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Pharmacyclics Reports Third Quarter 2013 Results
Date:11/7/2013

agent. Enrollment in stage I of dosing cohorts 1-4 is complete with a total of 67 patients enrolled. At this time, an expansion of cohorts 1 and 2 is not planned due to the fact that the protocol-defined response rate was not achieved. Dosing of the enrolled patients in cohorts 3 and 4 is continuing.
  • PCYC-1119: Phase I/IIb study of ibrutinib in combination with carlfizomib in patients with R/R MM was registered in the third quarter of 2013. The Phase I portion of this study is a dose escalation study designed to the safety and recommended Phase IIb dose of ibrutinib and carlfizomib. The Phase IIb portion will be a randomized, double-blind, placebo controlled study to evaluate the efficacy of ibrutinib and carlfizomib versus carlfizomib and placebo. The primary endpoint of the Phase IIb portion of the study is progression-free survival. Pharmacyclics plans to enroll up to 176 patients.
  • Conference CallThe Company will hold a conference call today at 4:30 p.m. ET. To participate in the conference call, please dial 1-877-303-7908 for domestic callers and 1-678-373-0875 for international callers. To access the live audio broadcast or the subsequent archived recording, log on to http://ir.pharmacyclics.com/events.cfm. To access a replay of the call please dial 1-855-859-2056 domestic callers and 1-404-537-3406 for international callers and use the conference ID number: 92632034.  The archived version of the webcast and conference call will be available for 30 days on the Investor Relations section of the Company's Web site at http://www.pharmacyclics.com.

    About ibrutinibB-cells are the immune cells in the body that are responsible for producing antibodies to fight infections and provide long term immunity. Ibrutinib is a B-cell receptor pathway inhibitor that interferes with the proteins involved in signaling and it effectively blocks signals tha
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