Navigation Links
Pharmacyclics Reports Recent Developments From Clinical Studies of its Btk Inhibitor PCI-32765
Date:6/6/2011

this study were presented today at the 2011 Annual Meeting of ASCO and the full ASCO presentation is posted on our website.

Two ongoing studies, initiated in Q1 2011, are evaluating PCI-32765 in combination with standard therapies for CLL/SLL. We have enrolled 34 patients in these studies and anticipate completing enrollment in 2011.

From these studies, we expect to be able to analyze initial 3-month safety data for ofatumumab/PCI-32765 and bendamustine/rituximab/PCI-32765 in the second half of 2011. To date the preliminary safety data from these combination studies suggests that these combinations are likely to be safe.

Based on the significant single-agent activity in CLL/SLL from the ongoing Phase IB/II trial, and contingent upon confirmation of 3-month combination safety data, Phase III planning is currently underway. We expect to initiate a Phase III study in CLL/ SLL in the first half of 2012.  

-- Mantle Cell Lymphoma (MCL)
A Phase II study of single-agent PCI-32765 in relapsed or refractory MCL (PCYC-1104) began enrolling patients in late February 2011. To date, we have enrolled 30 patients on this trial and anticipate completing enrollment by the end of calendar 2011. Initial review of early data from this ongoing study suggests that the high overall response rate observed in Phase I is likely to be similar in Phase II. We anticipate submitting an abstract with interim results for presentation at the 2011 American Society of Hematology (ASH) Meeting. Contingent upon the ongoing analysis of PCYC-1104, we will soon begin Phase III planning in MCL. We anticipate that a Phase III study will be initiated in 2012.

