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Phase 3 Trial of Aflibercept in Second-Line Metastatic Colorectal Cancer to Continue as Planned at Recommendation of Independent Data Monitoring Committee
Date:9/8/2010

F Trap) with common chemotherapy regimens in several types of cancer.  In addition to VELOUR, the program includes two Phase 3 trials and one Phase 2 trial, all of which are fully enrolled:

  • VITAL study: 2nd-line treatment for metastatic non-small cell lung cancer in combination with docetaxel (Phase 3). Complete results are anticipated in the first half of 2011.  
  • VENICE study: 1st-line treatment for hormone-refractory metastatic prostate cancer (mHRPC) in combination with docetaxel and prednisone (Phase 3). An interim analysis is expected to be conducted by an IDMC in mid-2011, with complete results anticipated in 2012.
  • AFFIRM study: 1st-line treatment in mCRC in combination with folinic acid (leucovorin), 5-fluorouracil, and oxaliplatin (FOLFOX) (Phase 2).  Results are anticipated in 2H 2011.

  • About Aflibercept Aflibercept (VEGF Trap) is an anti-angiogenesis inhibitor with a unique mechanism of action.  This fusion protein binds all forms of Vascular Endothelial Growth Factor-A (VEGF-A), as well as VEGF-B and placental growth factor (PIGF), additional angiogenic growth factors that appear to play a role in tumor angiogenesis and inflammation. Aflibercept has been shown to bind VEGF-A, VEGF-B, and PlGF with higher affinity than their natural receptors.

    About Colorectal Cancer Worldwide, colorectal cancer is the third most common cancer in men and the second in women; accounting for about 8% of all cancer deaths, making it the fourth most common cause of death from cancer.  Colorectal cancer disproportionately affects people over age 65.  FOLFIRI (5-fluorouracil, leucovorin, and irinotecan) is considered a standard backbone of second-line treatment in patients with advanced metastatic colorectal cancer.

    About sanofi-aventis OncologySanofi-aventis Oncology is targeting cancer on all fronts in an effort to address unmet medical needs for a broad range of patie
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    SOURCE Regeneron Pharmaceuticals, Inc.
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