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Pharmacyclics Reports Updated Clinical Results from its Phase IA Trial of its First in Human Btk-Inhibitor PCI-32765
Date:12/7/2010

ORLANDO, Fla. and SUNNYVALE, Calif., Dec. 7, 2010 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC) today announced results from the Phase IA study of its novel orally administered Bruton's tyrosine kinase (Btk) inhibitor, PCI-32765, in patients with relapsed or refractory B cell malignancies. The abstract titled "The Btk Inhibitor, PCI-32765, Induces Durable Responses with Minimal Toxicity in Patients with Relapsed/Refractory B-Cell Malignancies: Results from a Phase I study" is being presented by Nathan Fowler, MD at the 2010 Annual Meeting of the American Society of Hematology (ASH) today at 8:15 am in Orlando, FL.

Data Results from the Phase IA Study of PCI-32765The study enrolled 56 relapsed or refractory patients with a variety of B cell malignancies to this multi-cohort dose-escalation trial. Forty-eight of these patients are evaluable for response. The response by disease is captured below in the table.

The Phase IA study enrolled patients with multiple disease histologies including CLL/SLL, follicular lymphoma, mantle cell lymphoma, DLBCL, Marginal/Malt and Waldenstrom.  The progression-free survival varies by histology.  We have described the time on study results by histology.  Please refer to our website at http://ir.pharmacyclics.com/events.cfm to review the slides presented by Dr. Nathan Fowler at the 2010 Annual Meeting of the American Society of Hematology.NCRSDPDNE*TETE*ORR % of ITT**

ORR % of Eval**

ASCO 2010 ORR% of Eval**Chronic/Small  Lymphocytic Leukemia (CLL/SLL)16

1

8**2

0

2

1

56%**

(9/16)

69%**

(9/13)82%**

(9/11)Follicular Lymphoma (FL)16

1

3

5

4

325%

(4/16)

31%

(4/13)

27%

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SOURCE Pharmacyclics, Inc.
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