Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy ... (gastrointestinal AEs wereobserved. There...)

Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers

Date:9/10/2007

gastrointestinal AEs were observed. There were no clinically significant changes in vital signs, electrocardiograms, hematologic, renal or other laboratory parameters. The plasma exposure to PSI-6130 and PSI-6206, the uridine metabolite of PSI-6130, increased with increasing doses of R7128. Food increased the exposure of PSI- 6130 by approximately 20%. Please see http://www.clinicaltrials.gov or e-mail clinicaltrials@pharmasset.com for more information.

"The single ascending doses of R7128 were generally safe and well- tolerated, and there was no maximum tolerated dose identified in this study," stated Dr. Michael J. Otto, Pharmasset's Executive Vice President, Pharmaceutical Research. "The pharmacokinetic profile of the prodrug indicates good exposure to the active moiety, PSI-6130, and no clinically significant dose-related adverse events or laboratory abnormalities were observed. We are pleased with these results and look forward to the continued development of R7128 for HCV."

Conference Call

Pharmasset will host a conference call at 8:30AM (ET) on Monday, September 10, 2007 to discuss the R7128 Phase 1 study results.

Dial-in Information:

Domestic callers: 1 (800) 811-0667 (US/Canada)

International callers: 1 (913) 981-4901 (International)

Live audio of the conference call will be simultaneously broadcast over the internet via a webcast. To access the live webcast, log on to the "Events & Presentations" section of the Investor Center on Pharmasset's corporate website at http://investor.pharmasset.com/events.cfm.

Please connect to the company's website at least ten minutes prior to the start of the presentation to ensure adequate time for a reliable connection and any software download that may be necessary to listen to the webcast. The arc
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SOURCE Pharmasset, Inc.
Copyright©2007 PR Newswire.
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Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy ...(gastrointestinal AEs wereobserved. There...),Health