Navigation Links
Pharmacopeia's First-in-Class Investigational Therapy PS433540 Achieves Statistically Significant Reductions in Blood Pressure in Hypertensive Patients
Date:5/16/2008

1) receptor blockade -- in one molecule to treat high blood pressure.

"We are very pleased with the results of this important Phase 2a trial and look forward to future studies which will further assess the potential of PS433540, perhaps even beyond blood pressure lowering," said Joseph A. Mollica, Ph.D., Chairman of the Board and Interim President and Chief Executive Officer of Pharmacopeia. "We believe PS433540's dual mechanism of action may have a positive effect on diabetic kidney disease."

Patients with diabetes are at an increased risk for many complications, including high blood pressure and diabetic kidney disease. Up to 73 percent of patients with diabetes have been or are being treated for high blood pressure,(5) and an estimated 20-30 percent of diabetic patients will progress to diabetic kidney disease,(6) a devastating disease that may require patients to undergo dialysis or a kidney transplant.(7)

Pharmacopeia recently initiated a 12-week, Phase 2b clinical trial with PS433540 to evaluate the compound's safety and efficacy at three different doses versus placebo in 375 subjects with Stage I and Stage II hypertension. The study will also compare blood pressure reductions for each dose with irbesartan. Pharmacopeia anticipates completion of the Phase 2b trial at the end of 2008.

About the Phase 2a study

In this prospective study, 234 men and women with Stage I and Stage II hypertension entered into a single blind placebo run-in period for 3-4 weeks, after which 114 were randomized to receive double blind study medication for four weeks. At the time of the database lock, 108 subjects were available for evaluation, 93 of whom had both baseline and follow-up ambulatory blood pressure measurements (placebo: 25; PS433540 200mg: 35; PS433540 500mg: 33). The primary endpoint was the subjects' change from baseline in mean 24-hour systolic ambulatory blood pressure after 4 weeks of treatment. Additionally, investigators evaluated
'/>"/>

SOURCE Pharmacopeia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Pharmacopeia Announces Upcoming Late-Breaker Presentation of Phase 2a Results for Its First-in-Class Investigational DARA Compound, PS433540
2. NuRx Pharmaceuticals Doses First Patient in Phase I Clinical Trial of First-in-Class RXR Agonist NRX4204
3. Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus
4. NicOx Announces Initiation of First Phase 1 Study of Investigational Nitric Oxide-Donating Agent in Hypertensive Patients by Merck & Co., Inc.
5. Shires Investigational Nonstimulant ADHD Treatment INTUNIV(TM) (Guanfacine Extended Release) Demonstrated Significant Efficacy in Reducing ADHD Symptoms at All Measured Time Points Up to 24 Hours Postdose
6. Abbotts Phase III Studies of Investigational TriLipix(TM) (ABT-335), in Combination With Statins, Meets Primary Endpoints on Improving LDL, Triglycerides and HDL
7. Study Results Show Investigational Drug, Prasugrel, Cuts Risk of Stent-Related Clots by More than Half Versus Clopidogrel
8. FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008
9. Medarex Announces Allowance of Investigational New Drug Applications for Wholly Owned Fully Human Anti-CD19 Antibody, MDX-1342
10. AstraZeneca Completes Enrollment in First Phase III Study of the Investigational Drug Vandetanib (ZACTIMA)(R) in Non-Small Cell Lung Cancer
11. Lexicon Files Investigational New Drug Application for LX2931 as a Potential Treatment for Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/12/2014)... Sept. 12, 2014  Royal Philips (NYSE: ... innovations at ASTRO,s 56th Annual Meeting in ... increase workflow automation, confidence, consistency and accuracy in cancer ... patient-centric care, these radiation oncology solutions underscore Philips, dedication ... personalized approach to medicine. "Philips is leveraging ...
(Date:9/12/2014)...  WellStar Paulding Hospital is the first hospital in ... in the U.S. to offer a new, innovative procedure ... System, Paulding Hospital is on the cutting edge of ... Inspire Therapy offers relief for moderate to ... to use traditional treatments, like Continuous Positive Airway Pressure ...
(Date:9/12/2014)... DALLAS , September 12, 2014 ... Market by Products (Glucose Monitoring & Infectious Diseases Testing ... & Professional Monitoring), Over the Counter & Prescription Based ... studies the global POC Diagnostics Market over the forecast ... to grow at a CAGR of 9.3% from 2013 ...
Breaking Medicine Technology:Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 2Philips Demonstrates Commitment to Radiation Oncology Solutions at ASTRO 2014 3WellStar Pioneers New Sleep Apnea Treatment 2Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 2Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 3Point-Of-Care Diagnostic Market Worth $27.5 Billion by 2018 4
... Thousands of jobs in Texas supported by the ... – such as imposing new taxes in the Medicare ... From research to technical work, manufacturing to ... care services, the biopharmaceutical sector supports a broad array ...
... REDWOOD CITY, Calif. and SAO PAULO, Sept. 27, 2011 ... Raizen Energia S.A. today announced the signing of a ... ethanol process with enhanced performance economics. Raizen is Brazil,s ... the terms of the agreement, Raizen and Codexis will ...
Cached Medicine Technology:Research Demonstrates Possible Texas Job Losses from Sectors Supported by Biopharmaceutical Companies 2Research Demonstrates Possible Texas Job Losses from Sectors Supported by Biopharmaceutical Companies 3Codexis, Raizen to Develop First Generation Ethanol 2Codexis, Raizen to Develop First Generation Ethanol 3
(Date:9/15/2014)... DC (PRWEB) September 15, 2014 ... payment initiatives that bring providers on board as ... member satisfaction. When bundled payment programs are designed ... financial incentives, incentivize hospitals to work collaboratively with ... procedure-specific tally. On Sept. 24, the Atlantic Information ...
(Date:9/15/2014)... More than 30 million additional Americans ... Care Act. This fact begs the question “are there ... reform and an aging population create a demand for ... are trying to stay on top of the anticipated ... 204 days to fill, according to the Association of ...
(Date:9/15/2014)... FL (PRWEB) September 15, 2014 (PRWEB) September 15, 2014 ... what’s not; what the startup business requirements are in ... the new business. , Speakers include industry professionals, such ... Health Center in Oakland,CA and cannabis business consultant ... , who are already successfully running legal marijuana businesses ...
(Date:9/14/2014)... Petersburg, FL (PRWEB) September 15, 2014 Skin ... external factors like sun damage and not moisturizing properly. However, ... if skin has been cared for. , Two main reasons ... 2) Loss of hyaluronic acid in the skin , During ... and both of these are responsible for important moisture retention ...
(Date:9/14/2014)... (PRWEB) September 14, 2014 Government ... growth of the patient handling equipment market , ... lucrative growth potential for the next five years. ... the rise in geriatric population and increasing lifestyle ... leading to increased disabilities. Further the market is ...
Breaking Medicine News(10 mins):Health News:Sept. 24 Webinar to Profile Geisinger Health System, BCBS of North Carolina’s Successful Bundled-Payment Programs 2Health News:Affordable Care Act Poses Challenge for Hospital Recruiters, with Nationwide Physician Shortage Looming in the Near Future 2Health News:How to Start And Run a Successful Legal Marijuana Business 2Health News:2 Reasons Skin Becomes Dryer with Age and What To Do About It, From Sublime Beauty® 2Health News:2 Reasons Skin Becomes Dryer with Age and What To Do About It, From Sublime Beauty® 3Health News:10.7% CAGR For Patient Handling Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 2Health News:10.7% CAGR For Patient Handling Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 3Health News:10.7% CAGR For Patient Handling Equipment Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com 4
... , ... (Vocus) December 8, 2008 -- Losing a child to the ... , it is a tragedy they have experienced firsthand. The nonprofit organization ... the flu or have had a child experience severe medical complications from ...
... 8 - 14; Urges Immunization into December, January and Beyond ... Dec. 8 Mothers -- often the family,s primary healthcare ... families vaccinated against influenza throughout the winter months and even ... American Lung Association as part of its Faces of ...
... suggests it,s a promising candidate as marker for metastasis ... that may contribute to the spread of breast cancer ... (called Menainv) is present in invasive cells within a ... biomarker for metastatic breast cancer, the scientists said. , ...
... Technologies(R), a leading,provider of radio frequency identification systems and ... Designed to allow,hospitals easier access to the Safe Place ... financing, this option is especially helpful,in today,s tight economy. ... to offer a new way for hospitals to implement ...
... Conn., Dec. 8 SearchMedica.com,( http://www.searchmedica.com/ ), the ... new Radiology search channel. The search,channel connects radiologists ... relevant online medical imaging resources. , ... medical professional at some point,no matter what their ...
... to keep,families healthy and make it easier to get a ... largest retail health,care clinic in the U.S., announced that they ... this Fall,s flu shot season. , ... (NYSE: CVS ), launched,an integrated campaign on Oct. ...
Cached Medicine News:Health News:For Kids, the Flu Can Be Severe, Even Deadly 2Health News:For Kids, the Flu Can Be Severe, Even Deadly 3Health News:Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring 2Health News:Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring 3Health News:Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring 4Health News:Survey Shows Mothers See Value in Influenza Vaccination for Their Families Through the Winter and Spring 5Health News:Scientists ID Protein Aiding Breast Cancer Spread 2Health News:RF Technologies(R) Introduces Safe Place(R) Usage Program Financing for Its Infant Security, Pediatric Security and ED Safety Solutions 2Health News:RF Technologies(R) Introduces Safe Place(R) Usage Program Financing for Its Infant Security, Pediatric Security and ED Safety Solutions 3Health News:SearchMedica Launches Radiology Search Channel for Medical Professionals 2Health News:CVS/pharmacy and MinuteClinic Reach Goal of Delivering One Million Flu Vaccinations 2Health News:CVS/pharmacy and MinuteClinic Reach Goal of Delivering One Million Flu Vaccinations 3
The GII titanium anchor is the "Gold Standard" for soft tissue reattachment to bone. The GII's small size, high pull-out strength and wide range of clinical applications make it the anchor of choice ...
... Revo Suture Anchor offers a simple and ... rotator cuff repair. The cutting tip requires ... with two #2 strands of braided polyester ... are avoided with the Independent Suture Sliding ...
The Atakr II RF Generator provides high power output with the integral safety of closed-loop temperature control using the embedded thermocouples in Medtronic RF ablation catheters....
... The only truly dedicated electrophysiology system ... EPX2 Bi-Plane System incorporates Fischer's patented "C ... and patient support personnel the ultimate in ... approach, the ceiling suspended EPX2 minimizes equipment ...
Medicine Products: