Navigation Links
Pharmacyclics Reports Financial Results for Fiscal 2010 and for Fourth Quarter 2010
Date:9/13/2010

hibitor, PCI-27483, is currently being evaluated in a multicenter Phase I/II randomized study in patients with locally advanced or metastatic pancreatic cancer. As planned, we have completed the Phase I portion of this Phase I/II trial and have successfully advanced to Phase II. In the Phase II portion of this study each pancreatic cancer patient will receive a maximum of 12 weeks of treatment with gemcitabine alone or gemcitabine plus PCI-27483. As of to date we have dosed 11 pancreatic cancer patients and the study continues enrolling in the randomized Phase II segment of the trial. We anticipate completing enrollment of 46 patients in the second half of 2011.
  • Histone deacetylase (HDAC) Inhibitor, PCI-24781, is the company's orally-bioavailable HDAC Inhibitor that disrupts DNA repair and contributes to tumor cell death. In 3 Phase I clinical trials, conducted in patients with hematologic or solid tumors, clinical response or control of tumor growth has been observed following single-agent therapy with our HDAC Inhibitor. Pharmacyclics' HDAC Inhibitor has demonstrated a good safety profile in approximately 90 patients treated so far; the main dose-limiting toxicity was a rapidly reversible thrombocytopenia, which we believe is related to the pharmacologic mechanism of action. The magnitude of thrombocytopenia can be attenuated by modification of the treatment schedule. The Phase II portion of our ongoing trial is continuing in patients with follicular and mantle cell lymphoma.  Results are anticipated in the second half of 2011. To date we have enrolled 7 follicular and 3 mantle cell patients; so far in this study 1 patient had a partial response and 4 patients have reported stable disease after 2 cycles.
  • The HDAC Inhibitor PCI-24781 has also shown synergy in preclinical testing with several approved cancer therapeutics. A Phase I/II trial in sarcoma patients is ongoing and is co-sponsored by prominent investigators at Massachuse
    '/>"/>

  • SOURCE Pharmacyclics
    Copyright©2010 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

    Related medicine technology :

    1. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
    2. Pharmacyclics Announces Preclinical Results Supporting Development of Its Novel Btk Inhibitor in Immune Mediated Diseases
    3. Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors
    4. Pharmacyclics Novel Factor VIIa Inhibitor Demonstrates Potential Inhibition of Tumor Growth in Multiple Types of Cancer
    5. Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma
    6. Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483
    7. Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.
    8. Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkins Lymphoma
    9. Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier
    10. Pharmacyclics to Present at Merriman Curhan Fords Investor Summit 2009
    11. Pharmacyclics Announces Poster Presentations and Clinical Update at the 51st Annual Meeting of the American Society of Hematology
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:9/15/2014)... , Sept. 15, 2014  Catalist-listed QT Vascular Ltd. ... a developer and manufacturer of minimally invasive medical devices ... announce that the Group has enrolled the first European ... . Multiple patients have already been enrolled in ... Auckland City Hospital, in Auckland, New Zealand ...
    (Date:9/15/2014)...  Over 200 patients, families, physicians and scientists ... interact and participate in the drive for better ... Fair launched by the Lupus Research Institute ... .  Attendees interacted directly with researchers at eight ... and needs and learning about more than 80 ...
    (Date:9/15/2014)... DUBLIN , Sept. 15, 2014 Research ... "The Worldwide Market for In Vitro Diagnostic Tests, 9th Edition" ... volume covers the entirety of the clinical testing market and ... Used by Top IVD Companies For Business Planning. ... volume based on the market events of 2013 and early ...
    Breaking Medicine Technology:First European Patients Enrolled in QT Vascular's ENDURE Trial 2First European Patients Enrolled in QT Vascular's ENDURE Trial 3First European Patients Enrolled in QT Vascular's ENDURE Trial 4First European Patients Enrolled in QT Vascular's ENDURE Trial 5Lupus Research Institute Launches NYC's First Lupus Trials Fair 2Lupus Research Institute Launches NYC's First Lupus Trials Fair 3The Worldwide Market for In Vitro Diagnostic Tests, 9th Edition 2The Worldwide Market for In Vitro Diagnostic Tests, 9th Edition 3
    ... Texas, Oct. 7 Wound Management Technologies, Inc. ... medical products, announced today that the company will actively participate at ... Conference (SALSAL) that opens in Orlando tomorrow, October 8. ... the conference, the company will conduct a workshop entitled ...
    ... 6 New Momentum, a leading provider of SaaS-based ... to help pharmaceutical companies combat the escalating problem of ... , According to the Center for Medicine in the ... by 13% annually -- nearly twice the pace of ...
    Cached Medicine Technology:Wound Management to Participate at Save A Leg, Save a Life Foundation National Conference 2Wound Management to Participate at Save A Leg, Save a Life Foundation National Conference 3New Momentum Teams With Oracle to Help Reduce Counterfeiting in the Life Sciences Industry 2
    (Date:9/16/2014)... Dr. Eric Millstein of Beverly Hills is ... a specialty website devoted to the diagnosis and treatment ... lover and athlete, Dr. Millstein focuses on offering patients ... to maintain active, healthy lifestyles. , “We’re very excited ... specifically to ACL injuries and treatment,” says ...
    (Date:9/16/2014)... 16, 2014 Lambda Solutions, a leader in ... is excited to welcome Stewart Rogers on board ... Executive at Lambda Solutions comments, “Product leadership will take Lambda ... to do so. Learning and talent management is at a ... help clinical learning and talent development in the past ten ...
    (Date:9/16/2014)... Texas (PRWEB) September 16, 2014 Online ... be offering $0 shipping on all kettlebell purchases in ... easy for customers to get started with this effective ... the Crossfit movement. The online store carries a variety ... and free weekly workouts guides. , “We’ve ...
    (Date:9/16/2014)... justthoughtyoushouldknow.org , popular current events, ... new site today. The new site is better ... information easier to find, ingest, and share. , ... easy-to-read pages the information that we believe any ... retired college professor and founder of the site. ...
    (Date:9/16/2014)... 2014 Dakota Software , ... (EHS) and Sustainability management software, today announced that ... versatile software platform, MobileWorkflows, at their Annual Users ... MobileWorkflows allow for on-the-go access to Dakota’s enterprise-level ... Responsive Web Design, MobileWorkflows feature a streamlined user ...
    Breaking Medicine News(10 mins):Health News:Los Angeles Orthopedic Surgeon Spotlights ACL Conditions With New Website 2Health News:Los Angeles Orthopedic Surgeon Spotlights ACL Conditions With New Website 3Health News:Stewart Rogers Joins Lambda Solutions as Director of Product Management 2Health News:Stewart Rogers Joins Lambda Solutions as Director of Product Management 3Health News:Join the Kettlebell Movement - Kettlebell Kings Announces $0 Shipping on all Orders 2Health News:JustThoughtYouShouldKnow.org Debuts New Website 2Health News:Mobile EHS Compliance Tools the Focus of Dakota Software’s 2014 Users Conference 2
    ... In the report titled Millennium Ecosystem Assessment, scientists have said ... having a detrimental effect to human health and may cause ... malaria and cholera are threatening to cause a major outbreak ... beneficial factors of the eco system are being used in ...
    ... published in American Journal of Public Health, researchers had been ... causes of asthma in children by interventions due to health ... children in the age group of 4 to 12 yrs ... period of one year during which community health workers used ...
    ... US and Canadian scientists, consuming food with high glycemic index ... ,The study, which had spanned 16.6 years and observed ... that the risk is much significant for women who are ... often found in foods that have simple carbohydrates and sugars ...
    ... a data comprising of 5461 girls between 11 to 15 ... these girls more prone to stress fractures. ,The study ... physical activity, which often lasts for 16 or more hours ... of having a stress fracture than the girls doing physical ...
    ... market watchdog Food and Drug Administration had announced a series ... class of non-steroidal anti-inflammatory drugs that are sold with or ... of the drug Bextra (valdecoxib) from Pfizer, Inc. ... FDA had reports that the overall risk associated with the ...
    ... have completed the second phase of testing of the ... of cervical cancers and 90% of genital warts. ... for 36 months and regularly had gynecological examination, cervicovaginal ... serum antibodies to HPV. , ,The results showed ...
    Cached Medicine News:
    ... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
    ... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
    ... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
    ... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
    Medicine Products: