Navigation Links
Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors
Date:4/15/2008

SAN DIEGO and SUNNYVALE, Calif., April 15 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC) today announced preclinical data from four presentations at the Annual Meeting of the American Association for Cancer Research (AACR) being held this week in San Diego, CA. Results from multiple preclinical studies on the company's novel, histone deacetylase (HDAC) inhibitor and HDAC-8 selective inhibitor were presented.

"These presentations demonstrate the breadth of our research and development programs, and highlight our strong collaborations with academic leaders," said Richard A. Miller, M.D., president and CEO of Pharmacyclics. "Our lead HDAC inhibitor, PCI-24781, is now in Phase 1 clinical trials in patients with advanced solid tumors, and we anticipate initiating a Phase 1/2 study in lymphoma in the second quarter of calendar 2008; both studies will incorporate the use of biomarkers to predict tumor sensitivity to drug treatment."

Three studies were presented on Pharmacyclics' lead HDAC inhibitor, PCI-24781. PCI-24781 has been shown to inhibit all forms of HDAC enzymes to target a broad range of cancer types, including colon, breast, lung, prostate, and ovarian cancers, as well as glioma.

-- In laboratory studies conducted in collaboration with scientists at the

University of Texas M.D. Anderson Cancer Center, PCI-24781 demonstrated

inhibition of NFkB, a transcription factor known to drive tumor growth.

