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Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma
Date:6/9/2008

mediated diseases. The inhibition of B-cell function and proliferation in the various models, including lymphomas, forms the basis for our phase 1 clinical trial, which is anticipated to begin in the fourth quarter of calendar 2008."

Btk is a critical enzyme involved in B-cell activation and mast cell function, and inhibition of its function may be useful in the treatment of immune mediated diseases. Mast cells play a key role in the inflammatory process and are implicated in the pathology associated with the autoimmune disorders, such as RA and in allergy. Recently, mast cells have been found to play an important role in tumor growth and angiogenesis. B-cells are a type of white blood cell that normally play an important role in the body's immune response. However, when B-cells are overactive, the immune system produces inflammatory cells and antibodies that begin to attack the body's own tissue, leading to autoimmune disorders. Most lymphomas are caused by uncontrolled growth of B-cells where activation of the B-cell receptor and Btk signaling are thought to play important roles.

About Pharmacyclics

Pharmacyclics is a pharmaceutical company developing innovative products to treat cancer and other serious diseases. The company is leveraging its small-molecule drug development expertise to build a pipeline in oncology and other diseases based on a wide range of targets, pathways and mechanisms. More information about the company, its technology, and products can be found at http://www.pharmacyclics.com. Pharmacyclics(R) and the "pentadentate" logo(R) are registered trademarks of Pharmacyclics, Inc.

NOTE: Other than statements of historical fact, the statements made in this press release about plans for initiating a Phase 1 study for PCI-32765, and other future plans for our clinical trials, progress of and reports of results from preclinical and clinical studies, clinical developmen
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SOURCE Pharmacyclics, Inc.
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