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Pharmaxis Launches ARIDOL® (Mannitol Inhalation Powder) Bronchial Challenge Test Kit for the Assessment of Bronchial Hyperresponsiveness
Date:2/23/2011

al Allergy and Respiratory Disease Center, Sacramento, CA.  "The ARIDOL Bronchial Challenge Test offers health care professionals another tool to help with a disease that is often hard to definitively diagnose."  

"PHARMAXIS is committed to bringing our therapeutic advances for respiratory and immune diseases to patients throughout the world.  The U.S. launch of ARIDOL highlights this commitment and our focus on helping physicians and patients world-wide affected by respiratory illnesses," added Mr. Beckman.

How ARIDOL Works

The ARIDOL test requires patients to inhale increasing doses of dry powder mannitol from a simple, hand-held device, which causes airways to narrow and contract when airway inflammation is present. The doses are contained in capsules that are administered at one-minute intervals until a positive response is achieved or until all the capsules have been inhaled, indicating a negative result.  A positive response is indicated when there is a 15% reduction in lung function from baseline compared to a 20% fall required by a methacholine challenge test.(1) The lower the dose required to cause bronchoconstriction, the more severe the bronchial hyperresponsiveness.    

Other Bronchial Challenge Tests

Unlike other bronchial challenge tests, ARIDOL is a single-use test that requires less preparation time and eliminates reconstitution, use of a nebulizer to administer, clean-up and sterilization.  A positive ARIDOL test is complete in approximately 20 minutes, compared to an average of 45 minutes for a methacholine test.(2) A methacholine test requires additional equipment to administer and a designated testing room with ventilation.(1) Tests that use exercise to assess bronchial hyperreponsiveness require special equipment and conditions, and may not be appropriate for patients with physical limitations.

Safety/Efficacy Profile

The safety and efficacy
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SOURCE Pharmaxis, Inc.
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Related medicine technology :

1. Pharmaxis Previews New Bronchial Challenge Test at the Annual Meeting of the American College of Allergy, Asthma and Immunology
2. Pharmaxis Announces Positive Combined Phase 3 Cystic Fibrosis Trial Results
3. FDA Approves Pharmaxis ARIDOL™ (Mannitol Inhalation Powder) Bronchial Challenge Test Kit for the Assessment of Bronchial Hyperresponsiveness
4. Pharmaxis Announces Positive Results of Phase 3 Cystic Fibrosis Trial
5. Pharmaxis Announces Milestone in Phase III Trial for Cystic Fibrosis
6. Pharmaxis Announces New Drug Application Submission for Aridol(TM)
7. ASX/NASDAQ Media Release: Pharmaxis Files First Marketing Application for Bronchitol in Australia
8. Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial
9. Pharmaxis Establishes Named Patient Program for Bronchitol
10. Pharmaxis Long-Term Safety Study of Bronchitol Completes
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