7

7

29%2

1

4II2.5

9

7

57%

1

3

1

2

2III5

6

5

60%

1

2

1

1

1IV8.3

8

7

43%

1

2

3

1

1Continuous8.3

10

9

67%

1

5

2

1

1V12.5

7

6

50%3

31Total47

41

51%

4

17

11

9

610%

41%

27%

22%

15%*   Evaluable number of patients: Patients who completed 2 cycles of treatment and or had at least 1 on treatment tumor assessment done

** Definitions:

RR%: Response Rate of evaluable patients.

PR: partial response is defined as a > 50% tumor reduction and meets  international working group criteria for CLL (2008) and/or Cheson 2007 criteria for NHL.

CR: is a complete response, as defined by the former criteria.

SD: is a stable disease (for additional information and full definition please see our website www.pharmacyclics.com)

PD: is a progressive disease

NE: non-evaluable patients