Navigation Links
Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma
Date:1/9/2008

targeting two separate epigenetic pathways simultaneously, the combination of drugs targeting DNA methylation and histone deacetylation can either increase the susceptibility of cancer cells to standard chemotherapy or act as a potent therapeutic regimen in its own right.

About Hodgkin Lymphoma

Hodgkin lymphoma (HL) is a cancer of the lymphatic system that begins in the lymph nodes and progresses to other organs, including the lungs, liver, bone and bone marrow. It is characterized by the presence of Reed-Sternberg cells. Currently, there is no known cause of the disease, but epigenetic alterations including changes in histone acetylation, have been identified. In addition, the Epstein-Barr virus, HIV and familial history are known risk factors. The disease is slightly more prevalent in men than women, and the median age of diagnosis is 38.

About Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma (NHL) are any of a large group of cancers of the immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever, and weight loss. There are many different types of NHL, which can be divided into aggressive (fast-growing) and indolent (slow-growing) types and can be classified as either B-cell or T-cell NHL. B-cell NHLs include Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell NHLs include mycosis fungoides, anaplastic large cell lymphoma, and precursor

T-lymphoblastic lymphoma. Lymphomas related to lymphoproliferative disorders following bone marrow or stem cell transplantation are usually B-cell NHLs. Currently, there is no known cause of the disease, but epigenetic alterations including histone acetylation, have been identified. In addition, the Epstein-Barr virus, HIV, Hepatitis-C and familial history are known risk factors.

The disease is slightly more prevalent in men then women, and i
'/>"/>

SOURCE Pharmion Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Pharmions Amrubicin Shows Encouraging Results Compared to Standard of Care in Second Line Treatment of Small Cell Lung Cancer
2. Pharmion and MethylGene Report Preliminary MGCD0103 Clinical Data at the 2007 AACR-NCI-EORTC International Conference
3. Pharmion Initiates Pivotal Phase 3 Study of Amrubicin in Small Cell Lung Cancer
4. Pharmion and MethylGene Initiate Phase One Combination Clinical Trial with MGCD0103 and Taxotere(R) in Patients with Solid Tumors
5. Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Hodgkins Lymphoma
6. GlaxoSmithKline and Theravance Announce Start of Large Phase 2B ICS and LABA Studies for Asthma in the Horizon Program
7. Elekta Announces Clinical Start-Up of New Leksell Gamma Knife(R) Perfexion(TM) at UPMC
8. InterMune Announces Start of Phase 1b Trial of ITMN-191
9. Genzyme and Bayer Schering Pharma AG, Germany Announce Start of Phase 3 Program with Alemtuzumab for Treatment of Multiple Sclerosis
10. New Company Starts, Bridging the Development Gap in the Discovery of Cancer Drugs
11. GlaxoSmithKline Receives New HHS Order for H5N1 Bulk Antigen. First North American Clinical Trials with GSKs Candidate Pre-pandemic Flu Vaccine to Start.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... , Sept. 17, 2014 BRIC Biopsy Devices ... GlobalData,s new report, "BRIC Biopsy Devices Market Outlook ... Biopsy Devices market. The report provides value, in millions ... (in US dollars) within market segments - Biopsy Guns ... Fine Aspiration Needles (Disposable and Reusable Fine Aspiration Needles) ...
(Date:9/17/2014)... 17, 2014 The ambulance equipment ... decade due to the recession, an unstable ... advancements. This BCC Research report analyzes present ... the ambulance and emergency medical services equipment ... hemorrhage control devices, equipment used for burn ...
(Date:9/17/2014)... 2014 /PRNewswire-iReach/ -- ChemImage announced today the ... in the development of imaging technology used ... and diseased tissue that minimizes the learning ... lowers surgical costs and potentially enhances patient ... The clinical and scientific teams at ...
Breaking Medicine Technology:BRIC Biopsy Devices Market Outlook to 2020 2BRIC Biopsy Devices Market Outlook to 2020 3Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2
... , , DURHAM, N.C., Jan. 8 Oxygen ... common stock has been approved for listing on the NASDAQ ... to the NASDAQ is a very important milestone for our ... listed on the NASDAQ provides us with greater visibility for ...
... , , , FARMINGDALE, N.Y., Jan. ... of minimally invasive ultrasonic medical device technology, which in Europe ... other acute health conditions, has entered into a new, three ... in Riyadh, Kingdom of Saudi Arabia, for the distribution of ...
Cached Medicine Technology:Oxygen Biotherapeutics, Inc. Announces Approval for NASDAQ Listing 2Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 2Misonix Announces New Distribution Agreement for Kingdom of Saudi Arabia 3
(Date:9/17/2014)... Present-day Europeans are the descendants of at least ... new study. Previous research suggested that ... farmers. But, a new genetic analysis involving ancient ... of Ancient North Eurasians. Nearly all present-day Europeans ... researchers from Harvard Medical School said. , , ...
(Date:9/17/2014)... HealthDay Reporter WEDNESDAY, Sept. 17, 2014 (HealthDay ... why antibiotic-resistant bacteria can thrive in a hospital setting. ... the culprit. They can easily enter bacteria and move from ... makes bacteria drug-resistant, a new study finds. "The plasmids ... class of antibiotic called carbapenems," said the study,s co-author, Dr. ...
(Date:9/17/2014)... might be able to reduce the need for invasive ... autoimmune disease lupus. , In a new study, researchers ... from nephritis kidney inflammation to interstitial fibrosis, ... A kidney biopsy is the only existing way to ... extent. , The model could also be used to ...
(Date:9/17/2014)... 17, 2014 Today, Blue Shield ... in third-quarter grantmaking. This body of grants aims to ... innovations in care delivery, as well as to develop ... Grants will also strengthen the capacity of both domestic ... and create new entry points for domestic violence screening ...
(Date:9/17/2014)... 17, 2014 In a country where ... on a regular basis, how can Americans find healthy ... Hyland’s Stress Challenge , a 5-day interactive journey ... stress-free life. From September 29th – October 3rd, ... content relating to specific topics that promote natural solutions ...
Breaking Medicine News(10 mins):Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 2Health News:Europeans Are Descendants of at Least 3 Ancient Human Groups: Study 3Health News:Researchers Discover How Bacteria Resist Antibiotics in Hospitals 2Health News:Researchers Discover How Bacteria Resist Antibiotics in Hospitals 3Health News:Math model designed to replace invasive kidney biopsy for lupus patients 2Health News:Blue Shield of California Foundation Awards $5 Million in Third-Quarter Grants 2Health News:Stress Less with the Hyland's 5-Day Stress Challenge 2
... to this new research on mountain biking it is observed ... from University Hospital in Innsbruck, Austria,// presented his findings of ... extreme mountain bikers and 30 non-bikers took part in the ... more than two hours a day, six days a week, ...
... effective utility tool to the field of medicine. An ... about their treatment. The days when doctors told you ... expect to participate in the decision-making process. But sometimes ... messages and new research comes up all the time. ...
... are more likely to suffer from behavioural problems, a ... growth hormone not only boosted growth in children,// but ... ,Lead researcher Dr Derick Beens, professor of ... said: "We believe this work demonstrates that all very ...
... has always been an ongoing argument regarding the do's and ... suggest a new and better way through the dieting controversy.// ... fashion being the 'low carb' approach - for many decades ... at the 'no diet' women's retreat Green Mountain in the ...
... events in detail, older people recall more about thoughts, ... age - some researchers believe that it deteriorates,// others ... Psychologists in Toronto have been comparing how people of ... ,They studied a group of 15 younger ...
... is better than conventional treatment for managing asthma ... of immune cells known eosinophils increase// in the ... at how targeting this build up of eosinophils ... an asthma attack. ,The conventional treatment ...
Cached Medicine News:
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: