Navigation Links
Phase 3 Trial Shows Denosumab Delayed Skeletal Related Events in Advanced Cancer Patients With Bone Metastases
Date:9/21/2009

re reduced or delayed. The primary and secondary endpoints of the denosumab bone metastases studies use a composite endpoint of four SREs - fracture, the need for radiation to bone, the need for bone surgery, and spinal cord compression - to measure the effectiveness of denosumab versus Zometa.

The primary endpoint was to evaluate if denosumab is non-inferior to Zometa with respect to the first on-study SRE in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma and bone metastases. Secondary endpoints were to evaluate if denosumab is superior to Zometa with respect to the first on-study SRE, as well as first-and-subsequent on-study SREs, and to assess the safety and tolerability of denosumab compared with Zometa.

About Denosumab and Amgen's Research in Bone Biology

Denosumab is the first fully human monoclonal antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 patients in trials across indications worldwide, the denosumab development program is the largest ever initiated by Amgen. This broad and deep development program demonstrates Amgen's commitment to researching and delivering pioneering medicines to patients with unmet medical needs. Amgen is studying denosumab in numerous tumor types across the spectrum of cancer-induced bone disease. Over 11,000 patients have been enrolled in the denosumab oncology clinical trials, testing the drug for the reduction of SREs in breast cancer patients, for the amelioration of treatment-induced bone loss in patients with breast or prostate cancers, for the prevention of SREs due to the spread of cancer to the bone in patients with multiple myeloma or those suffering from a variety of solid tumors, and for its potential to delay bone metastases in prostate cancer.

Bone Metastases: Impact and Pre
'/>"/>

SOURCE Amgen
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... NOWDiagnostics Inc., based in Springdale, Ark. ... Canada , a move that brings the ... people have greater access to information concerning their health. ... unique blood-based rapid tests that allow health care providers ... of ailments and diseases. ZBx Corporation, a ...
(Date:9/1/2015)... Sept. 1, 2015 Emerus Holdings, a ... emergent, inpatient and diagnostic care in partnership with ... a definitive agreement to receive a strategic investment ... a leading health care investment firm. ... patient-centric acute episodic and ambulatory clinical services to ...
(Date:9/1/2015)... , Sept. 1, 2015 Sleep ... sleep therapy, and HGE Health Care Solutions, a ... announced today a comprehensive sleep management and cost ... (OSA). OSA is a chronic medical ... sleep and may increase a patient,s risk for ...
Breaking Medicine Technology:NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 2Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 3Sleep Specialists, LLC and HGE Health Care Solutions Announce Comprehensive Sleep Program 2
... 2012 /PRNewswire-Asia/ -- As the whole world battles against cancer, ... a great improvement. Cancer is still the number one cause ... patients have, in recent times, managed to survive for more ... are available in Korea. The Korean government recently ...
... TeDan Surgical Innovations , industry leader in surgical ... Series MIS Anterior Hip Retractor System . TeDan Surgical,s ... arms with attachable retractors, enabling surgeons to perform the ... assistant. Dr. Lawrence Menendez and Dr. ...
Cached Medicine Technology:Survival Rate of Cancer Patients in Korea Ranked in the Top in the World 2New Minimally Invasive Hip Retractor Revolutionizes Anterior Hip Replacement Procedures 2
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... Horizon Blue ... the 50 Best Companies for Latinas in the LATINA Style 50 Report that recognizes ... , For 2015, Horizon BCBSNJ climbs from number 24 to 21 ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... and collaboration, announces Splashtop Business for Remote Support , a solution optimized ... solution. Unhappy with the escalating renewal prices and inadequate customer services of ...
(Date:9/1/2015)... ... September 01, 2015 , ... The ... Information Management has been granted continued accreditation based on a successfully completed ... “Achieving and maintaining this accreditation takes the involvement and dedication of each ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... announced the release of version 5.2 of the FirstSpirit Content Management System with ... initiative. With the new version of FirstSpirit, companies will be well on their ...
(Date:9/1/2015)... ... , ... Two of Washington D.C.’s most respected chefs are using their global ... Recently named “the next big thing” in the culinary world by Elle Spain, award-winning ... behind food and reclaiming culinary traditions on the brink of extinction. According to Amy ...
Breaking Medicine News(10 mins):Health News:Horizon Blue Cross Blue Shield of New Jersey Named One of the 50 Best Companies for Latinas by Latina Style Magazine 2Health News:Horizon Blue Cross Blue Shield of New Jersey Named One of the 50 Best Companies for Latinas by Latina Style Magazine 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 4Health News:Edge Information Management Granted Continued NAPBS Accreditation 2Health News:Edge Information Management Granted Continued NAPBS Accreditation 3Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 4
... The San Diego Supercomputer Center (SDSC) at the University ... (Leadership in Energy & Environmental Design) Gold certification for ... certification was granted in the ,Existing Buildings Operations & ... a non-profit organization promoting efficient and energy-saving ,green, buildings. ...
... -- Weight loss and malnutrition are among the medical ... hospital stays for older adults with hip fractures, a ... occur each year in the United States, often resulting ... disability, and admission to a nursing home. This ...
... skinned knees on the playground and coaxing their children ... their offspring,s physical health in middle age. In ... Science , Brandeis psychologist Margie Lachman with Gregory Miller ... the University of California, Los Angeles reveal that while ...
... preventing colon cancer be as simple as developing a taste ... study, scientists showed that human colon cancer cells die when ... present in one cup of this brew, which has long ... "The caffeine derivatives in mate tea not only induced death ...
... Jan. 23, 2012 The March of Dimes, along with ... birth prevention an opportunity to learn from each other and ... under 10 percent and give more babies a healthy start. ... speaker for the Prematurity Prevention Symposium. The symposium will was ...
... maps has revealed in unprecedented detail the current global pattern ... changed over a number of years. In a study ... of researchers from the Malaria Atlas Project (MAP), funded mainly ... effort to assemble all available data worldwide on the risk ...
Cached Medicine News:Health News:SDSC's East Building receives LEED Gold Certification 2Health News:Hip Fracture Patients Often Have Other Health Problems 2Health News:Nurturing mothers rear physically healthier adults 2Health News:Nurturing mothers rear physically healthier adults 3Health News:Compounds in mate tea induce death in colon cancer cells 2Health News:March of Dimes launches Prematurity Prevention Network 2Health News:March of Dimes launches Prematurity Prevention Network 3Health News:New malaria maps to guide battle against the disease 2
Ergotec Vetriretinal Instrument System. 2 mm pointed tips with 0.6 mm platform. 20 gauge shaft tapers to 23 gauge....
Angled shafts with 12 mm scaled jaws. 1 mm teeth on one jaw fit into holes on the other jaw. Slide lock and serrated handle with polished finish. Left. Most popular size or model....
Angled shafts with 9 mm scaled jaws. 1 mm teeth on one jaw fit into holes on the other jaw. Slide lock and serrated handle with polished finish. Left....
Angled 13.5 mm adjustable blades. Teeth in lower jaws fit into holes in upper jaws. Grooves in lower jaw for passage of suture needles. Round knurled handle with polished finish....
Medicine Products: