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Pharmacyclics Reports Financial Results and Recent Developments for Fiscal Year and Fourth Quarter 2011 - Conference Call Set for Today at 4:30 PM EDT
Date:9/12/2011

ophosphamide and rituximab; or BR = bendamustine and rituximab) in subjects with CLL or SLL lymphoma. This trial is active in several US sites and completed enrollment with 30 of 30 patients to the BR cohort. We anticipate providing an update of safety results from this study concurrent with releases that are planned for calendar Q4 2011.
  • PCYC-1109:  A Phase IB/II study of PCI-32765 in combination with ofatumumab in subjects with relapsed or refractory CLL or SLL is ongoing and enrolled 33 patients as of the end of August, 2011. We anticipate providing an update on safety results from this study concurrent with releases that are planned for calendar Q4 2011.

  • Ongoing pre-clinical studies, both internally as well as through external collaborations, have suggested a potentially vital role for Btk in both malignant plasma cells and osteoclasts, which are involved in the bone complications of this disease. Therefore, we believe that Btk represents a viable therapeutic target in Multiple Myeloma and we are on track to initiate a Phase II trial of PCI-32765 in this disease in Q1 of calendar 2012.

  • Factor VIIa InhibitorA multicenter Phase I/II of PCI-27483 in patients with locally advanced or metastatic pancreatic cancer that are either receiving or are planned to receive gemcitabine therapy is currently ongoing.  The Phase II portion of the study is enrolling and patients are being randomized to receive either gemcitabine alone or gemcitabine plus PCI-27483. The objectives is to assess the safety of FVIIa Inhibitor PCI-27483 at pharmacologically active dose levels, to assess potential inhibition of tumor progression and to obtain initial information of the effects on the incidence of thromboembolic events. Currently we have enrolled 23 patients in the Phase II portion of this trial and we expect to complete enrollment of our planned 40 patients by Q1 of calendar 2012.

    Histone Deacetylase (HDAC) Inhibito
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    1. Pharmacyclics Announces Date of Fiscal Year End 2011 Financial Results and Conference Call
    2. Pharmacyclics Reports Recent Developments From Clinical Studies of its Btk Inhibitor PCI-32765
    3. Pharmacyclics Announces Oral Presentations and Clinical Update at Upcoming Medical Meetings
    4. Pharmacyclics to Announce Third Quarter Fiscal 2011 Results and Host a Conference Call on May 4, 2011
    5. Pharmacyclics to Announce Second Quarter Fiscal 2011 Results and Host a Conference Call on February 4, 2011
    6. Pharmacyclics Reports Updated Clinical Results from its Phase IA Trial of its First in Human Btk-Inhibitor PCI-32765
    7. Pharmacyclics Reports CLL Results from Preclinical and Clinical Studies of its Btk Inhibitor PCI-32765
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