Navigation Links
Pharmacyclics Announces Data Presentations for Ibrutinib in B-Cell Malignancies
Date:12/10/2013

y Reduces Clonal IgM Paraproteins and Serum Free Light Chains While Increasing Normal IgM, IgA Serum Levels, Suggesting a Nascent Recovery Of Humoral Immunity
Georg Aue, MD, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

This study demonstrated ibrutinib's impact on the recovery of humoral immunity equally amongst treatment naive and relapsed refractory CLL patients. Consistent with other reports we see little change in IgG levels in the first 12 months. Importantly, ibrutinib leads to a significant increase in both IgA and IgM serum levels, suggesting a beginning recovery of humoral immunity. The reduction of clonal light chains, a tumor marker, correlates with clinical response. In contrast, the increasing levels of the non-clonal light chain may herald a recovery of the normal B-cell (and possibly plasma cell compartment) raising the possibility that ibrutinib may selectively target CLL cells while allowing the re-growth of normal B-cells.

Poster Abstract #4166: Kinetics Of Chronic Lymphocytic Leukemia Cells In Tissues and Blood During Therapy With The BTK Inhibitor Ibrutinib
Dominik Wodarz, Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, CA

This two-compartment analysis provides greater insight into ibrutinib's mechanism of action in CLL. During ibrutinib therapy, on average 1.7% (± 1.1%) of the cells die per day in the blood, while in tissue 2.7% (± 0.99%) of the cells die per day. These death rates during treatment are approximately 3-5 times higher than those estimated in previous studies in the absence of treatment. The amount of CLL cells from the tissue that was redistributed into the blood during ibrutinib therapy accounted for an average of 23.3% (± 17%) of the calcula
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related medicine technology :

1. WuXi PharmaTech to Partner with Pharmacyclics
2. Pharmacyclics Reports Third Quarter 2013 Results
3. Pharmacyclics Announces Date of Conference call to discuss Financial Results for Third Quarter Ended September 30, 2013
4. Pharmacyclics Reports Second Quarter 2013 Results
5. Pharmacyclics Announces Date of Financial Results for Second Quarter Ended June 30, 2013 and Conference Call
6. Pharmacyclics Reports First Quarter 2013 Results
7. Pharmacyclics Announces Date of Financial Results for Three Months Ended March 31, 2013 and Conference Call
8. Pharmacyclics Triggers Fourth Milestone Payment for Enrollment of 5th Patient in Frontline Phase III CLL Study
9. Pharmacyclics Announces Third Breakthrough Therapy Designation for Ibrutinib from the U.S. Food and Drug Administration
10. Pharmacyclics, Inc. Prices Public Offering of Common Stock
11. Pharmacyclics, Inc. Announces Proposed Public Offering of Common Stock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 21, 2014   BioNano Genomics , the ... research centers to purchase an Irys™ System . ... Cancer Institute (NCI), NIH Intramural Sequencing Center (NISC) and ... obtaining a comprehensive view of a genome was ... does not deliver the scalability or reliability to ...
(Date:10/22/2014)... ANAHEIM, Calif. , Oct. 21, 2014 Influenza ... with flu-associated deaths in the United States ... influenza viruses are thought to spread is from person to ... Ebola has a serve way of death, but kills ... of Ebola is also done by human fluids including sweat, ...
(Date:10/22/2014)... 22, 2014 Sanomedics International Holdings, Inc. (OTCQB: ... Global Research & Data Services, demand for thermometers is ... through 2018, as demand for more accurate digital thermometers ... the world,s largest market for thermometers, and one of ... Sanomedics International Holdings, Inc. Sanomedics International Holdings ...
Breaking Medicine Technology:BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3WholeHealth Products is proud to be releasing its Influenza A and B combo test, on the heels of the announcing of its phase 2 completion of the Rapid Ebola Test 2Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2
(Date:10/25/2014)... 25, 2014 More than 50 Family ... Reception on Monday at the home of Jim and ... from guest speaker Dr. Winifred Lender on finding the ... Lender, a Santa Barbara psychologist, author and Noozhawk columnist, ... of living in the digital age. Our digital reality ...
(Date:10/25/2014)... Wisconsin (PRWEB) October 25, 2014 QueenBeeTickets.com ... for a great selection at affordable prices. Bob Seger ... Center Huntington Center and Nationwide Arena are going on ... , Click Here to browse the selection ... Band at QueenBeeTickets.com. , The famous singer is touring ...
(Date:10/25/2014)... supply to an arm or a leg before heart surgery ... to a new study. "During heart surgery we ... be able to operate on it. After some time without ... energy because it doesn,t get oxygen. When we shut off ... arm or a leg, the body prepares for an upcoming ...
(Date:10/25/2014)... 23, 2014 (HealthDay News) -- Current osteoporosis screening ... postmenopausal women at risk for osteoporosis-related fractures, a ... prevent fractures, we need tools that help us ... so that we can target these at-risk people ... professor of medicine in the division of general ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 On October ... Minds featuring skin diseases both fictional and real. ... (CEHMDF), a nonprofit organization committed to advocacy and philanthropy ... CBS will take the opportunity to impart truth and ... , There are many misconceptions about Morgellons ...
Breaking Medicine News(10 mins):Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:QueenBeeTickets.com Features Bob Seger & The Silver Bullet Band Tickets for Charleston Civic Center, Huntington Center, and Nationwide Arena at Reduced Prices 2Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 2Health News:CBS’ Criminal Minds takes aim at skin disease with Morgellons in the Mix 3
... International AIDS Society (IAS), conveners of the International AIDS ... People Living with HIV (GNP+), the International Council of ... with HIV/AIDS (ICW) and the United Nations Joint Programme ... civil society and local partners for the XIX International ...
... the effectiveness of a broad selection of popular slimming ... found no evidence that any of them facilitate weight ... today (Monday) at the International Congress on Obesity in ... than the fake supplements they were compared with. ...
... of nearly 150 randomized controlled trials on children all ... 60 percent of the studies either failed to take steps ... describe those measures. A report of the team,s findings ... experimental trials sponsored by pharmaceutical or medical-device makers, along with ...
... HealthDay Reporter , FRIDAY, July 9 (HealthDay News) -- ... the United States in recent years, are exposing patients to ... of its kind. , , But experts really don,t know ... long-term effects will be, according to new research published online ...
... 9, 2010) -- At the 52nd meeting of the ... from July 18 - 22, 2010 in Philadelphia, PA, ... to share the latest developments in medical imaging and ... discuss many of the ethical and regulatory issues that ...
... , FRIDAY, July 9 (HealthDay News) -- Researchers report ... addiction in rats and may have the same effect in ... of the journal Nature , are preliminary, but they ... of anti-addiction medications," said study senior author Paul J. Kenny, ...
Cached Medicine News:Health News:Civil society and local partners for XIX International AIDS Conference (AIDS 2012) announced 2Health News:Civil society and local partners for XIX International AIDS Conference (AIDS 2012) announced 3Health News:New research finds no evidence that popular slimming supplements facilitate weight loss 2Health News:New research finds no evidence that popular slimming supplements facilitate weight loss 3Health News:Pediatric clinical studies appear prone to bias, Hopkins review shows 2Health News:Pediatric clinical studies appear prone to bias, Hopkins review shows 3Health News:Cumulative Radiation Doses Seen in Cardiac Imaging 2Health News:Cumulative Radiation Doses Seen in Cardiac Imaging 3Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 2Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 3Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 4Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 5Health News:Preliminary highlights of the AAPM 52nd Annual Meeting, Philadelphia, Pa., July 18-22, 2010 6Health News:Rat Study Sheds Light on Cocaine Addiction 2
TG (Ab) RIA Thyroid Function 014-HD 27.1 Thyroglobulin...
Free T4 EIA Thyroid Function 025-BC-1008...
... immunoassay (EIA) test kit is to be ... estriol in human serum during the second ... is an enzyme immunoassay, which is based ... procedure, estriol is conjugated to the enzyme,horseradish ...
... The procedure follows the basic principle of ... competition between an unlabeled antigen and an ... sites of a specific antiserum . The ... estrone) bound to the antibody is inversely ...
Medicine Products: