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Phase 2b Data Suggest ReVision's Oral Fenretinide (RT-101) Slows Lesion Growth, Preserves Vision and Reduces Incidence of Neovascularization in Geographic Atrophy Patients
Date:10/18/2010

CHICAGO, Oct. 18 /PRNewswire/ -- ReVision Therapeutics Inc. today announced results from a Phase 2b trial suggesting that fenretinide (RT-101) slows lesion growth and preserves visual acuity in patients with geographic atrophy (GA), the most advanced form of dry age-related macular degeneration (AMD). The data showed that a sustained reduction in retinol binding protein (RBP) levels of 60 percent to 75 percent was predictive of positive treatment response to fenretinide. Patients receiving fenretinide who achieved this RBP reduction threshold experienced a ~49 percent slower rate of lesion growth compared to patients receiving placebo.

Visual acuity was also preserved in patients experiencing a sustained RBP reduction. Additionally, fenretinide reduced the incidence of CNV, the more sight-threatening wet form of AMD, by about 40 percent. Taken together, these results suggest that once-daily oral dosing of fenretinide has the potential to slow progression of dry AMD and prevent the onset of wet AMD in GA patients.

"We are very encouraged because these data demonstrate that fenretinide may improve clinical outcomes for patients with both the dry and wet forms of AMD," said Jason Slakter, M.D., clinical professor of ophthalmology at New York University School of Medicine, who evaluated the lesion image data for the trial and presented the study results yesterday at the Annual Meeting of the American Academy of Ophthalmology. "Additionally, for the first time ever, we may have a biomarker to predict patient response to therapy, as approximately one-third of the patients who achieved a profound and sustained reduction in RBP levels experienced a beneficial treatment effect. I am looking forward to future studies to confirm these results and determine
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SOURCE ReVision Therapeutics Inc.
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