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Pharmacyclics Reports Second Quarter 2014 Results
Date:7/31/2014

s 180 patients.

In the second quarter, we provided significant preclinical updates in chronic graft versus host disease (GvHD) and solid tumors (Her2-posivtive breast cancer) which led to the publication of two abstracts at the American Association of Cancer Research (AACR). Since then we initiated our first trial with IMBRUVICA in GvHD. The study is a Phase Ib/II investigating the safety and efficacy of IMBRUVICA in patients with chronic GVHD who are steroid dependent or refractory. The study is currently recruiting with a total planned enrollment of 39 patients.

During the three months ended June 30, 2014, we provided updates on several of our clinical programs in various press releases and filings with the Securities and Exchange Commission. Pharmacyclics participated in three prominent medical conferences, the American Association for Cancer Research (AACR) in San Diego, Ca, the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, IL, and the 19th European Hematology Association (EHA) Congress in Milan, Italy. The oral presentation of the Phase III RESONATETM and its inclusion in the official press program during the 50th Annual ASCO meeting was a historical milestone for the Company and captured the attention of the scientific community, as well as worldwide media outlets. The data also were validated at the EHA Congress in Milan where they were presented during the presidential symposium with approximately 4,000 hematologists in attendance. During these scientific conferences, IMBRUVICA was presented in four oral sessions and in 14 posters covering results in seven histologies (i.e., CLL, small lymphocytic lymphoma, HCL, MCL, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma).

IMBRUVICA (ibrutinib) – Selected Clinical Trial UpdatesChronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

  • RESONATE™ (PCYC-1112): Phase III study of IMBR
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