-- Diffuse Large B-Cell Lymphoma (DLBCL)
A multicenter, open-label, Phase II study of PCI-32765 in patients with relapsed or refractory DLBCL (PCYC-1106) began enrollment in May 2011. This study is designed to assess the activity of PCI-32765 in two genetically distinct subt
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
2. Pharmacyclics Announces Preclinical Results Supporting Development of Its Novel Btk Inhibitor in Immune Mediated Diseases
3. Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors
4. Pharmacyclics Novel Factor VIIa Inhibitor Demonstrates Potential Inhibition of Tumor Growth in Multiple Types of Cancer
5. Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma
6. Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483
7. Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.
8. Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkins Lymphoma
9. Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier
10. Pharmacyclics to Present at Merriman Curhan Fords Investor Summit 2009
11. Pharmacyclics Announces Poster Presentations and Clinical Update at the 51st Annual Meeting of the American Society of Hematology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31, 2015  In today,s ever-changing marketplace, call centers ... mobile, increasingly connected, and increasingly impatient with slow service. ... interaction channels and tools is driving call centers to ... According to research by benchmarking firm, Best ... segment in a call center study realize the impact ...
(Date:7/31/2015)... July 31, 2015 Today, the National ... ® ) issued a report urging greater accountability ... is taken against websites illegally selling medications online. ... Outlet Identification Program Progress Report for State and ... thousands of websites illegally distribute medications and avoid ...
(Date:7/31/2015)... 31, 2015  Boston Children,s Hospital physicians report ... printing of their anatomy before undergoing high-risk brain ... (abnormalities in the brain,s blood vessels) that posed ... in the Journal of Neurosurgery: Pediatrics , ... and synthetic resins to create custom, high-fidelity models ...
Breaking Medicine Technology:Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 33D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4
... , NEW ... new market research report is available in its ... Trends , http://www.reportlinker.com/p0164299/Surgical-Incision-Closures---Global-Trends.html , Surgical ... the millions of surgical procedures being performed each ...
... , NEW YORK, Nov. 30 Reportlinker.com ... its catalogue: , Diabetes Diagnostics - A Global Market ... market is driven by a steady increase in the number ... developing parts of the world, and increase in intensive management ...
Cached Medicine Technology:Reportlinker Adds Surgical Incision Closures - Global Trends 2Reportlinker Adds Surgical Incision Closures - Global Trends 3Reportlinker Adds Surgical Incision Closures - Global Trends 4Reportlinker Adds Surgical Incision Closures - Global Trends 5Reportlinker Adds Surgical Incision Closures - Global Trends 6Reportlinker Adds Surgical Incision Closures - Global Trends 7Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 2Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 3Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 4Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 5Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 6Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 7Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 8Reportlinker Adds Diabetes Diagnostics - A Global Market Perspective 9
(Date:8/1/2015)... (PRWEB) , ... August 02, 2015 , ... Back packs ... in a school, however, back packs can wreck havoc on a kid's spine. With ... their supplies to and from school. Make sure you are aware of how to ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... Have you ever wondered what “Karma” really ... you hear the word “Karma.” , Vedic tradition, which gave birth to Hinduism, is ... one of the central concepts of this tradition. According to the wisdom of this heritage, ...
(Date:8/1/2015)... , ... August 01, 2015 , ... Calvary Hospital today ... housed at their Bronx campus. The goal is to bring this Torah – dating ... used in Jewish rituals and religious services. , Scroll No. 515, from the ...
(Date:8/1/2015)... ... August 01, 2015 , ... Brig and Lita Hart, icons of ... unification of their Healthy Home mission with the HOPE Movement of EvolvHealth. In what ... of both companies have agreed to join their missions of purpose together to change ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... On Tuesday, ... group , who are thought to have been behind the attack on Anthem Inc. ... covered were zero day exploits, watering hole attacks and spear phishing campaigns. ...
Breaking Medicine News(10 mins):Health News:Local AlignLife Doctor Donates Time to Check Back Packs 2Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4
... Go Healthy, Inc. (Pink Sheets: GOHE) announced today that the ... firm. The firm, Lonnie T. Morgan, Esq. of Minneapolis, ... connections and relations developed during his many years in investor ... HEALTHY products are vital to addressing the health needs of ...
... diabetes diagnostics market is poised for expansion with segments ... growth potential. Heightened efforts to generate awareness about diabetes ... market development. For instance, limited awareness about HbA1C tests ... be curtailed with more education about the test. , ...
... ... Case Reviews ($695) and Expert Witness Reports ($995) for a limited time, making these ... a new quality control service to ensure that its clients, Expert Witness Reports are ... , ...
... , ... on Emergency Department Experiences Released Today, Available at www.ImproveMyER.com , ... South Bend, Ind. (Vocus) June ... quality improvement solutions, today released the ,2009 Emergency Department Pulse Report: Patient Perspectives on ...
... Company Exemplifies Firm,s Strategy in the Field of Medical ... Sofinnova Partners of Paris, France today announced having ... company CoAxia. The round also included participation from ... Canaan Ventures Partners, Johnson and Johnson Development Corporation, and ...
... PITTSBURGHA new algorithm developed by Carnegie Mellon University ... how genetic networks in the fruit fly, Drosophila ... have known that the relationships between fruit fly ... can not capture the details of those changes ...
Cached Medicine News:Health News:Go Healthy Announces Association With Business Development Firm 2Health News:Frost & Sullivan: Self-Monitoring and POC Diabetes Tests Reveal Potential for Significant Growth, Boosting the European Diabetes Diagnostics Market 2Health News:Frost & Sullivan: Self-Monitoring and POC Diabetes Tests Reveal Potential for Significant Growth, Boosting the European Diabetes Diagnostics Market 3Health News:American Medical Experts Offers New Reduced Flat Rates for Complete Case Reviews ($695) and Expert Witness Reports ($995) 2Health News:American Medical Experts Offers New Reduced Flat Rates for Complete Case Reviews ($695) and Expert Witness Reports ($995) 3Health News:American Medical Experts Offers New Reduced Flat Rates for Complete Case Reviews ($695) and Expert Witness Reports ($995) 4Health News:Patients Spent an Average of Four Hours and Three Minutes in U.S. Emergency Departments in 2008, According to Latest Press Ganey Report 2Health News:Patients Spent an Average of Four Hours and Three Minutes in U.S. Emergency Departments in 2008, According to Latest Press Ganey Report 3Health News:Patients Spent an Average of Four Hours and Three Minutes in U.S. Emergency Departments in 2008, According to Latest Press Ganey Report 4Health News:Sofinnova Partners Leads Investment Round in CoAxia 2Health News:Sofinnova Partners Leads Investment Round in CoAxia 3Health News:Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle 2Health News:Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle 3
For the quantitative determination of high density lipoprotein (HDL) in human serum....
... Intended for the ... in plasma. Two vials, ... Enzymatic, alphaketoglutarate. Uses NADPH ... other plasma compounds. Reaction: ...
... The Proteomeworks system is an ... technologies that enables protein function ... sample preparation, 2-D electrophoresis, staining, ... excision, automated protein digestion, mass ...
Storage temperature: 2 - 8C, linearity: 0 - 700 mg/dL, expected values: 30 - 780 mg/dL. Available with calibrator and number of tests 110....
Medicine Products: