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PharmacoFore, Inc. Announces Positive Results from a Phase I Clinical Study of Its Hydromorphone Bio-Activated Molecular Delivery™ System, and Upcoming Presentation at the 2011 BIO Business Forum During the Annual BIO International Convention in Was
Date:6/23/2011

SAN CARLOS, Calif., June 23, 2011 /PRNewswire/ -- PharmacoFore, Inc., a privately held biopharmaceutical company developing next-generation abuse-resistant prescription drugs, today announced positive results from a Phase I human proof-of-concept (hPOC) study of its hydromorphone (HM) Bio-Activated Molecular Delivery™ (Bio-MD™) product candidate, PF329.  Greg Sturmer, VP, Finance and CFO, will present at the 2011 BIO Business Forum during the annual BIO International Convention at the Walter E. Washington Convention Center in Washington, D.C.  Mr. Sturmer's presentation will be given on Thursday, June 30, 2011, at 10:00 a.m. EDT in the Georgetown Room.  The presentation will include an overview of the company's Bio-MD™ and Multi-Pill Abuse-Resistance™ (MPAR™) technologies and pipeline.

The Bio-MD™ technology is designed to release clinically effective opioid drug only when exposed to the correct physiologic conditions (i.e., when orally ingested). The result is activation and controlled release of an opioid drug in the gastrointestinal tract, which is then absorbed normally into the patient's blood stream.  This approach achieves two important goals: (i) greatly reducing the opportunities for abuse of opioid drugs, and (ii) maintaining, unaltered, the opioid's potent analgesic effects in a safe manner.

The Phase 1 hPOC study demonstrated that PF329 is safe and releases HM in a dose-proportional manner and that the process of delivery is efficient.  Time to maximal plasma concentration of HM following administration of PF329 is approximately two hours, slower than immediate release HM and more rapid than the published data for the commercial, once-per-day HM product, Exalgo®.  By delivering PF329 in solution in this study, PharmacoFore demonstrated that the extended release profile is intrinsic to the molecule; that is, the Bio-MD technology does not involve the reformulati
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SOURCE PharmacoFore, Inc.
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