Navigation Links
Phase 3 Data Show New Anti-TNF, Golimumab, Significantly Improved Arthritis, Skin and Nail Manifestations in Patients with Psoriatic Arthritis
Date:11/7/2007

golimumab 100 mg, respectively, achieved PASI 75 at week 14, compared with 3 percent of patients receiving placebo (P < 0.001). At week 24, PASI 75 responses improved to 56 percent (golimumab 50 mg) and 66 percent (golimumab 100 mg), compared with 1 percent of placebo patients (P < 0.001). In additional analyses, patients receiving golimumab 50 mg and golimumab 100 also experienced improvements in nail psoriasis as measured by NAPSI and these improvements were sustained over time.

"These Phase 3 data show that once monthly subcutaneous administrations of golimumab 50 mg and golimumab 100 mg significantly improved articular and psoriatic manifestations in patients with psoriatic arthritis," said Jerome A. Boscia, MD, senior vice president, Clinical Research and Development, Centocor, Inc. "We are encouraged by these results and believe golimumab holds great promise as a new anti-TNF-alpha therapy for physicians and patients in need of additional therapeutic options."

Disease Activity and Physical Function Improvements

The majority of golimumab-treated patients in the study were classified as good or moderate responders as measured by the Disease Activity Score 28 (DAS28), which measures tender and swollen joints and overall disease activity including measurement of serum C-reactive protein (CRP) levels. After 14 weeks of treatment, 66 percent of patients receiving golimumab 50 mg were DAS28 responders, as were 67 percent of patients receiving the 100 mg dose, compared with 24 percent of patients receiving placebo (P < 0.001). At week 24, 64 percent and 78 percent of patients receiving golimumab 50 mg and 100 mg, respectively, were DAS28 responders, compared with 24 percent of patients receiving placebo (P < 0.001).

Patients receiving golimumab in the study also experienced significant improvements in physical function, as measured by the Health Assessment Questionnaire (HAQ). At week 14, patients receiving golimumab 50 mg experienced a mean i
'/>"/>

SOURCE Centocor Inc.
Copyright©2007 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
3. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
4. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
5. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
10. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
11. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... , May 18, 2013 Faruqi ... firm, is investigating potential securities fraud at AVEO ... (Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO ) ... and its executives violated federal securities laws by ... Company,s Phase III drug trials for Tivopath (tivozanib) ...
(Date:5/17/2013)... SAN DIEGO , May 17, 2013 /PRNewswire/ ... today that its Fast-Track Advanced Technology Small Business ... National Institute of Allergy and Infectious Diseases (NIAID), ... (NIH), supporting the development of novel human antibody ... S. aureus or Staph) infections, including methicillin-resistant ...
(Date:5/17/2013)... 17, 2013  Sony Biotechnology Inc. ("Sony") today announced the ... and 130um sorting chip.  Sony will also be exhibiting its ... SH800 Cell Sorter, the EC800 flow cytometer, and new SP6800 ... 2013, which will be held at the San ... California , from May 20 - 22.  ...
Breaking Medicine Technology:Faruqi & Faruqi, LLP Encourages Investors Who Suffered Losses In Excess Of $100,000 Investing In AVEO Pharmaceuticals, Inc. To Contact The Firm 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 3Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 4Sony Delivers New Technology for Science to CYTO 2013 2
... , DURHAM, N.C., Sept. 8 ... formally notified Vatea Fund of the company,s achievement of a milestone ... September 1, 2009. The milestone is a Clinical Trial for Oxycyte ... With the achievement of the milestone, the agreement calls for ...
... BOZEMAN, Mont., Sept 8 LigoCyte Pharmaceuticals, Inc. ... clinical trial of its norovirus vaccine. The Phase I/II ... nasally-delivered, dry powder vaccine in healthy adults. The study will ... by including a live virus challenge of subjects that have ...
Cached Medicine Technology:LigoCyte Pharmaceuticals Initiates a Randomized, Double Blind, Placebo Controlled Norovirus Vaccine Study Including Live Virus Challenge 2LigoCyte Pharmaceuticals Initiates a Randomized, Double Blind, Placebo Controlled Norovirus Vaccine Study Including Live Virus Challenge 3
(Date:5/20/2013)... 2013 The nationwide law firm of Bernstein ... magnetic resonance imaging (MRI) can be used to predict ... patients are experiencing symptoms. According to an article published ... Joint Surgery, MRI detected synovitis (tissue damage) in 68% of ... to mechanical causes, the detection rate was 75%, while MRIs ...
(Date:5/20/2013)... whose mother lived near heavy traffic while pregnant faces ... before the age of 3, a new study suggests. ... of mothers and infants from eastern Massachusetts. All the ... of pregnancy at some point between 1999 and 2002. ... 100 meters (about 110 yards) from a major roadway, ...
(Date:5/20/2013)... is it about toothpaste that transforms the sweet flavor ... solution to that mysterious sensory phenomenon in colorful, ... American Chemical Society,s award-winning Bytesize Science video ... the world,s largest scientific society, explains that the mainstay ... sulfate, or SLS for short. When you brush your ...
(Date:5/20/2013)... (PRWEB) May 20, 2013 Join Seva Foundation ... concert at the Palace of Fine Arts Theater ... Uttal , C.C. White and Shimshai, with host Wavy Gravy. ... the world. , Reserved seats are $40 & ... with the artists and a front row seat at the ...
(Date:5/20/2013)... 20, 2013 Cliff Lake Dental Care is pleased ... patient schedules when visiting the dentist office . The change ... life schedule. , Here are the new office hours: Mondays- 8 ... – 8 a.m. to 1 p.m. and 2-5 p.m., Thursdays 7 ... office will be open to take appointments only. Cliff Lake Dental ...
Breaking Medicine News(10 mins):Health News:Metal-on-Metal Hip Replacement Lawyers Note New Study Finding MRIs Can Be Used to Predict Metal-on-Metal Hip Implant Failure 2Health News:Metal-on-Metal Hip Replacement Lawyers Note New Study Finding MRIs Can Be Used to Predict Metal-on-Metal Hip Implant Failure 3Health News:Metal-on-Metal Hip Replacement Lawyers Note New Study Finding MRIs Can Be Used to Predict Metal-on-Metal Hip Implant Failure 4Health News:Living Near Major Roadways in Pregnancy Tied to Respiratory Woes in Children 2Health News:Memorial Day Kirtan Concert Palace of Fine Arts Theater in San Francisco Featuring: Snatam Kaur, Jai Uttal, C.C. White & Shimshai with host Wavy Gravy,May 27th 7:00 PM 2Health News:Cliff Lake Dental Care Announces Office Hours Change 2
... student committed suicide by shooting herself at her south ... alone at home in the upmarket Hauz Khas area ... official. She is the daughter of Vijendra Rai, additional ... that Mrinalini had used her father's licensed gun. ...
... a respected osteopathic physician and best known founder ... website, http://www.mercola.com, has revealed the// secrets of some ... Splenda, NutraSweet and the FDA May Be Hazardous ... some artificial sweetener industry. You can watch Dr. ...
... NHS Trust at Scarborough and North East Yorkshire which ... Whitby, Ryedale and Bridlington// is presently facing a dilemma. ... an attempt to overcome the severe financial crunch has ... deliveries at home. ,The Trust which is ...
... high-profile detainee at Guantanamo Bay, Cuba, the US government ... could "cause extremely grave damage", the Washington Post reported ... prisons must not be allowed to talk about the ... lawyers, the Post reported.,A lawyer at a firm that ...
... an individual's immune system to control HIV infection appears ... immune-system molecules// called HLA Class I that have been ... protein those molecules display to the T lymphocytes that ... November issue of PLOS Medicine, researchers from the Partners ...
... An instant fine will be levied to patients who behave ... ?80 fines- a trailblazing move by an NHS hospital to ... , ,The Royal Bolton hospital in Greater Manchester ... violent behavior in hospitals. This move is after much deliberation ...
Cached Medicine News:Health News:Genes determine the capacity to fight HIV in early stages 2Health News:Genes determine the capacity to fight HIV in early stages 3
Used for drainage and navigation of a tortuous ureter. The tapered tip eases placement as there are no edges to interfere with the ureteral orifice. Supplied sterile in peel-open packages. Intended f...
Used for the retrieval of stones, stents, or other objects in the urinary tract under direct vision. Retrieval Forceps are designed for use through rigid or flexible endoscopes. Supplied sterile in p...
... Angle Cutting Electrode is a monopolar ... general purpose monopolar electrosurgical generator and ... ACMI rigid, semi-rigid, or flexible ureteroscope ... working channel larger than 3 Fr. ...
... The ACMI USA Series ACN-2 Flexible CystoNephroscope ... It is ideal for office practice. The ... accommodates a full range of operating instruments ... outer diameter, and beveled, UltraGlide covered tip ...
Medicine Products: