Navigation Links
Pharmasset Initiates QUANTUM, a Phase 2b Interferon-Free Trial of PSI-7977 and PSI-938 for All HCV Genotypes
Date:9/13/2011

PRINCETON, N.J., Sept. 13, 2011 /PRNewswire/ -- Pharmasset, Inc. (Nasdaq: VRUS) announced today that screening has begun in a Phase 2b, international study of PSI-7977 and PSI-938, two nucleotide analog polymerase inhibitors for the treatment of chronic hepatitis C (HCV). The QUANTUM trial will evaluate interferon-free regimens of PSI-7977 400mg QD and PSI-938 300mg QD with and without ribavirin over 12 or 24 weeks in patients with HCV who have not been treated previously. The trial will also evaluate the use of PSI-938 monotherapy.

"We are encouraged by the early efficacy and safety data being generated with our nucleotide analogs, PSI-7977 and PSI-938," stated Michelle Berrey, MD, MPH, Pharmasset's Chief Medical Officer.  "The QUANTUM trial is the first interferon-free, all-nucleotide study with an SVR endpoint. The ability to include all HCV genotypes was supported by data from the NUCLEAR study and the interferon free arms of the ELECTRON trial. Data from ELECTRON are expected later this year."

About the Phase 2b QUANTUM Trial This study is designed to enroll approximately 450 patients with chronic HCV of all viral genotypes who have not been treated previously. The primary endpoint of the trial will be sustained virological response (SVR24). Patients will be equally randomized across the following arms:

  • PSI-938 only
  • PSI-938 and PSI-7977
  • PSI-7977 and ribavirin
  • PSI-938, PSI-7977, and ribavirin

  • All arms will be study for both 12 and 24 weeks with a placebo control of 24 weeks.

  • Placebo for 24 weeks

  • HCV patients will be stratified by IL28B status and baseline HCV RNA to ensure balance across cohorts. Cirrhotic and non-cirrhotic patients will be enrolled in the study.

    Additional details on this and all ongoing Pharmasset sponsored trials can be found at

    SOURCE Pharmasset, Inc.
    Copyright©2010 PR Newswire.
    All rights reserved

    Page: 1 2 3

    Related medicine technology :

    1. Pharmasset Announces Two-for-One Forward Stock Split
    2. Pharmasset to Present at Canaccord Genuity Growth Conference
    3. Pharmasset Reports Fiscal Third Quarter 2011 Financial Results
    4. Pharmasset Announces the Expansion of the ELECTRON Trial in Chronic Hepatitis C
    5. Pharmasset to Present at Two Upcoming Investor Conferences
    6. Pharmasset Reports Fiscal Second Quarter 2011 Financial Results
    7. Pharmasset Initiates Phase 2b ATOMIC Trial of PSI-7977 for Multiple HCV Genotypes
    8. Pharmasset to Webcast an Investor Event From the EASL Meeting
    9. Pharmasset to Present at Three Upcoming Investor Conferences
    10. Pharmasset to Present at the Leerink Swann Hot Topics Roundtable Conference
    11. Pharmasset Reports Fiscal First Quarter 2011 Financial Results
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:8/4/2015)... Transparency Market Research has published ... Market (BambniTest, Harmony, informaSeq, MaterniT21 PLUS, NIFTY, Panorama, PrenaTest, ... Volume, Share, Growth, Trends and Forecast 2014 - 2022 ... published by Transparency Market Research " Non-invasive Prenatal Testing ... Trends and Forecast 2014 - 2022 ", the global ...
    (Date:8/4/2015)... Research and Markets ( http://www.researchandmarkets.com/research/nl392k/alcohol ) has announced the ... (Household & Personal Care, Pharmaceutical, Oilfield, Agrochemicals, and Others) ... report to their offering. The market ... in 2014 and is projected to grow at a ... data mentioned in the report is based on the ...
    (Date:8/4/2015)... SAN DIEGO , Aug. 4, 2015  Mirati Therapeutics, ... focusing on genetic and epigenetic drivers of cancer, will be ... August 11, 2015 at 1:55 p.m. ET (10:55 a.m. PT) ... Baum , M.D., Ph.D., president and CEO of Mirati, will ... of the presentation will be accessible on the "Investors" page ...
    Breaking Medicine Technology:Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 2Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 3Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 4Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 5Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 2Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 3Mirati Therapeutics To Present At The 2015 Wedbush PacGrow Healthcare Conference 2Mirati Therapeutics To Present At The 2015 Wedbush PacGrow Healthcare Conference 3
    ... YORK, Feb. 1, 2011 Reportlinker.com announces that a ... Pen Injectors ... of an increasing number of drugs in pre-filled disposable ... pens at the expense of other drug delivery methods ...
    ... Reportlinker.com announces that a new market research report ... Fludarabine - Comprehensive patent search ... with the industry benchmark in comprehensive patent information. ... professional patent search performed by our expert team, ...
    Cached Medicine Technology:Reportlinker Adds Fludarabine - Comprehensive Patent Search 2Reportlinker Adds Fludarabine - Comprehensive Patent Search 3Reportlinker Adds Fludarabine - Comprehensive Patent Search 4
    (Date:8/4/2015)... ... August 04, 2015 , ... ... product packaging, and fulfillment services, joined over 200 other Long Island-based corporations as ... on Tuesday, July 28th at Jones Beach State Park in Wantagh, New York. ...
    (Date:8/4/2015)... ... August 04, 2015 , ... Patients are invited to ... the world renowned Beverly Hills facelift surgeon , Dr. Paul Nassif. The ... helps individuals to achieve an outer appearance that meets their personal goals. This ...
    (Date:8/4/2015)... ... August 04, 2015 , ... Montclair State University and Atlantic Health System have ... kind in New Jersey, which starting this Fall will help prepare those entering this ... with Atlantic Health System, one of the largest health care organizations in New Jersey, ...
    (Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... nursing homes and other long-term care facilities, today announced details of the Advanced ... nursing homes and centers. , Providigm’s QAPI Accreditation program , introduced in ...
    (Date:8/4/2015)... Vegas, Nevada (PRWEB) , ... August 04, 2015 ... ... FEMALE, a striking contemporary look at unique artistic expressions from a diverse group ... inside the Life Is Beautiful Music & Art Festival on September 25-27, 2015 ...
    Breaking Medicine News(10 mins):Health News:NutraScience Labs "Steps Up" to the 2015 Marcum Workplace Challenge 2Health News:Beverly Hills Surgeon, Dr. Paul Nassif, is Now Offering Personal Consultations with Full Examinations for Facial Plastic Surgeries 2Health News:Beverly Hills Surgeon, Dr. Paul Nassif, is Now Offering Personal Consultations with Full Examinations for Facial Plastic Surgeries 3Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 2Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 3Health News:Nursing Homes Achieving New Advanced Accreditation See Improved Measures of Quality, Better Occupancy Rates 2Health News:Nursing Homes Achieving New Advanced Accreditation See Improved Measures of Quality, Better Occupancy Rates 3Health News:Sin City Gallery Rocks Life Is Beautiful Festival with INTIMATELY FEMALE at Art Motel 2Health News:Sin City Gallery Rocks Life Is Beautiful Festival with INTIMATELY FEMALE at Art Motel 3Health News:Sin City Gallery Rocks Life Is Beautiful Festival with INTIMATELY FEMALE at Art Motel 4
    ... arrest patients treated with hypothermia may be withdrawn too soon ... awakening that,s not apparent for a week several days ... researchers said. For more than 25 years, the prognosis ... care has been based on a neurological exam at 72 ...
    ... HealthDay Reporter , FRIDAY, Nov. 12 (HealthDay ... as "stroke centers of excellence" or "chest pain centers," ... stroke and heart attacks. But current programs for ... best cardiovascular or stroke care are falling short, according ...
    ... , FRIDAY, Nov. 12 (HealthDay News) -- Talking to ... once they,re in school, researchers say. Children whose parents ... the cardinal number principle -- the size of a set ... counting the set, the University of Chicago researchers found. ...
    ... missed a "Mac" in 28 years. At 44, he,s one ... receive the designation of "goat" once they,ve completed 20 or ... Mich. Armstrong has sailed the race every year since he ... July. Instead, he was in intensive care awaiting heart transplant ...
    ... spend about a third of our lives asleep. So there ... that sleep helps consolidate memories, fixing them in the brain ... showing that sleep also seems to reorganize memories, picking out ... produce new and creative ideas, according to the authors of ...
    ... Research Center, Emory University, will present a wide range ... annual meeting in San Diego, Nov. 13-17, 2010. The ... Yerkes scientists will be discussing. To learn more about ... Research Center and the other seven national primate research ...
    Cached Medicine News:Health News:Saturday news tips: Resuscitation Science Symposium 2Health News:Saturday news tips: Resuscitation Science Symposium 3Health News:Saturday news tips: Resuscitation Science Symposium 4Health News:Saturday news tips: Resuscitation Science Symposium 5Health News:Setting National Hospital Standards Could Boost Cardiac Care 2Health News:Setting National Hospital Standards Could Boost Cardiac Care 3Health News:Myocarditis can attack hearts without warning 2Health News:Sleep makes your memories stronger 2Health News:Yerkes researchers present at 40th Annual Society for Neuroscience Conference 2Health News:Yerkes researchers present at 40th Annual Society for Neuroscience Conference 3Health News:Yerkes researchers present at 40th Annual Society for Neuroscience Conference 4Health News:Yerkes researchers present at 40th Annual Society for Neuroscience Conference 5
    Algerbrush II corneal rust ring remover battery powered...
    Katena ophthalmic burr for polishing pterygiums, includes one round diamond burr and has an storage case....
    ... TW full diameter trial lens set has ... twenty years. While maintaining only the highest ... the Marco 35-6 TW trial lens set ... by adhering to strict industry guidelines, and ...
    Khosla Mini Non-Illuminated Trial Lens Set, With Lenses Mounted...
    Medicine Products: