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Pharmion and MethylGene Report Preliminary MGCD0103 Clinical Data at the 2007 AACR-NCI-EORTC International Conference
Date:10/24/2007

- Safety and response data from Phase I/II MGCD0103 combination trial with

Gemzar(R) in patients with solid tumors presented -

- Preliminary evidence of activity in pancreatic cancer - - Phase II portion of the clinical trial in pancreatic cancer patients has

commenced -

BOULDER, Colo. and MONTREAL, Oct. 24 /PRNewswire-FirstCall/ -- Pharmion Corporation (Nasdaq: PHRM) and MethylGene Inc. (TSX: MYG) today reported preliminary clinical data from the Companies' MGCD0103 Phase I/II combination trial with Gemzar(R) (Trial 006). The data were presented in a poster session at the 2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco on October 24th, 2007.

In the poster entitled "Phase I/II: The oral isotype-selective histone deacetylase inhibitor MGCD0103 in combination with gemcitabine in patients with solid tumors," Herbert Hurwitz, M.D., Duke University Medical Center and principal investigator for this trial, described preliminary results for the dose escalation Phase I portion of this trial. The primary objective of the Phase I portion of this trial was to determine the maximum tolerated dose (MTD) of MGCD0103 in combination with Gemzar(R) (gemcitibine) in patients with solid tumors where gemcitibine is considered standard of care or refractory tumors. In the Phase I portion of the study, patients received an oral dose of MGCD0103 three times per week in 28-day cycles at escalating doses ranging from 50mg to 110mg. Gemzar was administered at the standard dose and schedule of 1,000mg/m2 once per week for three weeks followed by one week of rest. Results demonstrated MGCD0103 and Gemzar can be safely
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SOURCE Pharmion Corporation
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