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Phase 3 Study of VX-770 Shows Marked Improvement in Lung Function Among People with Cystic Fibrosis with G551D Mutation
Date:2/23/2011

In addition, the CF Foundation is expanding its medical research program by $100 million over the next five years to focus on developing therapies, known as CFTR modulators, which address the underlying defect.

Vertex's VX-770 Phase 3 program involves three different clinical trials, including the trial for people age 12 and up with the G551D mutation described above. In addition, a VX-770 trial of children ages 6 to 11 with the G551D mutation is ongoing and results are expected in mid-2011. The company also announced results for a trial evaluating VX-770 in patients with two copies of the Delta F508 mutation. Safety was the study's primary focus, and adverse events were similar between the VX-770 and placebo groups in the study. Patients did not show a clinically meaningful improvement in lung function, although sweat chloride improved by a small amount.

Results from all three studies will be part of the drug application Vertex will submit to the FDA.

About the Cystic Fibrosis Foundation

The Cystic Fibrosis Foundation is the world's leader in the search for a cure for cystic fibrosis. The Foundation funds more CF research than any other organization, and nearly every CF drug available today was made possible because of Foundation support. Based in Bethesda, Md., the Foundation also supports and accredits a national care center network that has been recognized by the National Institutes of Health as a model of care for a chronic disease. The CF Foundation is a donor-supported nonprofit organization. For more information, go to www.cff.org.


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SOURCE Cystic Fibrosis Foundation
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