 story in The Ann Arbor News , ...
Breaking Medicine Technology:Clinical Trial Comparing the Surefire Infusion Device to an End Hole Catheter Finds Surefire Increases Tumor Uptake and Decreases Non-Target Embolization In Every Patient, Multiple Liver Cancer Types 2UnaliWear's Wearable For Seniors Extends Independence With Advanced Technology 2Younger of 2 Brothers on the SynCardia Total Artificial Heart Gets a Donor Heart Transplant 2Younger of 2 Brothers on the SynCardia Total Artificial Heart Gets a Donor Heart Transplant 3
... , , ... chemistry sets, ham radio, amateur astronomy, and early computing?  Well, now it is ... the Do-It-Yourself Biology (DIYbio) community, working on everything from microbial fuel cells, low-cost ... , , ...
... American Medical Systems® (AMS) (Nasdaq: ... therapies for both male and female pelvic health, today ... the MiniArc® Precise Single-Incision Sling System, a product for ... Precise is the next generation sling in the MiniArc ...
Cached Medicine Technology:Responsible Science for Do-It-Yourself Biologists 2American Medical Systems Announces FDA Clearance for MiniArc(R) Precise Single-Incision Sling 2American Medical Systems Announces FDA Clearance for MiniArc(R) Precise Single-Incision Sling 3
(Date:3/3/2015)... March 03, 2015 Dan E. Chambers, an ... special focus on capital crimes, recently spoke on the radio ... trial. The hosts of the Independent Journal Review radio show ... working first as a prosecutor and now as a criminal ... decisions made in the trial and sentencing of this high-profile ...
(Date:3/3/2015)... 03, 2015 Today the Brain Injury ... of bike, skate, snow, water, and motorcycle helmets, announced ... injury. The partnership kicks off with Nutcase donating $2 ... http://www.nutcasehelmets.com to BIAA during the month of March ... year BIAA leads the nation in observing Brain Injury ...
(Date:3/3/2015)... March 03, 2015 The human augmentation ... the augmentation market. The wearable augmentation sector is predicted ... size in the upcoming years. , The eye-wear ... to a big number of new products launches in ... region, high technological advancements as well as the rising ...
(Date:3/3/2015)... 03, 2015 Dr. Michael ... and chief clinical integration and network development ... this newly established role, Dr. Nochomovitz is ... Healthcare System physician enterprise, its integration within ... Weill Cornell Physicians. , Dr. Nochomovitz brings ...
(Date:3/3/2015)... March 03, 2015 While it is ... primary reason why young Canadian drivers are signing up ... greater value proposition to be enticed. Due to current ... a very stripped-back form. Its full capability is ... where tracking, predictive maintenance, emergency breakdown services are at ...
Breaking Medicine News(10 mins):Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 2Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 3Health News:Brain Injury Association of America Partners with Nutcase Helmets to Raise Awareness About Brain Injury 2Health News:Human Augmentation Market to Pose 43.5% CAGR Through 2020, States MarketsandMarkets in its New Research Study Now Available at MarketPublishers.com 2Health News:Dr. Michael Nochomovitz to Lead Clinical Integration and Network Development for the NewYork-Presbyterian Healthcare System 2Health News:Dr. Michael Nochomovitz to Lead Clinical Integration and Network Development for the NewYork-Presbyterian Healthcare System 3Health News:Dr. Michael Nochomovitz to Lead Clinical Integration and Network Development for the NewYork-Presbyterian Healthcare System 4Health News:TU-Automotive: Wawanesa Insurance to Discuss How UBI Can Produce Happy, Loyal Customers 2
... Rehabilitation Research and Development (JRRD) mainly analyses articles related ... sexuality, chronic pain and prosthetics research. ,Under ... pain associated with spinal cord injury the author of ... cord injury) reported chronic pain. He inquired about their ...
... are said to account for a large portion of ... to assess// this assumption in the Arab world. ... WHO World Mental Health (WMH) Survey Initiative, a nationally ... in Lebanon between September, 2002, and September, 2003, through ...
... School of Veterinary Medicine have established a national ... to humans and animals using medical records of ... Professor of Epidemiology. Larry Glickman of the School ... Pet Hospital, a nationwide chain of veterinary hospitals ...
... Pete Burns, following complaints of "sleep deprivation and exhaustion", has ... ,Burns, who is 46, had been residing at ... expensive pounds 450-a-night. There has been gossip doing the rounds ... the star out of his room for not paying his ...
... study by the New England Research Institutes in collaboration with ... or too little// are at a greater risk of developing ... based on studies done on over 1709 men, in the ... a period of 15 yrs. ,According to the ...
... A novel study conducted by Columbia University Medical ... for use in osteoarthritis, could be effective// in ... Until now, drug treatment with Cox-2 inhibitors or ... patients with chronic shoulder pain. ,Approximately ...
Cached Medicine News:Health News:JRRD Focuses On Issues Such As Spinal Cord Injury and Prosthetics 2Health News:JRRD Focuses On Issues Such As Spinal Cord Injury and Prosthetics 3Health News:A National Survey Revealed That Mental Disorders Are Common In Lebanon 2Health News:Pets As Disease Watchdogs 2Health News:Sodium Hyaluronate Shows Promise In Treatment Of Shoulder Pain 2
Non-mydriatic stereo fundus camera for glaucoma detection at early stage....
Eye Q SuperLite is ideal for color and red-free imaging used in general clinical and optometric casework such as anterior segmenting and diabetic screening....
The Genesis Camera meets the needs of those with specific requirements that cannot be met by a conventional 'chinrest' type camera....
Nidek offers 3-Dx Digital stereo camera to provide a complete and comprehensive digital imaging platform....
Medicine Products: