Navigation Links
Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma
Date:4/13/2009

> 8:00 am - 12:00 pm Poster Session Kinase Inhibitors 3 Experimental and Molecular Therapeutics 24 Hall B-F, Poster Section 36

8:00 am - 12:00 pm Poster Board Number 24

#3740 A Clinical Trial of the Bruton's Tyrosine Kinase (Btk) Inhibitor PCI-32765 in Naturally Occurring Canine Lymphoma. Lee A. Honigberg, Ashley M. Smith, David J. Loury, Joseph J. Buggy, Douglas H. Thamm. Pharmacyclics, Sunnyvale, CA, Colorado State University Animal Cancer Center, Fort Collins, CO

About Pharmacyclics' Btk Inhibitor Program

PCI-32765 is currently targeted for oncology while other Pharmacyclics Btk inhibitors are being developed for application to autoimmune and inflammatory diseases. Bruton's tyrosine kinase is a critical enzyme involved in B-cell activation and function, and inhibition may be useful in the treatment of a number of immune mediated diseases. B-cells are a type of white blood cell that normally play an important role in the body's immune response. However, when B-cells are overactive, the immune system produces inflammatory cells and antibodies that begin to attack the body's own tissue, leading to autoimmune disorders. Also many lymphomas are caused by uncontrolled growth of B-cells where activation of the B-cell receptor and Btk signaling are thought to play important roles.

In addition to being studied in a Phase 1 trial for refractory B-cell non- Hodgkin lymphoma, PCI-32765 has been evaluated in preclinical studies in collagen-induced arthritis, an established animal model for RA. In these studies, PCI-32765 dramatically reduced inflammation and induced regression of established disease as reported at the Federation of Clinical Immunology Societies (FOCIS) 2008 annual meeting .

About B-cell Non-Hodgkin's Lymphoma

Lymphoma is cancer of the lymphatic system, an integral part of the immune system, and is typically classi
'/>"/>

SOURCE Pharmacyclics
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Pharmacyclics, Inc. Announces Closing of a Private Financing With the Principals of Pacific Biopharma Group, Ltd.
2. Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483
3. Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma
4. Pharmacyclics Novel Factor VIIa Inhibitor Demonstrates Potential Inhibition of Tumor Growth in Multiple Types of Cancer
5. Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors
6. Pharmacyclics Announces Preclinical Results Supporting Development of Its Novel Btk Inhibitor in Immune Mediated Diseases
7. Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor
8. Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)
9. Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes
10. Healthpoint Initiates Phase II, Dose-Finding Study to Evaluate Effectiveness of a Unique Cell Based Therapy in Venous Leg Ulcers
11. Aerovance Initiates Phase IIb Clinical Trial with Aerovant(TM) for the Treatment of Uncontrolled Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... LONDON , December 15, 2014 /PRNewswire/ ... Am 19. und 20. Februar ... das Aegate SAFE MEDICINE ECOSYSTEM PARTNER PROGRAMM ... zu besuchen. Diese Tagung ... Gemeinschaft die Möglichkeit geben, die neue profitablen ...
(Date:12/15/2014)... -- BerGenBio AS, a biopharmaceutical company focused ... today announces that it has raised NOK90 million (c. ... existing investors. BerGenBio will use the proceeds ... pipeline of innovative cancer therapeutics, in particular an enlarged ... a first-in-class selective Axl kinase inhibitor, which is currently ...
(Date:12/15/2014)... , December 15, 2014 Investor-Edge ... ZGNX ), Eli Lilly and Company (NYSE: ... Sanofi (NYSE: SNY ), and Novartis AG (NYSE: ... can be accessed at: http://investor-edge.com/register . On ... down 1.16%, the Dow Jones Industrial Average lost 1.79%, to ...
Breaking Medicine Technology:Symposium über Aegates Ecosystem-Partner-Programm für sichere Medikamente vom 19. - 20. Februar 2015 in Amsterdam 2BerGenBio Completes NOK90 Million Fundraising 2Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 2Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 3Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 4Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 5
... 2011 Pharmatek Laboratories, Inc., a premier contract ... announced that it has added spray drying to ... has purchased a Buchi B-290 Mini Spray Dryer ...  This technology can be used for both oral ...
... (NASDAQ: STXS ) today announced that executive management ... The Deutsche Bank Annual Health Care Conference ... of Stereotaxis, is scheduled to present an overview of the ... The JMP Securities Annual Research Conference in San Francisco. ...
Cached Medicine Technology:Pharmatek Laboratories Adds Spray Drying to Drug Development Services 2Stereotaxis to Present at Upcoming Investor Conferences 2Stereotaxis to Present at Upcoming Investor Conferences 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 No matter ... been able to eradicate the head louse parasite—a common ... for parents. Each year between six and twelve million ... the Miami-based lice removal treatment company comes to the ... and environmentally friendly. With its track record of customer ...
(Date:12/17/2014)... News) -- Expectant parents should leave prenatal picture-taking to ... Use of ultrasound imaging and heartbeat monitors to ... the agency warns. "Although there is a ... imaging and heartbeat monitors, prudent use of these devices ... an FDA biomedical engineer, said in an agency news ...
(Date:12/17/2014)... Kathleen Doheny HealthDay Reporter ... loss is rampant in America, and work commitment is a ... No. 1 sleep killer," said Dr. Mathias Basner, an assistant ... of Pennsylvania Perelman School of Medicine. A time-use survey ... that work is the main activity exchanged for sleep. Short ...
(Date:12/15/2014)... South Florida’s leading urgent care provider, MD ... daze of hassle, hustle, and bustle that can cause injuries ... burns when making special meals and heartburn after eating them, ... any time. To prevent this season of joy from becoming ... of helpful and healthful holiday tips to keep the season ...
(Date:12/15/2014)... -- Expert pilots process visual information more efficiently than ... decisions during landings, a new study shows. Landing ... to master, and 36 percent of all airplane crashes ... approach and landing. Researchers monitored the brain activity ... while they were at the controls of a flight ...
Breaking Medicine News(10 mins):Health News:Lice Troopers Announces New Lice Treatment Clinic in Coral Gables to Service Key Biscayne, Coconut Grove, Kendall, Brickell & South Miami 2Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2
... DROPS BE ON THE HORIZON? , Children with allergic ... increase tolerance to allergens that trigger asthma and, in ... meta-analysis, researchers from the University of Genoa in Italy ... 3 to 18 years) involving sublingual immunotherapy (SLIT) for ...
... Finding offers hope for curbing pediatric obesity epidemic in U.S. ... and computer time by half reduced the amount of food ... found. , The finding offers hope to the problem of ... percent of children ages 6 to 19 years old are ...
... , The most potent drug available for the treatment ... known as isotretinoin); however, little is known about the ... by which 13-cis RA combats acne has now been ... University College of Medicine, Hershey, who analyzed skin biopsies ...
... Process Analyzer World,s First UPLC PAT System, Tied Directly ... to Increased Production ... vision of,scientists worldwide to address challenges that couldn,t previously be,solved, ... at the 59th Pittsburgh Conference on Analytical Chemistry and,Applied Spectroscopy, ...
... National Institute of Diabetes and Digestive and Kidney ... health information to raise awareness about diabetes, digestive ... not yet diagnosed with these illnesses. The NIDDK ... health fairs, workplace health forums, family reunions, and ...
... Park Dental, a Twin Cities area,group dental ... Minnesota Dental,community for 40-years, announced today that it ... its practice from its Boston, Massachusetts-based,administrative services provider, ... the result of the settlement of a lawsuit ...
Cached Medicine News:Health News:Journal Chest -- March 2008 news briefs 2Health News:Journal Chest -- March 2008 news briefs 3Health News:Restricting TV and Computer Time Helps Kids Lose Weight 2Health News:JCI online early table of contents: March 3, 2008 2Health News:JCI online early table of contents: March 3, 2008 3Health News:JCI online early table of contents: March 3, 2008 4Health News:JCI online early table of contents: March 3, 2008 5Health News:JCI online early table of contents: March 3, 2008 6Health News:JCI online early table of contents: March 3, 2008 7Health News:JCI online early table of contents: March 3, 2008 8Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 2Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 3Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 4Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 5Health News:Waters UPLC and HDMS Ignite Scientific Ingenuity with New System Solutions at Pittcon 2008 6Health News:Park Dental Announces Separation From Its Administrative Service Provider 2Health News:Park Dental Announces Separation From Its Administrative Service Provider 3
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: