Navigation Links
Pharmasset Announces R7128 Achieves 85% Rapid Virologic Response in a 4-week Combination Study for the Treatment of Chronic Hepatitis C
Date:1/7/2008

- 85% of patients achieve undetectable HCV RNA levels following 4 weeks of treatment with R7128 1500mg and Pegasys(R) plus Copegus(R) with safety and

tolerability comparable to placebo -

- Conference Call Scheduled for 4:00PM ET Today -

PRINCETON, N.J., Jan. 7 /PRNewswire-FirstCall/ -- Pharmasset, Inc. (Nasdaq: VRUS) announces the preliminary results of a 4-week Phase 1 clinical trial to evaluate two oral dose levels of R7128 in combination with Pegasys (pegylated interferon) plus Copegus (ribavirin) in 50 treatment-naive patients chronically infected with hepatitis C virus (HCV) genotype 1. In this study, R7128 demonstrated potent short-term antiviral activity and was generally safe and well-tolerated. Eighty-five (85%) of patients receiving R7128 1500mg and Pegasys plus Copegus achieved undetectable HCV RNA levels following 4 weeks of treatment with safety and tolerability comparable to placebo. R7128 is a prodrug of PSI-6130, a cytidine nucleoside analogue polymerase inhibitor of HCV that is being developed through Pharmasset's collaboration with Roche.

Dr. Michelle Berrey, Pharmasset's Chief Medical Officer, stated "R7128, in combination with Pegasys plus Copegus, has shown that nucleoside polymerase inhibitors can demonstrate Rapid Virologic Response (RVR) percentages that are similar to protease inhibitors with an acceptable short-term clinical safety profile. This study also suggests that there appear to be certain synergies between nucleoside polymerase inhibitors and the standard of care that is not found with other classes of HCV inhibitors. The addition of R7128 at both dose levels to the current standard of care has demonstrated a greater percentage of RVR compared to the standa
'/>"/>

SOURCE Pharmasset, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART
2. Pharmasset Commences Dosing in 28-Day Combination Study of R7128 with Pegasys(R) plus Copegus(R) for Hepatitis C
3. Pharmasset Commences Dosing in Phase 3 Registration Studies of Clevudine for HBV
4. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
5. Maxygen Announces Positive Progress in Phase IIa Clinical Trial of Novel PEG-GCSF
6. Jazz Pharmaceuticals, Inc. Announces Receipt of FDA Orphan Drug Designation for Recurrent Acute Repetitive Seizures Product Candidate
7. Innocoll Announces Dosing of First Patient in US Phase 2 Clinical Trial to Investigate CollaRx(R) BUPIVACAINE SURGICAL IMPLANT for the Management of Post-operative Pain
8. Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection
9. QuatRx Pharmaceuticals Announces Positive Phase 3 Results for Study of Ophena(TM) (ospemifene) to Treat Postmenopausal Vaginal Syndrome
10. AmpliMed Corporation Announces Promising 1-year Survival Data from Phase I/II Study of Amplimexon(R) in Metastatic Malignant Melanoma
11. NicOx Announces Pfizer Initiates Phase 2 Clinical Development for PF-03187207 in Japan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... June 30, 2015 Nortek Security & ... NTK ) and a leader in the residential ... announced it acquired mobile personal emergency response system ... Numera, Inc. Headquartered in ... implemented, mobile PERS products and cloud-based software platforms ...
(Date:6/30/2015)... 2015   Millar, Inc. , a leader in ... 2016 retirement of Craig Thummel , President/CEO and ... of service to the Company. The Company also announced ... of the Executive Management team as his successors. The ... currently Director of Sales and Marketing, as President, and ...
(Date:6/30/2015)... , June 24, 2015 ... announced the addition of the "Global Array ... The global array instruments market to ... the period 2014-2019 The global array instruments ... microarrays, protein microarrays, and others including tissue microarrays ...
Breaking Medicine Technology:Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 2Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 3Nortek Security & Control Acquires Health and Wellness Technology Business from Numera 4Millar, Inc. Announces Leadership Changes 2Millar, Inc. Announces Leadership Changes 3Global Array Instruments Market 2015-2019 - Advances in Personalized Medicines with Affymetrix, Agilent Technologies & Illumina Dominating 2
... Jan. 27, 2011 /PRNewswire-Asia/ -- China Sky One ... Company") (Nasdaq: CSKI ), a leading ... of China ("PRC"), today announced that Heilongjiang Tianlong ... subsidiary, was named a "Top Ten Branded Company ...
... Cetero Research, the leading early-stage contract research organization ... industry milestone with the completion of its 20,000th ... as the unmatched leader in early-phase clinical development ... therapeutic expertise that Cetero offers to pharmaceutical, biotechnology ...
Cached Medicine Technology:China Sky One Medical Receives Medical Industry Awards 2China Sky One Medical Receives Medical Industry Awards 3Cetero Research Announces Completion of 20,000th Early-Phase Clinical Study 2
(Date:6/30/2015)... Richey, FL (PRWEB) , ... June 30, 2015 , ... ... nearly doubled from 2007 to 2013 while heroin-related deaths more than tripled in the ... drug threat (1). Novus Medical Detox Center , a leading Florida-based drug treatment ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... that they have been awarded the exclusive billing agreements with Jackson Radiology Associates ... billing services encompassing their proprietary suite of billing process software functionality called Experience ...
(Date:6/30/2015)... ... June 30, 2015 , ... On June 26, 2015, Harper’s Bazaar Magazine ... triggers that most people would not expect to cause acne flare-ups. The ... causes of acne are clogged pores and bacteria and each of the ...
(Date:6/30/2015)... FL (PRWEB) , ... June 30, 2015 , ... ... Jacksonville, reported today it has more than doubled the size of its medical ... The center’s medical staff -- which includes physicians, nurse practitioners and physician assistants ...
(Date:6/30/2015)... ... , ... Family and professional dementia caregivers are invited to ... 2015 at the Hyatt Regency Denver Tech Center from 7:30 am-4:30 pm. The ... the wife and daughter of singer Glen Campbell, who will discuss their experiences ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:ADVOCATE Wins Billing Agreements with Jackson Radiology Associates 2Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2Health News:Lakeview Health, a Nationally Recognized Drug Rehabilitation Center in Florida, Doubles Size of Medical Staff 2Health News:Family of Singer Glen Campbell to Discuss Living with Dementia at the Alzheimer's Association of Colorado's 26th Annual Education Symposium 2
... initiatives can pay,off for organizations, although developing reliable ... But the more mature the quality,programs, the greater ... quality metrics, according to recent research from benchmarking,leader ... percent of the firms that described their quality,programs ...
... could be a vital indicator for treating narrowing of lung ... research shows that people with chronically high blood pressure in ... levels have a very high mortality rate. , ... a known indicator of advanced left heart failure, but the ...
... Travel Advantage Network manager shaves head in fundraising ... Advantage,Network (TAN), a nationwide leader in wholesale vacation ... funds for juvenile alopecia,areata, an autoimmune disorder that ... body, usually the scalp., TAN,s Total Vacation ...
... CLARA, Calif., June 20 The Continua Health,Alliance ... at 2:30 p.m. at the Santa,Clara Convention Center, ... Conference and Showcase., The session, "The next ... three use cases -- chronic disease management, aging,independently, ...
... Cash Security of $5.2 Million Lifted, SALT ... SNCI ), the only U.S.-based publicly traded ... company,s German subsidiary,successfully negotiated an amendment with Commerzbank ... the 2003 acquisition of the German subsidiary. The,amendment ...
... York, NY -- The Damon Runyon Cancer Research ... at its May 2008 Clinical Investigator Award Committee ... award are outstanding early career physician-scientists conducting patient-oriented ... mentorship of the nation,s leading scientists and clinicians. ...
Cached Medicine News:Health News:Measuring and Demonstrating the Value of Quality Initiatives 2Health News:Low Blood Sodium Predicts Mortality in PAH Patients 2Health News:TAN Employees Shave the Way for the Fight Against Alopecia 2Health News:Continua Health Alliance to Host Open Meeting at CONNECTIONS(TM) Tuesday, June 24th at 2:30 pm 2Health News:Sonic Innovations Announces Loan Amendment With German Bank 2Health News:Sonic Innovations Announces Loan Amendment With German Bank 3Health News:Damon Runyon Cancer Research Foundation awards $2.25M to 5 top young clinical investigators 2Health News:Damon Runyon Cancer Research Foundation awards $2.25M to 5 top young clinical investigators 3
... Integra II SP MRI-Compatible Anesthesia System is perfect ... more than one type of anesthetic agent. ... and due to its wider stance, has a ... ventilator bellows assembly is utilized in both the ...
... Market leader in soft tissue repair in ... has developed the latest evolution in orthopedic ... ORTHOCORD Suture is as strong as any ... importantly, ORTHOCORD Suture handles like ETHIBOND®., ,ORTHOCORD ...
... PURPLE NITRILE* product family offers a comprehensive ... gloves were designed as an alternative for ... hypersensitivity to natural rubber latex proteins. The ... from latex and other synthetic gloves. Custom ...
... and the distinctive COLOR PURPLE* distinguish ... them for sterile clinical procedures when ... required. Theyre designed as an alternative ... Type 1 hypersensitivity to natural rubber ...
Medicine Products: