Navigation Links
Pharmacyclics Announces Data Presentations for Ibrutinib in B-Cell Malignancies
Date:12/10/2013

ts' first treatment at OSU (OSU Tx1), 16% (n=27), 33% (n=58), and 51% (n=89) of pts received an ibrutinib-based therapy, cyclin-dependent kinase inhibitor-based therapy (CDKi), or other therapies (O), respectively.

The ORR was significantly different among groups at 56%, 45%, and 24% in the ibrutinib, CDKi, and O groups, respectively. 12-month progression free survival (PFS) estimates were 77%, 38%, and 17% in the ibrutinib, CDKi, and O groups, respectively. 12-month overall survival (OS) estimates were 81%, 78%, and 58%. Notably, age did not correlate with response, PFS, or OS.

-ORAL PRESENTATION- CLL Abstract #673:
Single Agent Ibrutinib Achieves Equal Responses in CLL Patients With and Without Deletion 17p
Mohammed Farooqui, DO, National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, MD

This phase 2, single center, study of ibrutinib as a single-agent aimed to address the role of ibrutinib in the treatment of CLL patients with del 17p, regardless of their prior treatment history. The study enrolled 29 patients with del 17p, and 24 elderly patients without del 17p (NL 17p). Fifteen of the del 17p patients and eight of the NL 17p patients were treatment naive. The primary endpoint of the study was response after 6 months, assessed by computed tomography (CT) scans, bone marrow biopsies, and routine clinical and laboratory studies.

At six months, 47 patients were evaluable. Of the patients with del 17p, 53% achieved a PR and 43% achieved a PRL, compared to 82% PR and 9% PRL among the NL 17p patients. The apparent difference in response rates is due to slower clearance of the treatment-induced lymphocytosis in the del 17p patients; however, the clinical benefit and disease control in all tissue sites was equal for both cohorts of patients. Twenty-month PFS was 100% in the NL 17p cohort, and 85% in the del 17p cohort.

The
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related medicine technology :

1. WuXi PharmaTech to Partner with Pharmacyclics
2. Pharmacyclics Reports Third Quarter 2013 Results
3. Pharmacyclics Announces Date of Conference call to discuss Financial Results for Third Quarter Ended September 30, 2013
4. Pharmacyclics Reports Second Quarter 2013 Results
5. Pharmacyclics Announces Date of Financial Results for Second Quarter Ended June 30, 2013 and Conference Call
6. Pharmacyclics Reports First Quarter 2013 Results
7. Pharmacyclics Announces Date of Financial Results for Three Months Ended March 31, 2013 and Conference Call
8. Pharmacyclics Triggers Fourth Milestone Payment for Enrollment of 5th Patient in Frontline Phase III CLL Study
9. Pharmacyclics Announces Third Breakthrough Therapy Designation for Ibrutinib from the U.S. Food and Drug Administration
10. Pharmacyclics, Inc. Prices Public Offering of Common Stock
11. Pharmacyclics, Inc. Announces Proposed Public Offering of Common Stock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... July 25, 2014 /PRNewswire-iReach/ -- "Australia Capsule Endoscopy Systems ... the Australia Capsule Endoscopy Systems market. The report provides ... and average prices (in US dollars) within market segments: ... , Capsule Endoscopes , Capsule Endoscopy Data ... The report also provides company shares and distribution shares ...
(Date:7/25/2014)... July 25, 2014  Smile Train and its technology ... their Virtual Surgery Simulator among leading global health innovations ... place in Washington, D.C. at ... "Smile Train is honored to be ... community of innovators in health and medicine that TEDMED ...
(Date:7/25/2014)... /PRNewswire-iReach/ -- Full Service CRO WCCT Global ... President of Business Development. Peter has been in the ... of different business development positions with some of the ... related to business development/sales management and marketing.  The experience ... him a key and strategic asset to WCCT Global ...
Breaking Medicine Technology:Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 2Smile Train and BioDigital Selected to Showcase Virtual Surgery Simulator in The Hive at TEDMED 2014 3Contract Research Organization WCCT Global Welcomes Peter Nieto as Vice President of Business Development 2
... LAS VEGAS, Oct. 26 Cord Blood America, Inc ... ), the umbilical cord blood stem cell preservation company ... cells to families nationwide and internationally, today announced its Chairman, ... Company,s stem cell collection business in China in an interview ...
... sectors -- HONG KONG, Oct. 26 /PRNewswire-Asia/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
Cached Medicine Technology:Cord Blood America Updates Its Stem Cell Collection Business in China 2Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 2Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 3Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 4Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 5Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 6Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 7Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 8Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 9
(Date:7/25/2014)... As reported by Wood TV 8 in the article ... seen a nearly 500-person increase in heroin related overdose deaths ... between 1999 and 2002, the toll increased to 728 during ... states, drug users in Michigan have turned to heroin after ... the price of both substances, noting that an 80-milligram pill ...
(Date:7/25/2014)... 2014 (HealthDay News) -- The human brain can preserve ... a new study finds. Although dehydration significantly ... have found that the brain compensates by increasing the ... "This research has helped us understand a lot more ... in extreme conditions," study first author Steven Trangmar, a ...
(Date:7/25/2014)... 25, 2014 Ticket Down is ... Milan tickets in Berkeley at California Memorial Stadium. With ... fans of football, the organizers of the 2014 Guinness International ... teams to North America. With teams representing La Liga, English ... bring some of the best football players from around the ...
(Date:7/25/2014)... This is a professional and ... Galactooligosaccharides (GOS) industry in Global and China. ... industry, including definitions, applications and industry chain structure. ... are provided with a focus on history, developments, ... comparison between the international and Chinese situation is ...
(Date:7/25/2014)... July 25, 2014 (HealthDay News) -- Babies seem to ... By the time women are 34 weeks pregnant, ... their mother,s voice reciting a familiar nursery rhyme, the ... source of sensory stimulation in the developing fetus," Charlene ... of Florida,s College of Nursing, said in a university ...
Breaking Medicine News(10 mins):Health News:Rise in Heroin Use, Overdose Deaths in Michigan 2Health News:Human Brain Has Coping Mechanism for Dehydration 2Health News:Real Madrid vs. Inter Milan Tickets Berkeley: Ticket Down Slashes Ticket Prices on Guinness International Champions Cup Tickets at California Memorial Stadium 2Health News:Real Madrid vs. Inter Milan Tickets Berkeley: Ticket Down Slashes Ticket Prices on Guinness International Champions Cup Tickets at California Memorial Stadium 3Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 2Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 3Health News:Rhymes Reveal Evidence of Learning in the Womb 2
... such as not using condoms or having sex with ... sexually transmitted diseases, but perhaps not as much as ... researchers say. , The findings, which UF and University ... Sexually Transmitted Diseases , could help health-care providers ...
... 3 eDiets.com, Inc. (Nasdaq: DIET ... healthy lifestyle solutions, today announced that it received a notice ... of the Company,s listed securities has fallen below $35 million, ... Market, in compliance with NASDAQ Marketplace Rule 4310(c)(3)(B). The ...
... less apt to include adult smokers, study finds, , , FRIDAY, ... more secondhand smoke than their wealthier counterparts, a new study ... "poor kids are far more likely to live with multiple ... Michael Weitzman, a professor of pediatrics at New York University. ...
... awarded $15,000 for envisioning the ,home of the future, ... At the Embedded Systems Conference (ESC) Silicon Valley 2009 ... of the Microsoft Windows Embedded SPARKs Will Fly developer ... innovation among the embedded hobbyist and academic communities. The ...
... the growing number of Pennsylvanians who are trying to ... in federal cigarette taxes, the Department of Health today ... www.determinedtoquit.com ."The average smoker makes between five and ... have support are more likely to succeed," said Secretary ...
... risk from overdosing following the surgery, study found , , FRIDAY, ... to one in five deaths among people who have had ... relieve lower back pain. , Among this group, middle-aged ... risk of either accidental or suicidal analgesic poisoning compared to ...
Cached Medicine News:Health News:Partner behavior better predicts STD risks 2Health News:Partner behavior better predicts STD risks 3Health News:eDiets.com(R) Receives NASDAQ Notice Regarding Market Value of Listed Securities 2Health News:eDiets.com(R) Receives NASDAQ Notice Regarding Market Value of Listed Securities 3Health News:Poor Kids Exposed to More Secondhand Smoke 2Health News:Poor Kids Exposed to More Secondhand Smoke 3Health News:Microsoft Windows Embedded Announces Winner of SPARKs Will Fly Developer Contest 2Health News:Pennsylvania Department of Health Helps Smokers Trying to Quit in Wake of Federal Cigarette Tax Hike 2Health News:Post-Op Painkillers Tied to Deaths After Spinal Fusion 2
... have a positive and negative inoculated well, ... these slides, perform QC and sample staining ... education and training programs by testing QC ... on one slide! KWIK-QC slides contain the ...
Microbiology QC Slides come with one or two droplets of an air-dried and methanol-fixed microorganism, or a single smear containing a designated microorganism population....
... Plate Capability The Equalizer 384 includes ... and equal tip spacing, choice of two software ... addition, this model allows you to evenly space ... accessing many gels and for use with 384 ...
Each slide contains a high yield of concentrated C. parvum oocysts within the positive control well. A negative control well is also included....
Medicine Products: