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Phase 2b Data Suggest ReVision's Oral Fenretinide (RT-101) Slows Lesion Growth, Preserves Vision and Reduces Incidence of Neovascularization in Geographic Atrophy Patients
Date:10/18/2010

nd induction of angiogenic mediators has been implicated in risk and progression of wet AMD. Fenretinide limits the delivery of retinol to the eye through reduction of serum RBP. This slows the accumulation of retinol-derived toxins in the retina, thereby slowing lesion growth. The anti-inflammatory and anti-angiogenic properties of fenretinide are thought to provide an additional therapeutic benefit against development of wet AMD.

About ReVision Therapeutics

ReVision Therapeutics Inc. is an ophthalmic biopharmaceutical company developing a novel small-molecule drug to slow the progression of the dry form of age-related macular degeneration (AMD) and prevent wet AMD. Fenretinide (RT-101), ReVision's lead drug candidate, showed a positive treatment effect for both slowing lesion growth in dry AMD and reducing the incidence of wet AMD in a Phase 2b clinical trial in patients with geographic atrophy, the most advanced form of dry AMD. The company plans to initiate a pivotal Phase 3 trial after discussion with the FDA. AMD is the leading cause of blindness in the elderly, and there are currently no treatments for the dry form of AMD, which accounts for 90 percent of patients with the disease. Dry AMD gradually destroys sharp, central vision. Most cases of wet AMD are preceded by dry AMD, and the onset of wet AMD can cause rapid blindness. ReVision was founded in 2010 with corporate headquarters in San Diego, California. For more information, visit www.revisiontherapeutics.com

Media Contact
Heidi Chokeir, Ph.D.
Russo Partners, LLC
(858)380-6584
heidi.chokeir@russopartnersllc.com




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SOURCE ReVision Therapeutics Inc.
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