Navigation Links
Phase 3 Data Show Intravenous Golimumab Inhibited Radiographic Progression in Patients with Active Rheumatoid Arthritis
Date:11/12/2012

osis and one death, a myocardial infarction secondary to community-acquired pneumonia, were reported in the I.V. golimumab group.  Through week 52, the proportions of infusions and patients with infusion reactions were 0.7 percent and 3.6 percent, respectively, (versus 1.1 percent and 3.5 percent at week 24, respectively).

About GO-FURTHER
The GO-FURTHER trial is a Phase 3, international multicenter, double-blind, placebo-controlled study including 592 adults with RA designed to compare ACR 20 response at week 14 in patients receiving an I.V. golimumab infusion  plus methotrexate compared with patients receiving placebo infusions plus methotrexate. The trial included patients diagnosed with active RA who had at least six tender and six swollen joints and who had been receiving background methotrexate for at least three months. Patients were randomized 2:1 to receive a 30 (+/- 10) minute I.V. infusion of golimumab  2 mg/kg or placebo plus methotrexate at weeks 0, 4, and then every eight weeks.  The primary endpoint of the study was ACR 20 at week 14.  At week 16, patients receiving placebo with less than 10 percent improvement in combined swollen and tender joint counts were entered into early escape to receive I.V. golimumab 2 mg/kg at week 16 and week 20.  All patients receiving placebo crossed over to I.V. golimumab at week 24. Radiographs of the hands and feet were taken at baseline, week 24 (week 16 for early escape participants) and week 52 and were scored using the modified vdHS score.  Week 24 results from the Janssen-sponsored study were presented earlier this year at the 2012 EULAR Annual Congress and also appeared in the Annals of the Rheumatic Diseases.

About Rheumatoid Arthritis 
Rheumatoid Arthr
'/>"/>

SOURCE Janssen Research & Development, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
2. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
3. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
4. Retrospective Study Suggests that Stereotactic Ablative Radiotherapy (SABR) Can be a Viable Option for Treating Early-Stage Lung Cancer in Operable as well as Inoperable Patients; Phase III Randomized Trial Now Under Way
5. Ultragenyx Announces Phase 1 Results of UX001 in Hereditary Inclusion Body Myopathy (HIBM), a Rare Neuromuscular Disease
6. Lexicon Receives Funding for Phase 2 Clinical Trial of LX4211 in Type 1 Diabetes
7. Isis Initiates Phase 2 Study of ISIS-APOCIIIRx in Patients with Hypertriglyceridemia
8. Alder BioPharmaceuticals Inc. Initiates Phase 1 Clinical Study of Antibody Therapeutic Candidate for Treatment of Migraine, ALD403
9. Results Reported for Phase Ib Open-Label Clinical Trial for the Treatment of Depression Using External Trigeminal Nerve Stimulation (eTNS™) - The USB Port to the Brain™
10. Pearl Therapeutics Phase 2b Twice-Daily Dosing Data Suggest Morning and Evening Benefit of PT003 in Patients with COPD
11. Adamas Pharmaceuticals Announces Successful End-of-Phase 2 Meeting with FDA for Arimenda™
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... JERUSALEM , April 27, 2015 ... successfully completed filing of a Pre-Marketing Notification Application (510k) ... its BRH-A2 Wound Management System. BRH Medical expects feedback ... entering the US market with BRH-A2 following FDA pre-market ... Motti Oderberg , CEO for BRH ...
(Date:4/27/2015)... , April 27, 2015 - ... Process Patent by the State Intellectual Property Office of ... Based on Pooling Technology  - A New Treatment ... (CLI)    - About 20% of Elderly Urban ... in Women is Substantially Higher Than in Men. CLI is ...
(Date:4/26/2015)... April 26, 2015  Ikonopedia announced today that ... system have been selected for use by BelleBridge, ... screening and diagnostic examinations. Ikonopedia will showcase its ... of Breast Imaging,s SBI/ACR Breast Imaging Symposium in ... 2015 (SBI Booth #216). BelleBridge is ...
Breaking Medicine Technology:BRH Medical, Ltd., Announces Filing of a Pre-Market Submission with the US Food and Drug Administration (FDA) for the BRH-A2 Tissue Management System 2Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 2Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 4Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 2Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 3Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 4
... of human-animal hybrids to generate stem cells WORCESTER, ... Pink Sheets: ACTC) and its collaborators reported today that ... reprogram adult human cells. The research, which appears online ... Stem Cells (Editor-in-Chief: Sir Ian Wilmut; published by ...
... Men who experience erectile dysfunction between the ages of ... disease than men without dysfunction, according to a new Mayo ... have an 80 percent higher risk of heart disease. "The ... says researcher Jennifer St. Sauver, Ph.D. The study was published ...
Cached Medicine Technology:Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 2Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 3Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 4Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 5Mayo Clinic Study Finds Younger Men With Erectile Dysfunction at Double Risk of Heart Disease 2Mayo Clinic Study Finds Younger Men With Erectile Dysfunction at Double Risk of Heart Disease 3
(Date:4/27/2015)... Attorney Dan Newlin, of the Law Offices ... clients, took that commitment to a whole new level with ... it easier for existing and potential clients to contact the ... and added value to the firm’s services, #Dan covers Central ... has law offices. , “I knew the pound sign (#) ...
(Date:4/27/2015)... 27, 2015 Texas has saved $433 ... drug offenders to providing drug offenders with addiction treatment, ... on April 8th. Several states, including Massachusetts, are considering ... incarceration. Texas has formed community recovery programs to help ... The Council of State Governments WA, ID, NE, ...
(Date:4/27/2015)... 2015 Climate change predictions are largely ... the number of variables used and the availability of ... water researcher Gerald Pollack, PhD, and Climatologist L.DeWayne Cecil, ... Water® radio show, noted three potential weaknesses that could ... of these individuals dispute that Earth’s climate is changing. ...
(Date:4/27/2015)... Winscribe Professional for Windows Phones ... mobile speech productivity technology, which also includes applications ... , Winscribe has supported mobile dictation ... With the latest enhancement, Winscribe Professional for ... interface in the last ten years. The ...
(Date:4/27/2015)... PREVENT Life Safety, America’s premier provider ... with the addition of an account manager in Houston. ... a growing customer base, Curtis Rice, an experienced sales ... Account Manager. Curtis has been added to the team ... the Houston area and beyond. , Curtis ...
Breaking Medicine News(10 mins):Health News:Dan Newlin Hashtags It With #Dan 2Health News:Texas Saves $443 Million Embracing Justice Reinvestment for Drug Charges 2Health News:Texas Saves $443 Million Embracing Justice Reinvestment for Drug Charges 3Health News:Global warming: Computer weather models flawed report Climatologist, Water Researcher on Sharon Kleyne Hour™ radio show 2Health News:Global warming: Computer weather models flawed report Climatologist, Water Researcher on Sharon Kleyne Hour™ radio show 3Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 2Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 3Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 4Health News:PREVENT Life Safety Services Welcomes Curtis Rice as a New Senior Account Manager in Houston, TX 2
... Bangalore, SUNNYVALE, Calif., Jan. 8 Accuray,Incorporated ... the field of radiosurgery,announced today that Healthcare Global ... for its new oncology center in,Bangalore, India. Upon ... first,CyberKnife System in India, expanding treatment access to ...
... N.J., Jan. 8 Jennifer J. Day, Senior Vice,President ... the,addition of Kenneth A. Sylvia as publisher of Current ... healthcare industry who brings to DHM,30 years of experience ... bases we serve," Day said. DHM is a subsidiary ...
... Affairs highlights large employer,s efforts to ... to treatment, PHILADELPHIA, Jan. 8 Removing ... to remain,on recommended therapies according to a new ... Health Affairs. The study, funded, in part,by GlaxoSmithKline ...
... Too Faced ... Cosmetics and FUZE Beverages, NEW YORK, Jan. 8 ... a lip gloss that keeps you both energized,and beautiful. Yes indeed ... lip gloss on the market to "fuse" beauty and fitness,benefits, this ...
... Centers and free coffee ... give blood, DETROIT, Jan. 8 In honor of ... Cross Donors,Employees and Volunteers in Michigan for two weeks in ... all donors,at any of the participating American Red Cross blood ...
... Medicaid spending slowed for first time since its inception ... The new Medicare prescription drug plan was largely responsible ... 2006, which was double the increase in spending from ... 2006, Medicare spending reached $401.3 billion, an increase from ...
Cached Medicine News:Health News:CyberKnife Radiosurgery Expands to India 2Health News:CyberKnife Radiosurgery Expands to India 3Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 2Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 3Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 4Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 5Health News:NEW! Too Faced FUZE Slenderize Guilt Free Gloss 2Health News:Dunkin' Donuts Celebrates the New Year by Supplying Goodies to Michigan's American Red Cross 2Health News:Medicare Drug Plan Fuels Health-Care Spending 2Health News:Medicare Drug Plan Fuels Health-Care Spending 3
Micro instruments designed to provide maximum grasping, resecting capability, and excellent maneuverability for easy access to tight, small joints (wrist, elbow, and ankle).,Features pinless hinge d...
... LactoSorb® No-Profile Screw and Washer ... for multiple soft tissue re-attachments ... No-Profile Screw and washer provides ... a standard screw and washer ...
... The Stryker Inter-Lock™ System ... surgery at the tibial fixation ... backup fixation into one implant. ... and can be used routinely ...
The Stryker Bioabsorbable Wedge Interference Screw is made of Poly-L Lactic Acid (PLLA). The patented wedge design makes it perfect for cruciate reconstruction and is indicated for BTB and soft tissu...
Medicine Products: