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Pharmacyclics Announces Poster Presentations and Clinical Update at the 51st Annual Meeting of the American Society of Hematology
Date:11/12/2009

ts had stable disease with the median length of stable disease being 15 weeks. Accrual will continue to the phase II component of the clinical trial. We plan to provide a material update to the ongoing Phase I/II clinical trials in the form of this poster presentation.

Title: A Phase I Dose Escalation Study of the Btk Inhibitor PCI-32765 in Relapsed and Refractory B Cell Non-Hodgkin Lymphoma and Use of a Novel Fluorescent Probe Pharmacodynamic Assay

           Date / Time:  Monday, December 7, 2009, 6:00 PM-8:00 PM
           Location:  Hall E (Ernest N. Morial Convention Center)
            Poster Board III-649
           Poster Session: Lymphoma: Chemotherapy, excluding Pre-Clinical
            Models Poster III
           Primary presenter: Dr. Daniel Pollyea, Stanford University

PCI-32765 is a novel agent which targets Btk and appears to be well tolerated. The unique pharmacodynamic endpoint suggests high levels of Btk inhibition even at the lowest dosing cohort. Two of 7 patients have stable disease (65 days and 135 days), 3 patients are not yet evaluable for response, and 2 have progressed. Dose escalation to subsequent cohorts is ongoing.

NOTE: This announcement may contain forward-looking statements made in reliance upon the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding our expectations and beliefs regarding our future results or performance. Because these statements apply to future events, they are subject to risks and uncertainties. The words "anticipate", "believe", "estimate", "expect", "expectation", "should", "would", "project", "plan", "predict", "intend" and similar expressions are intended to identify such forward-looking statements. Our actual results could differ materially from those projected in the forward-looking statements. Additionally, you should not c
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