-- In a separate study also conducted in collaboration with M.D. Anderson,

researchers found that PCI-24781 was active in transgenic animal models

of gallbladder cancer and other solid tumors. Treatment of animals with

resistant gallbladder tumors that
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Pharmacyclics Announces Preclinical Results Supporting Development of Its Novel Btk Inhibitor in Immune Mediated Diseases
2. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
3. Medarex Reports Interim Data from Ongoing Ipilimumab Combination Phase 1 Studies in Prostate Cancer at American Association for Cancer Research Meeting
4. NOLabs AB Reports Success in Fight Against Bacteria Causing Urinary Tract Infection
5. Enanta Reports New Macrolide-Related Drug Class, Bicyclolides, to Combat Hospital and Community Acquired Superbug Infections, Including MRSA
6. MAP Pharmaceuticals Reports Positive Results From Phase 2a Clinical Trial of Combination Therapy in Adult Asthmatics
7. Catalyst Pharmaceutical Partners Reports Fourth Quarter and Year-End 2007 Financial Results
8. Rexinoid Developed by NuRx Pharmaceuticals Shows Promise in Prevention, Treatment of Lung, Breast Cancer, Paper in Clinical Cancer Research Reports
9. MAP Pharmaceuticals Reports Positive Results From Comparative Pharmacokinetic Trial for its Pediatric Asthma Product Candidate
10. New Study Reports That Physical Therapy Treatment Resolves Symptoms of Urinary Incontinence in Women
11. Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 2014  Array BioPharma Inc. (Nasdaq:   ARRY) ... quarter and full year of fiscal 2014 ... those results on Tuesday, August 12, 2014.  ... Michael Carruthers , Chief Financial Officer will ... 2014Time:9:00 a.m. Eastern TimeToll-Free:(800) 708-4540Toll:(847) 619-6397Pass Code: ...
(Date:7/28/2014)... 28, 2014  MedSpring Urgent Care, an Austin ... S. Lamar Blvd., Austin, TX 78704 on ... on the southeast corner of Barton Springs Rd. and ... - 9 p.m. daily, including weekends and holidays. With ... Central Austin , Anderson Mill , Cedar ...
(Date:7/28/2014)... 28, 2014  TNI BioTech, Inc. (OTCQB: TNIB) ... on the development, marketing and distribution of opioid-related ... proxy materials with the Securities and Exchange Commission ... Shareholders to be held on Thursday, September 4, ... record date for determining those shareholders eligible to ...
Breaking Medicine Technology:MedSpring Urgent Care opens Barton Springs walk-in clinic in Austin, TX 2TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 2TNI BioTech, Inc., Files Definitive Proxy Materials; Mails Letter Urging Shareholders to Vote the Proxy Card 3
... ANGELES, March 2, 2011 InstaCare Corp. (OTC Bulletin ... prescription and non-prescription diagnostics, home testing products for the ... patient diabetes programs, and a leading developer of revolutionary ... the company,s Board of Directors has received a patent ...
... Assured Pharmacy (Pink Sheets: APHY ), a leading ... sufferers of chronic pain announced that total sales on a ... $1,514,984 which equates to $70,464 per business day.  It represents ... of $1,348,344 for December 2009 which equates to $62,714 per ...
Cached Medicine Technology:InstaCare Announces Receipt of Technology and Patent Value Analysis Penned by Joseph Wolf, Ph.D and William Walling, CFA 2InstaCare Announces Receipt of Technology and Patent Value Analysis Penned by Joseph Wolf, Ph.D and William Walling, CFA 3Assured Pharmacy Reports Same Store Sales for the Month of December 2010 2Assured Pharmacy Reports Same Store Sales for the Month of December 2010 3
(Date:7/28/2014)... 2014 SIMpalm helped its client ... is available on iTunes for download . Experience a ... Chef allows you to listen and cook along with expert ... simply get out the ingredients and equipment, press play, and ... prepare ingredients ahead of time, just relax and cook along ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Parker Waichman LLP, ... fighting to ensure that the heroes of 9/11 are never ... has announced an important deadline. According to a VCF ... with a covered cancer on or before October 12, 2012 ... 2014. First responders and others who were allegedly injured by ...
(Date:7/28/2014)... Dearborn, Michigan (PRWEB) July 28, 2014 ... from Drs. Harris, Birkhill, Wang, Songe and Associates, PC ... generations and countless tomorrows to come. , The ... group, responsible for more than $2.5 million in donations. ... the title sponsors for the Oakwood Women’s Healthcare Classic ...
(Date:7/28/2014)... NY (PRWEB) July 28, 2014 The ... organization that has donated more than 200,000 books to ... 2001, announces the launch of Brooke’s Cooks, a new ... while encouraging healthy living among at-risk children and their ... will include a series of nutrition information workshops, cooking ...
(Date:7/28/2014)... somethinglike the meal you,ve ordered at a restaurantor ... sweep through your brain. , These waves ... symphony of cellsboth excitatory and inhibitoryplaying together in ... debated, gamma waves have been associated with higher-level ... been tied to schizophrenia, Alzheimer,s disease, autism, epilepsy ...
Breaking Medicine News(10 mins):Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 4Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 2Health News:October 12, 2014 Deadline Approaching for 9/11 First Responders Suffering from Certain Cancers to Submit Their Registration to the VCF, Parker Waichman LLP Comments 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 2Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 3Health News:Brooke Jackman Foundation Launches Brooke's Cooks, New Initiative to Promote Healthy Living Among At-Risk Youth and Their Families 4Health News:Memory relies on astrocytes, the brain's lesser known cells 2Health News:Memory relies on astrocytes, the brain's lesser known cells 3
... adolescent sexual and reproductive health issues, and this can ... elders, says a new report by the International Center ... ,More than half the population in India is ... suffer serious reproductive health problems but face constraints in ...
... of the American College of Gastroenterology suggests that illness ... with mothers who have Irritable Bowel Syndrome (IBS) may ... one-on-one contact with their mothers. ,Researcher ... Washington looked at survey data from 631 children of ...
... working in Iraq admit that more than half of the ... and more experienced staff and were available.// ,Writing ... that as the violence escalates, the reality is that they ... from Iraqi authorities and UN agencies suggest that more than ...
... attitude towards one's ethnic identity can help teenagers manage ... according to a new study.// ,Lisa Kiang ... Forest University studied 415 ninth-graders from Chinese and Mexican ... participants had an impact on their daily psychological well-being, ...
... Health Organization has reported that for every four adults ... overweight, 30% of them clinically obese.// ,Obesity ... one day cripple economies. WHO says that although it ... still constitutes a global epidemic. ,Statistics show ...
... been reported in Canada following two cases of paralysis when ... ,According to reports by the local media the ... from Toronto. It is not known when the third case ... California and sold under the names Bolt house Farms 100 ...
Cached Medicine News:Health News:Intervention Needed to Break 'Silence' on Reproductive Health 2Health News:Intervention Needed to Break 'Silence' on Reproductive Health 3Health News:Gender and Family Size Influences IBS Symptoms in Children 2Health News:Scourge of Obesity 2
Suture Cutter, Open Ended, Left Notch...
Threaded cannula with cannulated obturator for use with Acufex Suture Punch; sterile packs, box of 10....
...
...
Medicine Products: