Navigation Links
Pharmacyclics Reports Recent Developments From Clinical Studies of its Btk Inhibitor PCI-32765
Date:6/6/2011

ypes of DLBCL, the activated B-cell (ABC) subtype and the germinal center (GC) subtype. We have enrolled 3 out of the planned 60 patients and expect to complete enrollment in the first quarter of calendar 2012. Other trials evaluating the combination of PCI-32765 with chemotherapy in DLBCL are under development.

A separate pilot study of PCI-32765 in patients with ABC subtype DLBCL is currently being conducted at the NIH Clinical Center. Thus far, 8 out of a planned 10 patients have been enrolled. While it is too early to report full results of this study, objective responses, including complete responses, have been observed. We anticipate that this study once completed will be submitted for presentation at the 2011 American Society of Hematology Meeting

-- Follicular Lymphoma (FL)
Updated results from the Phase IA study have shown an improvement in the objective response rate in follicular lymphoma. We are encouraged by this preliminary signal and are developing a Phase II program in this histology. We anticipate the initiation of a Phase II trial in follicular lymphoma in the first half of 2012.

-- Multiple Myeloma (MM)
Ongoing pre-clinical studies, both internally as well as through external collaborations, have suggested a vital role for Btk in both malignant plasma cells and osteoclasts, which are involved in the bone complications of this disease. Therefore, we believe that Btk represents a viable therapeutic target in MM, and we are developing a Phase II trial of PCI-32765 in MM, which we expect to initiate in early 2012.

"In February 2009 Pharmacyclics dosed the first patient with PCI-32765, a Bruton tyrosine kinase irreversible inhibitor. Bottom line, we have now dosed 230 patients across multiple hematologic histologies. The results have exceeded the expectations of most all involved to this point in time. We look forward to continued progress as well as playing a meaningful role in the comin
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
2. Pharmacyclics Announces Preclinical Results Supporting Development of Its Novel Btk Inhibitor in Immune Mediated Diseases
3. Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors
4. Pharmacyclics Novel Factor VIIa Inhibitor Demonstrates Potential Inhibition of Tumor Growth in Multiple Types of Cancer
5. Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma
6. Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483
7. Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.
8. Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkins Lymphoma
9. Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier
10. Pharmacyclics to Present at Merriman Curhan Fords Investor Summit 2009
11. Pharmacyclics Announces Poster Presentations and Clinical Update at the 51st Annual Meeting of the American Society of Hematology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)...  SI-BONE, Inc., a medical device company that pioneered ... the sacroiliac (SI) joint with the iFuse Implant System ... have now been performed world wide utilizing more than ... iFuse procedure continues to grow and gain momentum with ... the United States and 17 countries ...
(Date:3/2/2015)... BETHESDA, Md. , March 2, 2015  Celimmune ... and preventing autoimmune diseases, announced today that it has ... from Amgen (NASDAQ: AMGN ). Under the ... rights to develop, manufacture and commercialize AMG 714 on ... Concurrently, Amgen has been granted an exclusive option to ...
(Date:3/2/2015)... ANGELES , March 2, 2015 ImmunoCellular Therapeutics, Ltd. ... financial results for the year ended December 31, 2014 on March ... conference call and webcast on Thursday, March 12, 2015, at 5:00 ... , President and CEO.   , ... dial-in: (631) 291-4544; conference code 92238648. , , , ...
Breaking Medicine Technology:SI-BONE, Inc. Announces 15,000 iFuse Procedure Milestone 2SI-BONE, Inc. Announces 15,000 iFuse Procedure Milestone 3Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 2Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 3ImmunoCellular Therapeutics to Report 2014 Financial Results on March 9, 2015; a Business Update Conference Call and Webcast is Scheduled for March 12, 2015 2
... JOSEPH, Mo., April 14, 2011 On Monday, April ... Veterinary cardiologists on the Mobile Dog Heart Health Tour ... free dog heart examinations at Seger Dog Park. ... to providing free heart health screenings, veterinarians will be ...
... GlaxoSmithKline (GSK) is committed to ensuring that consumers and ... alli is safe and effective when used as directed. ... locally in the gastro-intestinal tract. GSK continues to proactively ... relevant information with regulatory agencies. Since orlistat ...
Cached Medicine Technology:Veterinarians to Perform Free Dog Heart Health Screenings in Philadelphia on April 18 2Veterinarians to Perform Free Dog Heart Health Screenings in Philadelphia on April 18 3
(Date:3/2/2015)... 02, 2015 The Alliance for Bangladesh ... expert Mark Chubb to serve as chief safety officer. ... and training in Bangladesh and guide remediation efforts in ... “Mark will ensure that the Alliance continues to bring ... for Bangladesh garment workers,” said Alliance Independent Chair Ellen ...
(Date:3/2/2015)... Viejo, California (PRWEB) March 02, 2015 ... release of the TranStatic Volume 2 from Pixel Film Studios. ... transitions made exclusively for FCPX,” said Christina Austin, CEO of ... to have in any Final Cut Pro X editors toolbox.” ... scene to the next with media altering static scrambling effects ...
(Date:3/1/2015)... 2015 As residents and business ... Michael Burns and Carita Weaver, believe in supporting ... with the Southlake Chamber of Commerce, Carroll Independent ... recently launched a website for Southlake mayoral candidate ... communications tool for Hill’s campaign, the website combines ...
(Date:3/1/2015)... 2015 Adults who are not legally ... term or universal policies can now use the QuotesPros.com ... life insurance companies for single adults can now be ... http://quotespros.com/life-insurance.html . , The rate plans that nationwide agencies ... to a number of life protection policies. The term, ...
(Date:3/1/2015)... 2015 The number of transvaginal mesh ... past few weeks in two New Jersey litigations where ... the Firm announces. , A Case List updated ... Bergen County proceeding established for products manufactured by Johnson ... weeks earlier, when 90 fewer cases had been centralized. ...
Breaking Medicine News(10 mins):Health News:Alliance for Bangladesh Worker Safety Names New Chief Safety Officer 2Health News:Pixel Film Studios released the TranStatic Volume 2 plugin for Final Cut Pro X today 2Health News:Website Launched for Southlake, Texas Mayoral Candidate Laura Hill 2Health News:Best Life Insurance Companies for Single Adults Now Searchable at Insurance Website 2Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 2Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 3Health News:Bernstein Liebhard LLP Comments on Case List Growth in New Jersey Transvaginal Mesh Litigations, Where Firm Attorneys are Representing Hundreds 4
... on Finding Solutions to Healthcare Crisis Affecting Communities of ... Voices: Healthcare for the Underserved today announced the second ... to be held April 30 - May 1, 2009 ... The conference, themed "Strengthening Families During Incarceration and ...
... animal testing encouragingBELGRADE, Serbia, Feb. 2 /PRNewswire-FirstCall/ - ... announced the results of preliminary testing of a ... the use of a combination of drugs; ribavirin ... ribavirin and tiazofurin in combination attenuated or weakened ...
... surgery for acute shoulder dislocation may provide the best ... million children and adolescents participate in organized athletics and ... of shoulder injuries that occur in these young athletes ... to a paper published in the February 2009 issue ...
... U.S. Department of Health and Human Services (HHS) ... standards developed by the Healthcare Information Technology ... Specifications" - documents that harmonize and recommend the ... electronic health records and help support the nationwide ...
... of fibroblasts during development also promotes their ability to ... in the February 9, 2009 issue of the ... epithelial cells into fibroblast-like mesenchymal cells is a critical ... factor Snail1 induces this conversion (known as epithelialmesenchymal transition, ...
... An online survey of 1,888,physicians, medical group ... U.S. physician groups are eager to accept a ... incentives,designed to promote broader adoption of information technologies ... (Logo: http://www.newscom.com/cgi-bin/prnh/20081013/AQM041LOGO ) , ...
Cached Medicine News:Health News:Community Voices: Healthcare for the Underserved Announces Second Annual Freedom's Voice Conference and Awards Gala 2Health News:Community Voices: Healthcare for the Underserved Announces Second Annual Freedom's Voice Conference and Awards Gala 3Health News:Hard To Treat Diseases (HTDS) Announces Initial Research Results on Potential MS Therapy 2Health News:Immediate Orthopaedic Care Can Help Heal a Young Athlete's Shoulder 2Health News:Immediate Orthopaedic Care Can Help Heal a Young Athlete's Shoulder 3Health News:HHS Secretary Recognizes Products of HITSP Standards Work 2Health News:HHS Secretary Recognizes Products of HITSP Standards Work 3Health News:HHS Secretary Recognizes Products of HITSP Standards Work 4Health News:Fibroblasts invade at a snail's pace 2Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 2Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 3Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 4Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 5Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 6Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 7Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 8Health News:Allscripts Survey of Healthcare Professionals Demonstrates Potential Impact of Economic Stimulus Plan on Electronic Health Record Adoption 9
... the pioneers of surgical lighting, including ... automatic reserve bulb, an integrated surgical ... sets the standard for advanced lighting ... our latest generation surgical light ...
... SimpliCT® is an interventional guidance device ... significantly improve the accuracy of computed ... to improving accuracy, SimpliCT® also has ... of CT-guided puncture procedures including biopsies ...
Flat tip, bare fiber, no cooling, polished SMA 905, 3 meters long. Sold in boxes of five. Each part is individually packaged in sterile Tyvek bags....
Get YAG laser performance from your diode laser. Our proprietary NA shift technology offers efficient coupling of low divergence fiber to high divergence lasers...
Medicine Products: