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Pharmacyclics Reports CLL Results from Preclinical and Clinical Studies of its Btk Inhibitor PCI-32765
Date:12/5/2010

phocytosis may achieve a PR by standard response criteria with continued therapy.

(Photo: http://photos.prnewswire.com/prnh/20101205/SF12271)

Based on the pooled analysis from the Phase Ia study (~8 months median follow-up) and the Ib/II study (<2 months median follow-up) in this group of CLL/SLL patients, of the 45 evaluable patients, one patient achieved a CR (2%), 16 (36%) achieved a PR and an additional 19 (42%) have experienced a dramatic reduction in lymph node disease with lymphocytosis. When evaluating nodal disease alone, 87% percent (34 out of 39) of patients achieved a 50% or greater reduction in lymph node burden.  In patients with symptomatic disease, this early response was often associated with improvement in symptoms.

PCI-32765 continues to be well tolerated in this patient population.  Grade 3/4 events were uncommon. More common grade1/2 events were diarrhea and other GI and constitutional symptoms.  No hepatic or renal laboratory adverse events were reported on this trial and significant hematologic events were infrequent. There was no evidence of cumulative toxicity.

ASH Conference Call and Webcast Details:Date: Wednesday, December 8, 2010Time: 4:30 pm ETSlides used in Presentation: http://ir.pharmacyclics.com/events.cfm Listen via Internet: http://ir.pharmacyclics.com/events.cfm Live Participant Dial In (Toll Free): 877-407-8133 Live Participant Dial In (International): 201-689-8040 To access the live audio broadcast or the subsequent archived recording, log on to http://ir.pharmacyclics.com/events.cfm. The archived version of the webcast will be available for 30 days on the Investor Relations section of the company's Web site at www.pha
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